Muscle mass is a stronger predictor of survival than BMI in older adults

Read here: www.sciencedirect.com/science/arti...

Prevention is delayed treatment of aging

The goal isn’t longer life.
It’s longer function and performance. Longer life is the side effect

The earlier you intervene, the bigger the payoff

Steps per Day and All-Cause Mortality in Middle-aged Adults This cohort study assesses the association of step volume and intensity with premature all-cause mortality among Black and White participants in the Coronary Artery Risk Development in Young Adults…

About 7,000 steps/day is associated with ~50–70% lower mortality vs low activity
jamanetwork.com/journals/jam...

Fixed it

The future of medicine is treating causes, not symptoms. Aging is the main cause of disease

Longevity isn’t about perfection.
It’s about direction

You don’t need more time.
You need better biology

Aging is the biggest unmet medical need by orders of magnitude

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression The EMF-inducible gene switch (Ei) platform provides precise spatiotemporal control of gene expression through Cyb5b-mediated calcium oscillations. This system enables Ei-OSK-driven in vivo rejuvenati...

REMOTE CONTROL MICE! A group from Seoul has just published in Cell that they’ve discovered a crazy-weird protein (Cyb5b) that can be used to turn on any gene when exposed to EMFs. They used it to turn on OSK and extend the lifespan of a progeroid mouse. Amazing! www.cell.com/cell/abstrac...

Are annoying age spots due to epigenetic drift, a likely cause of aging?

"Consistent with the Information Theory of Aging, we found a global disruption of tight epigenetic regulation"...at genes involved in DNA repair, inflammation & mitochondria

Fascinating!

link.springer.com/article/10.1...

Low-Value Preoperative Care for Patients Undergoing Cataract Surgery at a Safety-Net Health System This study assesses the utilization and costs of a multipronged quality improvement initiative to reduce low-value preoperative utilization for patients undergoing cataract surgery at 2 safety-net…

Cardiorespiratory fitness is a strong and consistent predictor of mortality across populations jamanetwork.com/journals/jam...

We don’t lack tools.
We lack urgency

Longevity science is accelerating faster than expected

We are closer to controlling aging than most people realize

Small interventions shift long-term trajectories

If we can slow aging, we delay multiple diseases at once

Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality - Nature Medicine Using data from wearable activity monitors, this study shows that short bursts of physical activity that are done as part of daily life activities and that are only 1 or 2 minutes in length are…

Cardiovascular mortality is ~32–34% lower with brief daily bursts www.nature.com/articles/s41...

Large meta-analysis of ultra-processed food intake is linked to multiple chronic diseases, not just obesity
www.bmj.com/content/384/...

Biology is programmable

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes | NEJM Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to reduce the risk of adverse cardiovascular events in patients with diabetes. Whether semaglutide can reduce cardiovascular ...

Semaglutide reduces major cardiovascular events in people with obesity without diabetes (SELECT trial)
www.nejm.org/doi/full/10....

Most people wait for disease.
By then, biology has already shifted

Sleep Drives Metabolite Clearance from the Adult Brain During sleep, metabolic waste products are removed from the extracellular spaces in the brain. [Also see Perspective by Herculano-Houzel]

Deep sleep enhances glymphatic clearance of brain waste, including amyloid 😴 🧠 www.science.org/doi/10.1126/...

The question is no longer if we can intervene in aging.
It’s how safely and how many times

Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality - Nature Medicine Using data from wearable activity monitors, this study shows that short bursts of physical activity that are done as part of daily life activities and that are only 1 or 2 minutes in length are…

~4.4 min/day of vigorous “incidental” activity is linked to ~26–30% lower all-cause mortality
www.nature.com/articles/s41...

We don’t die from age.
We die from aging. And the letter is malleable

Age is not fixed.
It’s dynamic. This is one of the most remarkable discoveries of the century

Most people treat aging as fate.
Biology treats it as a process that can be changed

Medicine is shifting from reactive to predictive