Vincristine Treatment Protects Against Podocyte Damage in Focal Segmental Glomerulosclerosis Focal segmental glomerulosclerosis (FSGS) is associated with podocyte damage resulting in cytoskeletal alterations leading to foot process effacement. Vincristine is a chemoprotective drug which alter...

👥 Will Mason, David Long, @stefanodasacco.bsky.social, @real-drpepper.bsky.social, et al.

🏥 @uclchildhealth.bsky.social, @uclmedsci.bsky.social, @keck.usc.edu

💰 @wellcometrust.bsky.social, @kidneyresearchuk.org, @nihr.bsky.social

📕 @kireports.bsky.social:
www.kireports.org/article/S246...

Lupus Nephritis Patterns and Response to Type I Interferon in Patients With DNASE1L3 Variants: Report of Three Cases

bit.ly/3ApVOUZ

Thrilled to see UKKA here!
#Nephsky

The last slide of the presentation I gave to Twitter in my proposal for how to build Bluesky.

2. Here's an image from a presentation I gave to Twitter, representing the Twitter bird freed from a closed platform to fly in Bluesky's open ecosystem.

@kidneydoc101.bsky.social so pleased to see my lupus mentor and all round nephrologist extraordinaire here
#NephSky

Rituximab + dapa. One of my favourite combinations!

A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs placebo in a randomized trial of >2,500 participants with obesity, absolute reduction of 10/100 treated t.co/71hKD8v7Y2

Hi!
Likely due to loss of T-cell tolerance/direct infiltration of t-cells. Often Oncology will stop the drugs when creatinine increases and give empirical steroids.
Glomerular disease also seen, but not as often (TIN>90% renal cases)
I hope some Onco-nephrologists can comment more fully!
#NephSky

Large spectrum of renal complications as well.
From tubulointerstial nephritis to rarer complications.
We had the 2nd case of Nivolumab IgG4-retroperitoneal fibrosis

UCLH announces start of CAR T cell therapy clinical trial for lupus patients : University College London Hospitals NHS Foundation Trust Three patients in the UK have received an innovative treatment for the most serious form of lupus – an autoimmune condition which can cause damage to the heart, lungs, joints, brain or kidneys.

Is it a faux pas to recycle a Tweet/X post here..?
Somethings are worth say twice!

Delighted to be involved in CAR-T trial in lupus. Better treatment v much needed in our patients with kidney disease.

CAR-T and autoimmunity- watch this space!

#NephSky
#HaemSky

www.uclh.nhs.uk/news/uclh-an...

This has to be the 1st post I like!

Thrilled to find the Nephrology community here #nephsky
Looking forward to reconnecting with my fellow nephrons and social media connoisseurs!

@toates.bsky.social
@hswapnil.bsky.social
@kidneyboy.bsky.social
@nephrosparks.bsky.social
@sstoneman.bsky.social