Woah 🤯

Immunofluorescence for sensory neurons (soma and axons; green), nociceptors (red), and nuclei (blue) in the human dorsal root ganglion!
Image credit: Adriana Nwasinachi Ezeji
#Painneuroscience #Painresearch #Neuroscience #Scicomm

Snapshots in Neuroscience: Mossy fiber boutons blog.eneuro.org/2024/11/snap...

Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model of the disease.

CGRP/RAMP1-mediated communication between TRPV1+ nociceptors and macrophages contributes to the growth of endometriosis lesions and associated pain, highlighting a potential treatment by inhibiting this pathway #Painresearch www.science.org/doi/10.1126/...

For this #FluorescenceFriday I thought I'd repost my favorite blog post this year: MagLOV - magnetic control of a fluorescent protein! And now @mariaingaramo.bsky.social and @andrewgyork.bsky.social are here! Give them a follow and find out what cool things are next.
blog.addgene.org/magnetic-con...

Bringing a precision medicine approach to pain management While pain is a universal human experience, the mechanisms that produce the sensation of pain in males and females vary in ways that could lead to the development of sex-specific treatments for chroni...

Proud to have contributed to this work. I’m also very excited to help lead our new Evident Discovery Center. Exciting things to come. healthsciences.arizona.edu/news/stories...

“A new study from the Max Planck Institute for Molecular Biomedicine has revealed that the bone marrow in the skull behaves uniquely compared to other bone marrow compartments, showing an unexpected resilience to aging.” Summary here: analyticalscience.wiley.com/content/news...

Dorsal view of a 5 days post fertilization zebrafish larva that has been stained with an unknown antibody. Image taken with confocal microscope.

Confocal image of a five-day-old larval zebrafish head. Credit to Dr. Hideo Otsuna at University of Utah. #ZebrafishZunday 🧪

“Bad antibodies result in a waste of time and resources that some say has contributed to a ‘reproducibility crisis’ in the biological sciences, potentially slowing the pace of discovery and drug development” www.nature.com/articles/d41...