Advertisement · 728 × 90

Posts by James Manton

Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.

Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.

The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year.

Applications are open now!

More details: mrclmb.ac.uk/careers-and-...

Please share this post with anyone who may be interested!

5 days ago 14 16 0 2
Post image Post image

🔬 UK researchers - funding is available to access world-class bioimaging facilities!
The UK Bioimaging User Access Fund offers up to £5K for bioimaging or £2K for image analysis at 6 UK sites
Open to PhD students, postdocs, technicians & PIs
📅 Next deadline: 31 Jul '26
👉https://shorturl.at/M2ckv

1 week ago 7 2 0 0

We are very excited to present spatial-spectral single-molecule microscopy. We use spatial patterning of filters on commercial cameras to enable multiplexing and spectroscopy. We really put the technique through its paces, and it did everything we threw at it!

www.biorxiv.org/content/10.6...

1 week ago 7 1 0 0
Women scientists look at sample

Women scientists look at sample

Been away from scientific research for over a year and want to get back to the bench?

LMB's new Career Returner Fellowship bridges the gap for those who want to re-enter lab-based research.

Applications open 13 April

More info mrclmb.ac.uk/careers-and-...

PLEASE SHARE THIS!
@mrclmb.ac.uk

2 weeks ago 9 15 0 2

Sure! I’m around until Wednesday lunchtime. Will try and track you down.

3 weeks ago 0 0 0 0

To be clear, all data storage is local. I, nor no-one else, knows which talks you've selected unless you share the JSON export with them. This also means you'll need to send that file to yourself if, for example, you make you selections on a laptop but want to check them on a mobile phone.

3 weeks ago 0 0 0 0

This comes with absolutely no guarantee for accuracy, usability or utility! I've tested it a bit, but I'm sure there are some ways to break it. It's probably known by the state of California to cause cancer...

3 weeks ago 0 0 0 0
A screenshot of the FOM talk planner, showing two talks on Sunday that occur at different times, and two talks on Tuesday that clash temporally.

A screenshot of the FOM talk planner, showing two talks on Sunday that occur at different times, and two talks on Tuesday that clash temporally.

In preparation for Focus on Microscopy 2026, I cajoled an LLM to build the website below to aid in designing a personal programme of which talks to attend. It'll warn you when you select two talks that occur at the same time and works on mobile with no account.

www.mrc-lmb.cam.ac.uk/jmanton/fom2...

3 weeks ago 8 0 3 1
Advertisement

I have been unreasonably fortunate to work with some extremely clever and notably kind people during my career so far. Katerina is a prime example of such. Whilst I obviously cannot guarantee the outcome of any endeavour, I'll be damned if I don't recommend this PhD opportunity most wholeheartedly!

3 weeks ago 9 2 0 0
Microscopic view of a glowing, irregularly shaped primordial germ cell with long protrusions with purple and green fluorescence against a dark blue background.

Microscopic view of a glowing, irregularly shaped primordial germ cell with long protrusions with purple and green fluorescence against a dark blue background.

How do primordial germ cells (PGCs) migrate across a developing embryo?

#LMBResearch from Katharine Goodwin and Kate McDole (@cellbiol-mrclmb.bsky.social) uncovers the mechanisms PGCs use in mouse embryos to navigate this long and surprisingly risky journey.

Read more: mrclmb.ac.uk/news-events/...

1 month ago 17 9 0 1
Post image

Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵

www.biorxiv.org/content/10.6...

1 month ago 42 19 1 4
Video

Optical clearing & time-lapse fluorescent imaging of Live mouse Brain (up to 800 μm of depth)🤯

An acute olfactory bulb slice(P11) loaded with GCaMP6f (Ca2+ sensor) was imaged with #2PM at a depth of 150 μm during clearing with SeeDB-Live👹

#NatMethods 2026
www.nature.com/articles/s41...

1 month ago 62 15 1 1
Preview
BBC Radio 4 - In Our Time, Archaea How a discovery in the 1970s changed the theory of the origin of complex life on earth.

On today’s episode of BBC Radio 4’s In Our Time, @buzzbaum.bsky.social, Group Leader in @cellbiol-mrclmb.bsky.social, joined for a discussion on all things archaea.
Check it out here (requires BBC login): www.bbc.co.uk/programmes/m...
#LMBintheNews

1 month ago 20 6 0 1

Myself and @immunoah.bsky.social are looking to hire a postdoctoral scientist to build a next-generation high-throughput high-resolution light sheet microscope for imaging entire cleared organs/tissues and to further develop live & fixed tissue clearing methods.

www.nature.com/naturecareer...

1 month ago 20 16 0 0

www.biorxiv.org/content/10.6... Amazing work by Kris and gang! For the first time we have been able to image division ring components live in Sulfolobus. And guess what - CdvA is asymmetrically inherited.

1 month ago 48 20 1 2
Research Support Officer - Cell Biology - Dr Madeline Lancaster - LMB 2788 - Medical Research Council Location: Cambridge. Vacancy: Research Support Officer - Cell Biology - Dr Madeline Lancaster - LMB 2788. Closing Date: 25/03/2026, 23:55

📣🧠 We're looking for someone to join the Lancaster Lab family as a Research Support Officer (maternity cover).

You'll be studying the origins of human brain specialisations using brain organoids, as part of a great team at one of the world's great research environments.

mrc.tal.net/vx/mobile-0/...

1 month ago 1 2 0 0

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social

Please get in touch if you have any questions.
www.nature.com/naturecareer...

1 month ago 51 54 1 0

Fiddling around with planchettes can hurt…

3 months ago 2 0 0 0
Advertisement

Thanks, that's good to know. For our dabbles in cryo-expansion we went straight to high-pressure freezing as that's what our cryo-EM friends recommended, but plunge freezing would make the whole process a bit simpler.

3 months ago 2 0 1 0
Preview
Newton International Fellowships | Royal Society This fellowship is for non-UK scientists who are at an early stage of their research career and wish to conduct research in the UK.

The Royal Society Netwton International fellowship for non-UK early career researchers opens soon.

If anyone in the world of #upconversion is interested, please let me know because I can host.

royalsociety.org/grants/newton-international/

3 months ago 2 3 0 0

Introducing Cyclically Multiplexed Expansion Microscopy (Cy-ExM): a workflow for 3D nanoscale, high-plex imaging in whole cells. Cryo-preserved ultrastructure + iterative labeling + expansion microscopy → 20 targets in one dataset with ~70 nm lateral resolution.

www.biorxiv.org/content/10.6...

3 months ago 30 8 2 1

Interesting stuff! I'm surprised plunge freezing (rather than high pressure freezing) worked nicely for the thicker parts of the cells, particularly the one undergoing mitosis in Figure 1c. Do you think this is because issues from crystalline ice formation don't appear at this resolution?

3 months ago 1 0 1 0

Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

4 months ago 521 222 28 31

Now published with peer-review-induced improvements in Biomedical Optics Express: doi.org/10.1364/BOE.579043

We continue to recommend the use of Sarstedt lumox dishes for ease of use and high-quality imaging performance: bsky.app/profile/jame...

4 months ago 15 5 0 0
Preview
GenBio DTP Optional supporting text

I’m excited to announce that I will be starting my research group on computational enzyme design at the Generative Biology Institute, Oxford, UK (@eitoxford.bsky.social)! PhD applications are open, deadline is Jan 8th (www.chem.ox.ac.uk/genbio-dtp). Email kiarash.jamali@eit.org with any questions!

4 months ago 61 14 9 5
Preview
Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describ...

Now out in full form. Again, a big thanks to #teamtomo and @alisterburt.bsky.social for developing the infrastructure to build this on. journals.iucr.org/d/issues/202...

4 months ago 35 11 2 1

96.5 C (this is 1 mmol * the Faraday constant). Many ExM protocols call for ~20 w/v% sodium acrylate (words can barely describe my contempt for this unit presented alone!) which works out as roughly 1 mmol in the volume of a 5 mm radius sphere. It's an insane amount, but that's kind of the point...

4 months ago 2 0 0 0
Preview
Introduction to Image Analysis 2026

Applications for the next @royalmicrosoc.bsky.social “Introduction to image analysis” workshop are now open!

Join us for 3 days in Cardiff in May to learn the foundations of #bioimageanalysis using Fiji, Python and @napari.org

www.rms.org.uk/rms-event-ca...

4 months ago 14 11 1 4
Advertisement
Preview
NUKEMAP by Alex Wellerstein NUKEMAP is a website for visualizing the effects of nuclear detonations.

Given @miguelcmestre.bsky.social's recent experiments, he'd easily have annihilated most of Cambridge...

nuclearsecrecy.com/nukemap/?&kt...

4 months ago 0 0 0 0
A calculation of the energy released by four-fold swelling of a 5 mm expansion microscopy hydrogel, containing 1 mmol of sodium acrylate. The calculation assumes a sphere of uniform charge density, in water, and gives an energy of 9.4E13 Joules, or approximately 22.5 kilotons of TNT.

A calculation of the energy released by four-fold swelling of a 5 mm expansion microscopy hydrogel, containing 1 mmol of sodium acrylate. The calculation assumes a sphere of uniform charge density, in water, and gives an energy of 9.4E13 Joules, or approximately 22.5 kilotons of TNT.

For an internal talk, I wanted an easy way to disprove the prevailing myth that expansion microscopy gels expand due to repulsion between charged polymer strands. I did a quick calculation of the supposed energy released during a standard experiment and it's equivalent to a small nuclear bomb...

4 months ago 14 2 5 0