Beautiful study of conserved gene essentialness by Brenda Andrews - the yeast cell map thecellmap.org @lornegenome.bsky.social

Brenda Andrews: yeast 🥪 a fantastic systemic genetics, all viable deletion mutants are available. Using to map genetic interactions ➡️ link phenotype to genotype

Title was the preprint, but talk an absolute tour de force of ocular genetics. Alex asks - are we ready for genetic risk scores informing early intervention for glaucoma.

Alex Hewitt @utas.edu.au speaking about spatial transcriptome analysis of glaucoma @lornegenome.bsky.social @biorxivpreprint.bsky.social doi.org/10.1101/2025...

Link to Odom lab (not the talk series linked above) www.dkfz.de/en/regulator...

A complex story - deeper computational dive from Martin Taylor's team Strand resolved mutagenesis of DNA damage and repair. doi.org/10.1038/s415... @lornegenome.bsky.social

Choose your own adventure @lornegenome.bsky.social Duncan Odom www.lifepi-hd.com/duncan-odom asks if we want greatest hits or new hot stuff - role on hot stuff!

Congratulations Hannah Coughlin @wehi-research.bsky.social winner of the 2026 Millennium Science @lornegenome.bsky.social mid career prize, for her work on the 3D-genome.

SemanticST: Spatially Informed Semantic Graph Learning for Clustering, Integration, and Scalable Analysis of Spatial Transcriptomics Spatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogeneity. However, current...

Hamid speaking to new tool: SemanticST to analyse spatial transcriptomics and preprinted @arxiv.bsky.social arxiv.org/abs/2506.11491

Hamid Alinejad-Rokny heads the UNSW biomedical machine learning laboratory and is applying generative AI to spatial transcriptomics www.unsw.edu.au/staff/hamid-... #LorneGenome

The @lornegenome.bsky.social 2026 Millennium Science award to mid career researchers to acknowledge outstanding contributions to Australian genomic research, including novel analytical concepts. #LorneGenome Congratulations Hamid Alinejad-Rokny (UNSW) and Hannah Coughlan (WEHI)

Lorne Genome 2026 @lornegenome.bsky.social kicking off with the e-for-evil/e-for-effector pathogen ORF screen @miketilapia.bsky.social - preprint @biorxiv-immuno.bsky.social doi.org/10.1101/2025...

@asscr.bsky.social #ASSCR2025 conference has been great - terrific science, networking and location. Join us for #ASSCR2026 in Melbourne, 9-11 November, 2026. See you there!

ChatGTP empowered Chemical screening platform www.chemperturbdb.com

The final keynote of #ASSCR2025 from @shuibingchen.bsky.social on building pancreatic islet with beta cells, blood vessels and macrophages. doi.org/10.1016/j.st...

A village in a dish model system for population-scale hiPSC studies The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions. Human induced pluripotent stem cells are uniquely suited to ...

Drew Neavin #ASSCR2025 using 'village in a dish' models to study the genetics underpinning cardiotoxicity Unpublisjed data so reference is to the village in a dish model. pmc.ncbi.nlm.nih.gov/articles/PMC...

Ralph Patrick is looking for dosage-sensitive transcription factors that may impact ageing #ASSCR2025 doi.org/10.1016/j.cm...

Luke and collaborators takes it further by exploring TF/chromatin structures to identify cofactors of P53 #ASSCR2025 doi.org/10.1016/j.mo...

Mechanisms of OCT4-SOX2 motif readout on nucleosomes Site-specific nucleosome engagement by pluripotency factors reveals how transcription factors distort nucleosomes at chromatinized motifs.

Try doi.org/10.1126/scie... Luke Isbel #ASSCR2025

Luke Isbel exploring chromatin codes in pluripotency #ASSCR2025 doi: 10.1126/science.abb0074

Refate identifies chemical compounds to target trans-regulatory networks for cellular conversion Identifying chemical compounds that target trans-regulatory networks (TRNs) underlying molecular programs of cells for directed cellular conversion (i.e. differentiation, reprogramming, transdifferent...

Kathrine Zyner presents 'ReFate' #ASSCR2025 which combines gene regulatory networks with compounds that impact on these regulatory pathways to improve cell reprogramming @biorxivpreprint.bsky.social doi.org/10.1101/2025...

Automated Integration of Multi-Slice Spatial Transcriptomics Data in 2D and 3D The field of spatial transcriptomics is rapidly evolving, with increasing sample complexity, resolution, and tissue size. Yet the field lacks comprehensive solutions for automated integration and anal...

Preprint @biorxivpreprint.bsky.social doi: doi.org/10.1101/2023... #ASSCR2025

Meet the winners of our 2025 Metcalf Prizes for Stem Cell Research: stemcellfoundation.net.au/2025_metcalf...
🧠 Dr Maria Di Biase @unimelb.bsky.social
🧠 Dr Lachlan Harris @qimrb.bsky.social
They're already making headlines ahead of the award ceremony on the Gold Coast today. @asscr.bsky.social

Hear from our 2025 #MetcalfPrizes winners – Dr Maria Di Biase and Dr Lachlan Harris – on ABC Radio Gold Coast Drive with Bern Young. Listen from 43.51 on yesterday’s show: www.abc.net.au/listen/progr...
@qimrb.bsky.social @unimelb.bsky.social @asscr.bsky.social

Day 3 #ASSCR2025 opens with Fernando Rossello benchmarking PSC-derived organoids using spatial profiling platforms. Lovely to see careful QC associated with this study.

How would you like to apply your passion for #bioinformatics to a real-world research problem?

We co-supervise PhD students in a wide variety of research groups across the University of Melbourne and the Melbourne Biomedical precinct.

If you're interested in doing a PhD with us, get in touch!

Inspiring #ASSCR2025 talk from Siok Tey @qimrb.bsky.social about home-grown clinical trials and manufacturing processes for new CART therapies.

Great first day of stem cell science on the beach at #ASSCR2025! Here is our @asscr.bsky.social president opening the conference. Highlights include keynote from @josh-brickman.bsky.social and presentation of @ausstemcell.bsky.social 2025 Metcalf awards. Congratulations to the worthy recipients!

Stem cell selfie #ASSCR2025 #miltenyibiotec @miltenyibiotec.bsky.social

Meet our Early Career Editor at #ASSCR2025! Pengyi Yang is attending the Australasian Society for Stem Cell Research (ASSCR) Conference in Gold Coast, Australia, 10-12 November 2025. Connect with Dr. Yang to discuss whether your research is a fit for publishing in Stem Cell Reports!