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Posts by Alex Williams

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🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social

We gave a worm brain control of a fly body and it walked

What did we learn? Nothing, other than deep reinforcement learning is effective

We call it the digital sphinx

www.biorxiv.org/content/10.6...

3 weeks ago 396 147 9 26

New preprint from my lab! We study how reinforcement learning & selective attention interact. To do so, we built a set of models describing different ways that value & reward prediction error can modulate top-down attention. We compare model outcomes to monkey data from a color value learning task

1 week ago 93 32 2 1

The obvious answer here is that the student protest movement was broadly smeared as anti-semitic and aligned with terrorists, and a variety of institutions from government, media and the universities acted as if that smear was true, threatening, suspending, expelling and even deporting students.

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One week left to apply - come join us in New York this July!

An opportunity for trainees in theoretical/computational neuroscience to discuss their research and meet their peers.

1 week ago 4 2 0 0

The US/Iran war and escalating rhetoric are already disrupting civilian life and academic infrastructure across the region. We drafted a letter in defense of academic life, and to mobilize concrete support for affected students, scholars, and collaborations. Please check Sepi’s message and sign.

1 week ago 49 24 0 0
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Protect Academic Life in Iran We, the undersigned academics and researchers from around the world, express our profound concern over recent military strikes on Iran, the retaliatory responses, and the reported impact on civilian l...

Academic friends,
It's beyond heartbreaking to watch what's unfolding in Iran & the region.
A few of us drafted an open letter calling for protection of civilians & of educational, research, medical & cultural institutions.

Please read & sign if you agree:
sites.google.com/view/protect...

#IranWar

1 week ago 83 51 2 2

Excellent opportunity!

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Addressing degeneracy in rodent studies of cognition In order to relate neural dynamics to cognitive computations, it is critical to determine whether subjects are employing behavioral strategies that ac…

Excited to share our recent review, which highlights algorithmic and implementational degeneracy in studies of cognition: www.sciencedirect.com/science/arti...

2 weeks ago 39 13 0 0
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Apply for #FlatironCCN's Neural Data Analysis workshop at #FENS2026 before April 10! Learn more: https://www.simonsfoundation.org/event/ccn_fens2026/ #science #neuroscience

2 weeks ago 12 5 0 3
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Another great opportunity for trainees in theoretical/computational neuroscience!

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This is a great opportunity for grad students and postdocs to get hands-on experience with modern neural data analysis tools in Python

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Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN) Information Session (2026)
Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN) Information Session (2026) The Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN) aims to spark and sustain interest in neuroscience among undergraduate students who have not had access to research opportunities. SURFiN provides funds for paid research assistantshi...

Curious about our Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN) program? Watch our webinar recording and apply by April 21: www.youtube.com/watch #science #neuroscience

3 weeks ago 12 7 1 0
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Acetylcholine demixes heterogeneous dopamine signals for learning and moving Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...

Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...

3 weeks ago 155 68 2 3
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Trading places: What happens when neuroscience turns into machine learning, and machine learning turns into neuroscience? Neuroscience has become increasingly concerned with prediction, and machine learning with causal explanation, with each field adopting methods from the other. I asked eight experts to weigh in on what...

Neuroscience has become increasingly concerned with prediction, and machine learning with causal explanation, with each field adopting methods from the other, writes @gershbrain.bsky.social. Will this bring us closer to understanding neural systems?

www.thetransmitter.org/the-big-pict...

4 weeks ago 62 20 2 8
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New preprint: our lab’s first Alzheimer’s paper! “Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease”
www.biorxiv.org/content/10.6... 🧪🧵1/

1 month ago 100 28 5 4
Cosyne 2026 - Cosyne Tutorial: Comparative Analysis of Neural Population Codes
Cosyne 2026 - Cosyne Tutorial: Comparative Analysis of Neural Population Codes YouTube video by Cosyne Talks

Cosyne invited me to give a long tutorial (4 hours!) on methods to quantify differences high-d neural recordings across animals, brain regions, deep neural nets, etc.

The recording is up on youtube. I hope it inspires more research on this fundamental topic!

www.youtube.com/watch?v=n44x...

1 month ago 160 56 3 1
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Rainer Engelken | Join the Lab Uncovering theoretical principles of learning and computation in neural circuits, from single neurons to brain-wide systems.

We are recruiting PhD students and postdocs at UIUC ECE interested in learning dynamics, spiking networks, and dynamical systems. Details:
rainerengelken.github.io/join/

1 month ago 20 7 1 2
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Hopeless in Tehran Essays on neuroscience

Today I received a note from a grad student who lives in Tehran. Her note gives you firsthand experience of what it’s like to live in a city that is being bombed, and what it’s like to be young and feel despair about your future.

rezashadmehr.blogspot.com/2026/03/hope...

1 month ago 169 75 5 7
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Compact deep neural network models of the visual cortex Nature - Parsimonious deep neural network models can be used for prediction of visual neuron responses.

DNN models of the brain are getting bigger. Are we replacing one complicated system in vivo with another in silico?

In new work, we seek the *smallest* DNN models of visual cortex, balancing prediction with parsimony.

It turns out these compact models are surprisingly small!

rdcu.be/e5H8G

1 month ago 127 47 3 4
Circuits, Dynamics, and Computation in Social Behavior, COSYNE 2026 COSYNE 2026 Workshop: Circuits, Dynamics, and Computation in Social Behavior

Psyched to announce our COSYNE workshop on social behaviors (Mar 17th, Cascais). We have a stellar lineup of speakers on topics from animal cooperation and aggression to the social dynamics of LLM agents.

Co-organized with Libby Zhang (Allen Institute + UW).
cosyne-social-behavior.github.io

1 month ago 28 7 2 0
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I am totally pumped about this new work . "Task-trained RNNs" are a powerful and influential framework in neuroscience, but have lacked a firm theoretical footing. This work provides one, and makes direct contact with the classical theory of random RNNs:
www.biorxiv.org/content/10.6...

1 month ago 87 33 2 3
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Research Technician Research Technician position available in the Grienberger lab at Brandeis University. We are a new neuroscience group studying the cellular basis of learning and memory in the mammalian brain. This is...

We’re looking for a new Research Tech! Our research tech is heading to graduate school (very exciting!), which means we’re recruiting someone new to join our team. The position involves hands-on neuroscience research in a collaborative environment.
brandeis.wd5.myworkdayjobs.com/Jobs/job/Bra...

1 month ago 18 21 0 0

This obviously very stupid but is it also smart? We’ll talk to some liars after this break.

1 month ago 4173 743 10 12
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The U.S. Senate must be clear: no war with Iran.

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Excited to launch Principia, a nonprofit research organisation at the intersection of deep learning theory and AI safety.

Our goal is to develop theory for modern machine learning systems that can help us understand complex network behaviors, including those critical for AI safety and alignment.

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2 months ago 93 28 1 1

New preprint from the lab! Ábel Ságodi developed a theory of approximating dynamical systems that goes beyond finite time. #theoreticalNeuroscience
Follow @neurabel.bsky.social

Universal Approximation Theorems for Dynamical Systems with Infinite-Time Horizon Guarantees. . arxiv.org/abs/2602.08640

2 months ago 18 7 0 0
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News from central Jersey: I'm running to represent New Jersey's 12th Congressional District.

By entering the fray, I hope to bring ideas of repairing our frayed republic. Not only to defend it in 2026, but to build something stronger, for generations to come!

samwang.substack.com/p/entering-t...

2 months ago 531 151 33 34
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

New paper out at PNAS: www.pnas.org/doi/10.1073/...
Revisiting the high-dimensional geometry of population responses in the visual cortex with @jpillowtime.bsky.social. The review took forever because a reviewer was doubtful our new estimator can infer eigenvalues beyond the rank of the data! (1/6)

2 months ago 69 19 2 2
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Complementary cortical and thalamic contributions to cell type–specific striatal activity dynamics during movement Cell type–specific striatal activity during movement is shaped by cortical and thalamic inputs with complementary roles.

Our new work is out in Science Advances. We show that neural activity in the striatum reflects not just cortical inputs, but also often-underappreciated thalamic inputs.

www.science.org/doi/10.1126/...

2 months ago 44 8 0 0

As tens of thousands across America protest the violence that ICE sows with impunity, federal agents shot and killed another person in Minneapolis today.

ICE terrorizes our cities. ICE puts us all in danger. Abolish ICE.

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