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The Golden Elephant 🐘

@nanopore

Dumpster that reads: Empty When Full

Schrödinger’s dumpster

SEER at JPM24 SEER inc. is a company that bridges the gap between classic Mass Spec-based proteomics and Next-Generation Proteomics techniques by improving the sample using their Proteograph technology before putti...

SEER at JPM24. Bridging the gap between old-school Mass Spec proteomics and Next-Gen Proteomics #NGPS open.substack.com/pub/albertvi...

GitHub - marbl/HG002: A complete diploid human genome A complete diploid human genome. Contribute to marbl/HG002 development by creating an account on GitHub.

We are excited to release v1.0 of our HG002 genome benchmark today! Our goal with the Q100 project is to create a complete and perfectly accurate representation of the diploid HG002 genome to serve as a replacement for current variant-based benchmarks. More info here: github.com/marbl/HG002

How do you like

THIS Curve ….. ?! … 🧬

#Nanopore Seq

MEGA ReadLengths 🧬

Mb — Mb — Mb

🎊 WATCH THIS !!! 🎊

Great line-up of speakers in @nanopore #PAG31 workshop. You don’t want to miss @keygene.com presenting on the 🍌 pangenome. Details: nanoporetech.com/about/events...

Telomere length is vital to understanding human health, but current methods for measuring them leave much to be desired. A new preprint from Carol Greider describes a direct nanopore telomere profiling assay using ONT that is precise and cost effective, with applications in research and the clinic.

Nvidia and the biological revolution at JPM24 Nvidia presented at JP Morgan Healthcare 2024 and I’ll describe my highlights from the presentation below. They also had a Fireside chat at JP Morgan CES with an emphasis on what Nvidia calls the ��...

Two posts in one day for some #MLKDay reading today: Nvidia and the biological revolution at JPM24 open.substack.com/pub/albertvi...

Impact of genome build on RNA-seq interpretation and diagnostics www.medrxiv.org/content/10.1... 🧬🖥️

Another preprint comparing different #SpatialBiology technologies just published. I'll cover it in a long-form post in the next few days.

Some typical LongReads

Thank you @nanopore !

GitHub - LooseLab/readfish: CLI tool for flexible and fast adaptive sampling on ONT sequencers CLI tool for flexible and fast adaptive sampling on ONT sequencers - GitHub - LooseLab/readfish: CLI tool for flexible and fast adaptive sampling on ONT sequencers

We've put out a new version of readfish, our tool for Nanopore adaptive sampling. This is our v1.0 release and has a lot of improvements, tweaks and stability issues addressed. It has been in testing for a long time and works with all ONT platforms github.com/looselab/rea....

Watching the “telly dons” The British media with their flair for nasty nicknames call them "telly dons" -- quasi-celebrity academics and writers who work and publish in the high circles of top universities in the U.K. and the ...

The “telly don” dilemma—If an academic is too popular, they’re accused of dumbing down their subject, attention-seeking types. If they remain too aloof, they become the “elitist intellectual” separated from the real life issues of society #AcademicSky winnipegpublibrary.wordpress.com/2012/03/16/w...

Big Steps Towards Plant Breeding’s Holy Grail: Apomixis - Seed World US While apomixis has been pursued by plant breeders for decades, it has until now been far out of reach. Several major research breakthroughs recently, however, mean apomixis is much closer than ever t...

SeedWorld article about apomixis for plant breeding: Big Steps Towards Plant Breeding’s Holy Grail: Apomixis. An interview with Mary Gehring of MIT and KeyGene's Rik Op den Camp about the progress, genetics and perspectives for variety development
www.seedworld.com/big-steps-to...

Hope to Meet up

For our Next Mission ! 🚀

Excellent Curve

of the LongReadMaster

The Golden Elephant Curve

Thank you ONT !
@nanopore

Come hear what my group has been doing with the
Illumina #DRAGEN to advance low cost/high throughput genotyping at #PAG31 during the Illumina Workshop Monday 1/15, 4-6pm Room Palm 5-6. See Y'all there! www.illumina.com/events/confe...

Element's JPM comments by Molly He, CEO and Co-Founder.. www.elementbiosciences.com/news/element...

2024 -

Year of the Golden Elephant

#PanGenome
#NLRomics
#PlantBreeding

"NLRome dataset from 124 genomes of plants in the Solanaceae family" by @YuSugiharaY @amiralito_ @JiorgosKourelis #OpenPlantNLR #NLRbiology #plantscience doi.org/10.5281/zeno...

Hi Bluesky!
Looking forward to explore this new medium!
Cheers,
Taco Jesse

In #NextGenSequencing news, on the long-reads capable technologies, the serial number est. have now broken above the 1,000 mark for $ONTTF P2 PromethION instruments (1,049). This entire fleet now matches the throughput of the updated fleet of $PACB Revios (173).

Illumina at JPM24 Here are my highlights of the presentation that Illumina gave at JP Morgan in 2024. As an intro, Illumina is a Life Science Tools company that sells Next-Generation Sequencing (NGS) instruments and re...

Illumina at JPM24 open.substack.com/pub/albertvi...