Synthetic Immunological Niche Reveals Early Immune Dysregulationand Stratifies Therapeutic Response in Type 1 Diabetes www.biorxiv.org/content/10.64898/2026.03...

Longitudinal monitoring of type 1 diabetes progression to disease onset Subcutaneous monitoring for type 1 diabetes identifies disease progressors from an at-risk group before symptom onset.

Excited to share this new work from Shea lab which combines biomaterials platform with transcriptomics machine learning analysis to monitor autoimmune Type 1 Diabetes: www.science.org/doi/10.1126/...

Longitudinal monitoring of type 1 diabetes progression to disease onset Subcutaneous monitoring for type 1 diabetes identifies disease progressors from an at-risk group before symptom onset.

Novel methods for non-invasive interrogation of the onset of type 1 #diabetes #T1D www.science.org/doi/10.1126/...

Dynamic Immune Cell Composition, Phenotypes, and Signaling in an Engineered Metastatic Niche In breast cancer patients, metastasis is the stage of disease where prognosis significantly worsens. However, the timing at which metastasis initiates and the location of metastatic lesions in an org...

Excited to contribute as a co-first to this new article from the Shea Lab. Using a minimally invasive synthetic metastatic niche, we show how immune cells shift from tumor-fighting to tumor-supporting over time, revealing metastatic dormancy vs growth in breast cancer.
doi.org/10.1002/bit....

🔥Smoking hot new paper and tweetorial from @djcalebc.bsky.social (collab with Chinnaiyan Lab)! 🔥

We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼

#T1D -related TCR motif enrichment based on genetic risk, offering a potential metric for autoreactivity and basis for TCR-based diagnostics and therapeutics. www.medrxiv.org/content/10.1...