New paper in Genes & Dev: we dissected how Sox2 — a key pluripotency TF — is regulated by a distal enhancer cluster (SCR) 100 kb away. The results challenge simple models of cohesin-mediated loop extrusion of gene regulation. genesdev.cshlp.org/content/earl... 🧵

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

I want a "conference" where every academic cooks a dish for everyone and we all talk about our work casually while cooking. People can sous chef for each other. We eat and talk about our work in progress. You submit an abstract and a recipe.

Our linker histone H1 paper is featured on the cover of the April 10 issue of #ScienceAdvances.
www.science.org/doi/10.1126/...
A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: www.science.org/toc/sciadv/1...

You need to make AI guidelines for your lab Here's why you should, and how to start

“first drafts of Results, Discussion, and Introduction should be the trainee’s own work. AI can help with grammar…tightening prose…critiquing the logic of an argument you’ve already made. But the hard part of forming the argument needs to be yours.’ blekhman.substack.com/p/you-need-t...

Nuclear speckles of GC richness - Nature Reviews Molecular Cell Biology Nuclear speckles support the splicing of levelled exon–intron architecture transcripts, and their evolution shaped genome organization in amniotes.

The research highlight of our recent work on nuclear speckles is online. The photo choice is eggcellent. Happy Easter! 🌸🐰🥚
www.nature.com/articles/s41...

Here are a couple of examples. Lung cancer survival rates for EGFR+ mutated Lung cancer.

Copy paste into the address bar of your browser for a random generative artwork. No AI involved.

Since moving to @stowersinstitute.bsky.social, we are now 100% focused hemipteran effectors. We have many opportunities in the lab: computational, volume EM, live imaging (multiple scales), field work, cell biology, biochemistry, etc. Interested? Reach out! Will consider any career stage.

@nygenome.org is hiring Genomic AI Fellows! (fancy postdoc positions) If you're interested in working at the interface of AI and genomics in a great environment please apply at: jobs.silkroad.com/NYGenome/Car...

right now the astronauts are calling houston because the computer on the spaceship is running two instances of microsoft outlook and they can't figure out why. nasa is about to remote into the computer

I went back to capture what the astronauts said in full when the clock was stopped at T-10 minutes and they were asked if they were go for launch:

This is Victor. We are going for our families.
This is Christina. We are going for our teammates.
This is Jeremy. We are going for all humanity.

I'm thinking about doing High Content Imaging/ Analysis for my summer lunch and learn.

What is something that you wish someone had told you when you first started out?

Elsevier costs were ~£1.7B in 2025 newsletter.journalology.com/p/elsevier-2...

Compare that to arXiv 👇

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

🧵1/
Excited to share our new preprint!
We uncover a new layer of control in how cells restart transcription after mitosis.
👉 TTF2 prevents premature rRNA transcription during mitotic exit
(www.biorxiv.org/content/10.6...)

Friends in NY, I shall be giving a public lecture at NYU Abu Dhabi Institute, 19 Wash. square at 5pm April 2nd as part of a NYU/ @college-de-france.fr visiting program. With Diderot, Haeckel, Isidore G. St Hilaire, Meckel, Perec and the embryo as guest stars. Also about the Enlightments💡😕 Please RT🙏

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

AP-1 mediates cellular adaptation and memory formation @natcomms.nature.com @pennmedicine.bsky.social
@arjunraj.bsky.social @penngenetics.bsky.social
www.nature.com/articles/s41...

Spectral multiplexing is typically limited to 4-5 channels. Our new preprint introduces a framework that utilizes DNA barcoding and signal tuning to enable robust spectral unmixing and ground-truth benchmarking to achieve 15-plex subcellular profiling without cycling
www.biorxiv.org/content/10.6...

@mukherja.bsky.social work on RNAPII clusters is in print today: www.nature.com/articles/s41...
Congrats!
TLDR: RNAPII clusters represent transcriptonally engaged molecules at single genes, not super-stochiometric assemblies.
Please check it out and see the the thread below for a summary.

I’m excited to share that my PhD work is now published in @natcomms.nature.com! Big thanks to @davidsuter.bsky.social & @beatfierz.bsky.social for your guidance throughout this work. We show that electrostatic differences in disordered regions control TF search and chromatin invasion.

More details👇

How do pairs of DNA loci - such as enhancers and promoters - find each other inside the nucleus? 🤔

Most models assume the random forces driving locus motion are independent in space

New preprint by
@janniharju.bsky.social: this assumption fails in living cells 🧵

www.biorxiv.org/content/10.6...

Postdoc position:Computational Biophysics of Disordered Proteins, Lindorff-Larsen group, University of Copenhagen, Denmark https://tinyurl.com/REWIRE-PD Deadline May 3rd, 2026

We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins

We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social

tinyurl.com/REWIRE-PD

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule The druggability of intrinsically disordered regions.

Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !

Ever wondered how a eukaryotic transcription factor finds its specific DNA motif in the vast genome? In this preprint, we directly measured the dynamics of this search process in living cells, revealing a cooperative mechanism mediated by disordered regions. 1/10 doi.org/10.64898/202...

Some molecular machines, like ribosomes, can persist for long periods of time in cells.

Could molecular aging of ribosomes shape how proteins are made?

In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)

www.biorxiv.org/content/10.6...

How do the H2A.Z histone variant and its dedicated chromatin remodeller SRCAP regulate gene expression ?
Beautiful work from @armelletollenaere.bsky.social now published @ www.nature.com/articles/s41...

what US biomedical research is dealing with @mikesacks.bsky.social

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...