I have met during my Erasmus Stay so wonderful people in Budapest! My Heart goes to all the great people there! 🫶🏻🇭🇺🇪🇺🗳️🎆

Oh. Stargirl. You are such a nice Person. There are Always mood Swings, where obvious Vitamin D, Spices & Tea might help, but i feel you. I guess you might need another Close friend or even an amazing animal to be Close. I also listen to music, do Gym, visit the library, meet roomies or call my mum.

How fast does a protein fold? Real-time technique captures the moment Proteins assume complex 3D shapes even faster than does DNA, which is a simpler molecule.

Scientists say they have made some of the first direct measurements of how long it takes an individual, ordinary protein to fold – and the results were surprising.

go.nature.com/3N4UrSD

In @jcb.org, Rodriguez Salazar, @caglaeroglu.bsky.social et al. show that Drp1-mediated mitochondrial fission is necessary for peripheral #astrocyte process formation. Loss of Drp1 induces astrocyte reactivity & disrupts cortical astrocyte organization rupress.org/jcb/article/...

🧬 Astrocyte Genes (help maintain the BBB from the brain side):

GFAP, AQP4, S100B, ALDH1L1, SLC1A2, SLC1A3 - markers of astrocyte activity, damage, and glutamate balance

They may appear in blood when there’s stress, injury, or inflammation.

🧠 Astrocytes protect the brain during viral infection! Lindman et al. (2025) show #astrocyte RIPK3 triggers serpins that preserve the blood-brain barrier & limit immune cell influx. RIPK3 deletion → lower survival, same viral load. 📖 https://www.science.org/doi/10.1126/scisignal.adq6422

Confocal microscopy photo of the cortex showing neurons and astrocytes

Confocal microscopy photo of the cortex showing neurons and astrocytes

Check out this cool astrocyte multitasking in the brain! It manages a blood vessel on one side while supporting a neuron on the other. Everything in the brain, from blood vessels to neurons, is interconnected! 🔬 🧠
#microscopy #Neuroscience

Learning-associated astrocyte ensembles regulate memory recall - Nature A study in mice shows that learning induces c-Fos expression in a subset of astrocytes in the hippocampus, and that ensembles of these learning-associated astrocytes are involved in the recall of memo...

Learning-associated astrocyte ensembles regulate memory recall

www.nature.com/articles/s41...

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphorylation and aggregation.

Research Spotlight 💡
New study shows #astrocyte reactivity in #Alzheimers depends on activated #microglia. PET imaging & biomarkers reveal microglia drive Aβ-linked astrocyte reactivity, tau pathology, and cognitive decline.
🔗 https://www.nature.com/articles/s41593-025-02103-0

We train our digital overlords.
But regard it like this.
Someone has to find the god, even If Humans creates that Someones AI with Glial Cells to figure everything out.

We are genetically designed to be curious. The other question is whether we create sustainable Information feedback loops. :)

CRY1 & PER2 Complexe with 3D printed Tree structures. ❤️⌛🧬

Also don't forget Werner von Braun, who majorly contributed to NASA.
The gift of Hitler towards the US, was John von Neumann, Wigner, Einstein, many physicists, engineers, and many more.
I hope we have this time more economical stability with human and rational oversight...

Sergei Korolev - Wikipedia

In fact all of the german V2-Rocket Programm Engineers went to aid of the Sputnik.
There was on the other hand after the 2nd world war e.g. in the company of Zeiss the quote "we take the brain" from US troups.
I still don't want to negate the brilliance of Sergei Korolev, Landau or the russ. Math.

Trying to Build a PDP-11 Supercomputer – Part 1 YouTube video by Usagi Electric

youtu.be/ufOHzGh-jbs?...

I am horrified by today’s announcement. I am absolutely disgusted by the way that the kind of science I, and my colleagues do – as physical scientists involved in research that is purposeful, focused on solutions to climate and sustainability challenges, that do have real economic value – is being weaponised against our colleagues in the humanities and the social sciences. The work that our colleagues in the humanities and social sciences do is incredibly important. We can do all the work in developing clean technologies we want, but if we don’t understand the barrriers to people purchasing that tech? It becomes useless. We need scholars who work in the arts, in the social sciences, who ask questions about who we are and why. We need these people not only so that they may publish their work – and it is fair to consider that esoteric at times – but so they may teach the next generation. Teaching should never be reduced to repeating what is contained in decades old textbooks, but must be based in active scholarship – in asking research questions of relevance to our times today, and to our society.

And in any case, can it really be any more esoteric than quantum physics? In my experience, when I look at the work of my colleagues in the humanities and social scientists, it is always far more based in the needs of now and here that anything. Science that has economic impact is already privileged in our funding system. It has access to funding through MBIE, both via Endeavour programmes and Smart Ideas funding. Health research has its own funding mechanism, through the Health Research Council. We could argue about the relative amounts of funding that are awarded through these different mechanisms, but the fact remains: the Marsden Fund is the only funding source that operates even-handedly across disciplines. The Marsden Fund is not a partisan beast. It was set up by Simon Upton, when he was the responsible Minister for the National Government in 1992. It was established to support research excellence – based on discipline specific assessment of what excellence is – because it has long been understood by scientists, and in scientific communities, that the path from fundamental research to impact is a long and unpredictable one. Trying to ‘pick winners’ when funding fundamental science is a fools task: the impact is real, but it is measurable only at a collective level.

The context we are currently in, with our Science and University funding systems being reviewed, is also important. There are significant changes on the cards in the next years, and we all understand that. Changes to the PBRF or to the overheads paid to our universities might change the overall equation in terms of funding the vital work done by the humanities and social scientist in Aotearoa New Zealand. But none of those decisions have yet been made public. As it stands, this decision is an outrageous indictment on the research funding system in Aotearoa, and our collective understanding of what scholarship is. Scientists who take pride in your work on ‘fundamental’, or ‘blue skies’ topics? Watch out. You will be next if we let this stand. “ Professor Nicola Gaston, FRSNZ Usual disclaimer that I am CD of MacD and currently funded by Marsden. I’m also really fucking mad but you don’t have to print that bit. Will go take a walk – thanks for the opportunity to comment. N

First thing written. Need to walk it off and then will write the longer follow up 🤷‍♀️

#MarsdenSchmarsden

Cool to see you in bsky! :)

Billig Strom sagen Leute nur außerhalb der Branche, die die Wertschöpfskette, Innovation, und die Historie dazu nicht kennen. An Praktikern/Experten mangelt es, die auch wirklich begabt Hand anlegen.

Wenn die Strombepreisung stimmt, dann sinken die Produktionskosten besonders in der Galvanisierung, und E-Mobilität. Sowie Stückzahl der Chips, Funk oder Renderings in den Grafikkarten. Erst dann sehen die Prognosen & Ausrichtungen in der Sitzung auch anders aus...

Das hätte auch parallel zur atomaren Stromerzeugung geklappt, und dabei tausende Stellenabbaus in Bosch, Zulieferern oder Automobilbranche verhindert.
Das muss man ehrlich zur aktuellen Klimapolitik sagen.

It is a reminder that NIH is, at its heart, a collection of dedicated humans - scientists, physicians and staff - all public servants trying their best to advocate for and support the rest of us 🇺🇸

How cancer hijacks the nervous system to grow and spread A new wave of research is unpicking the relationship between cancer and neurons — and looking for ways to stop the crosstalk.

www.nature.com/articles/d41...

Found: the dial in the brain that controls the immune system Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.

www.nature.com/articles/d41...

Microglia play beneficial roles in multiple experimental seizure models Seizure disorders are common, affecting both the young and the old. Currently available antiseizure drugs are ineffective in a third of patients and have been developed with a focus on known neurocent...

www.biorxiv.org/content/10.1...

Phagocytosis: The central role of the centrosome The centrosome decides which branch extending from the body of microglia will successfully engulf and clear away dead neurons.

elifesciences.org/articles/846...

Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming Strickland et al. find that human neutrophils organize pulsatile, self-extinguishing waves of leukotriene B4 to ensure robust homeostatic recruitment. Self-extinguishing waves are dependent on the act...

www.cell.com/developmenta...

Light-microscopy based dense connectomic reconstruction of mammalian brain tissue The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and res...

www.biorxiv.org/content/10.1...

Stress can disrupt memory and lead to needless anxiety — here’s how In mice, stress altered the way that the brain formed memories, resulting in an unnecessary fear response.

www.nature.com/articles/d41...

Neuroinflammation: An astrocyte perspective The diverse roles of astrocytes and their cell-cell interactions in neurologic diseases offer opportunities for their therapeutic targeting.

www.science.org/doi/10.1126/...

www.biorxiv.org/content/10.1...