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C–H bond halogenation: unlocking regiodivergence and enhancing selectivity through directing group strategies Organohalides represent a crucial class of compounds widely used as key precursors for organometallic reagents, bioactive molecules, and nucleophilic substitution reactions. The increasing prominence ...

👉 This review highlights recent progress in applying various functional groups, as directing groups in C–H halogenation reactions over the past 5 years.

#carboxylic acids
#aldehydes
#amides
#8-aminoquinoline
#N-oxides
#PIP
#pyridine
#heterocyclic systems

🔗 doi.org/10.1039/D5QO00372E

Explore a simple & efficient #formylation of pyrazolo[1,5-a]pyrazines at position 7 in this study by A. Kostyuk & co-workers. This approach broadens the chemical space of #heterocyclic systems with synthetic & biological potential!

🔬 Read more: www.thieme-connect.com/products/ejo...