1) Apparently snails can eat graffiti

2) Apparently snails actively seek out graffiti to eat

3) ???

4) Start a biotech company that sells snails for graffiti removal

Very proud of this work and all the efforts from my team and collaborators on this! You can now use DGRs for in vivo targeted hypermutagenesis in E. coli. We also included some early proof of concept in Yeast thanks to @seth-shipman.bsky.social !

What if you could tap into a continuous stream of biological data? Why we should build an automated biology CORE that never sleeps

Is there a “Plasmidsaurus for experimental data?” What is the fastest, cheapest way to start offering services that scientists want?

To answer these questions, we have to build the CORE
americanwetware.substack.com/p/build-the-...

In today’s post, I describe an engineering challenge that could bring scalable, on-demand services to other biotech operations.

Biology services that are less versatile, but still scalable and on-demand, have proven value. DNA synthesis, strain banking and plasmid sequencing providers have accelerated science and found many happy customers.

“Cloud labs” focus on versatility. A cloud compute server can do anything a computer can do. An analogous biology service would need to execute all possible biology lab protocols - a profoundly ambitious vision.

Cloud computing is a good product: versatile, scalable, on-demand.

Biotech service providers have tried to reproduce this formula. But what if we’ve been focusing on the wrong features?

I will personally award the Nobel Prize in Chemistry to the first person who engineers a peptide that can do the worm

Hands-free lab automation solves this problem

We know that AI increases the value of human biological data. But by how much?

Super interesting to see a specific class of human biological data assigned a spot price in a real market event

Lab coats should have elastic scrunchies on the sleeves

16 years ago I blew off my thesis research for one day to make a YouTube video about plasmids
www.youtube.com/watch?v=pNeC...

Today I'm in the plasmid sequencing tutorials for Plasmidsaurus
www.youtube.com/watch?v=pNeC...

The trick to having a fun career in science is say yes to random fun things

I spent the last week vibe coding immunotherapies for dogs YouTube video by American Wetware

@synbio1.bsky.social is cooking again youtu.be/nHJKpC2GUsw?...

Me when I click on an in-line citation in an online article and it takes me to the references section of the same article instead of opening the new article in a new tab

Bioproduct idea: sooner oats

We’re so blessed that evolution made the shape of eggs be the literal only possible shape for eggs that isn’t deeply unsettling

Biotech startups 0.0003 nanoseconds after the lab team ships a breakthrough drug to clinical trials

The funniest version of the future is the one where we invent ASI only to watch it immediately start culturing brain cells to invent ASSI

www.cell.com/cell-reports...

Have fun in the small pumpkin underclass losers

Me and everyone who keeps calling it Pichia pastoris holding out against the attempt to rename it Komagataella phaffii

How it feels to start opening tabs on a new research project

There are still some good gene splicer jobs

You must assemble the 4 lost parafilms of type "L," "N," "O" and "P"

The children yearn for bioproducts

fruitpilled peachcel

I'll give you the secret tech for good popcorn: nutritional yeast

The good version of the future includes a decentralized bioeconomy supporting lots of good green-collar jobs in bioproducts and bioservices

Sourdough microbakeries hint at what that future might look like
www.nytimes.com/2026/01/26/d...

If you had an LLM from the year 3000 and a writer's room of all the greatest communicators in history you could never invent a more worthless and confusing name for a statistical technique than "Design of Experiments"

The fancy popcorn from the organic market is bad at popping compared to the cheap popcorn from the normal grocery store and I’m tired of pretending it’s not