Innovative microscope reveals full 3D molecular orientation in cells Two heads are better than one, as the saying goes, and sometimes two instruments, ingeniously recombined, can accomplish feats that neither could have done on its own.

phys.org/news/2025-02...

Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice - Scientific Reports Scientific Reports - Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice

www.nature.com/articles/s41...

Researchers discover a major driver of inflammatory pathology in autoimmune and chronic inflammatory diseases Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that pat...

medicalxpress.com/news/2025-02...

Some of the advances in autoimmune conditions such as this may bring real benefits soon, hopefully. There's also the continuing work on 'inverse vaccines' against autoimmune diseases.

www.cas.org/resources/ca...

A Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene Therapy A fluoropolymer, FD17, identified in a polymer library, exhibits exceptional serum stability and endosomal escape, enabling efficient mRNA delivery. FD17 facilitates the intracellular delivery of mRN...

advanced.onlinelibrary.wiley.com/doi/10.1002/...

More scary* mRNA delivery advances.

*exciting.

Two figures walk along a corridor lined with complex machinery. The worker says "Congratulations, sir! The most intelligent machine ever created is ready to change the world. Ten billion dollars well spent... What shall we ask it to do? " The billionaire replies "That's my business, not yours. Close the door on your way out." Now alone with the machine, the billionaire asteps closer and asks quietly "Can you Make people like me?" it says "No"

My latest cartoon for @newscientist.com

Researchers discover a major driver of inflammatory pathology in autoimmune and chronic inflammatory diseases Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that pat...

This could help a lot of people if it works out
medicalxpress.com/news/2025-02...

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬

The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy

www.biorxiv.org/content/10.1...

Editing scientific content for political purity is turning MMWR into a compromised propaganda organ.

And why are the propaganda squads at CDC replacing specifically H5N1 bird flu studies?

I’ve got some pretty serious fascism- and flu-related concerns about this.

A view of Mars from orbit over the northern hemisphere with swirling clouds stretching across the planet’s surface. These clouds appear wispy and layered, with subtle wave like patterns. They are denser near the terminator, where they take on a soft, diffused appearance, gradually thinning toward the illuminated regions. Near the center, the broad, circular Alba Mons is visible. The upper part of the image marks the terminator, while the lower part reveals Mars atmospheric limb.

Cool image of clouds over the Northern Hemisphere of Mars taken by CNSA's Tianwen 1

Full size & more info: flic.kr/p/2qKEu4g
Image Processing: Andrea Luck
Raw Image: CNSA/CLEP/PEC/MoRIC

2024-01-27 at 3230 km
From the left: Milankovic Crater, Alba Mons and Tempe Terra
North is up

If you have encountered pediatric interdigitating dendritic cell sarcoma (IDCS), indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases—please see short thread below & reach out to Sri Kosuri: #sarcoma #medsky #biosky

Honestly, if this keeps going, it will be the single biggest, stupidest, most damaging self-inflicted wound any country has ever inflicted on itself.

Outsiders exposed: powerful photos reveal the ruthless reality of homelessness A striking exhibition in St Albans reveals the harsh realities of homelessness through powerful black-and-white photography

Homelessness.

160,000 children in temporary accommodation.
Lack of permanent home contributing factor in death of 74 (if not many more) kids since 2019.
39,000 families & pensioners placed out of borough.
All @privateeyenews.bsky.social figures.

The St Albans exhibition is a timely reminder...

Also enjoyed going to see a film I hadn't had the slightest idea about before I actually saw it.

Very refreshing to not see any trailers for it whatsoever beforehand.

Front cover of Big Issue magazine with a woman holding a baby which is looking at the camera

Loise from the Outsiders project. She spent fours years sleeping rough in London with her baby, afraid of trying to get support due to the hostile environment. They lived on scraps of discarded food from bins, or which had been dropped on the ground.

Went to see Companion earlier this week. Good thriller, some heavy sci-fi themes handled adeptly, with black humour and excellent action. Sophie Thatcher was amazing.

Well shit.

A novel CAR T-cell therapy achieved an 82% response rate in lymphoma patients, demonstrating efficacy even at low doses.

by Park JH, Palomba ML (...) Sadelain M et 31 al. in J Clin Oncol #MedSky

📖 read the article: https://ascopubs.org/doi/10.1200/JCO-24-02424

Trump's FBI Pick Kash Patel Took Up to $5M in Stock from Chinese Ecommerce Giant Shein Donald Trump’s pick for FBI director told senators he has no plans to divest his shares, which his financial disclosure form says were received in exchange for consulting services.

SCOOP: FBI director nominee Kash Patel disclosed he received up to $5M in shares of a mysterious entity in the Cayman Islands called Elite Depot. Elite Depot is a parent organization of fast-fashion giant Shein, according to corporate records I reviewed www.wired.com/story/kash-p...

The N.I.H. will cut about $4 Billion from federal research grants that support cancer, virus and heart disease research.
This is a direct attack on science, and America's leadership in medical innovation.
This is the kind of "winning" they want? Seriously?

A US Treasury Threat Intelligence Analysis Designates DOGE Staff as ‘Insider Threat’ An internal email reviewed by WIRED calls DOGE staff's access to federal payments systems “the single biggest insider threat risk the Bureau of the Fiscal Service has ever faced.”

SCOOP: A US Treasury threat intelligence analysis has designated DOGE staff an ‘insider threat'. An internal email reviewed by WIRED calls DOGE staff's access to federal payments systems “the single biggest insider threat risk the Bureau of the Fiscal Service has ever faced.”

Federal judge blocks Elon Musk's DOGE from accessing sensitive US Treasury Department material Those records contain personal data such as Social Security and bank account numbers for millions of Americans.

BREAKING: A federal judge has blocked Elon Musk’s DOGE from accessing sensitive US Treasury Department material. He set a hearing for February 14th.

Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis REVERT (REVERse Transition) is presented, a systems framework developed to identify a reversion switch in the transition process of tumorigenesis through comprehensive attractor landscape analysis of...

advanced.onlinelibrary.wiley.com/doi/10.1002/...

This is fascinating research. Probably a long time till any treatment is possible, but reverting cancerous cells to healthy cells would be amazing.

Gotta love those politician's power thumbs.

This periodic table depicts the primary source on Earth for each element: from the Big Bang, massive stars, white-dwarf supernovae, merging neutron stars, low-mass stars, or other processes. In cases where two sources contribute fairly equally, both appear.

You've probably heard that "we are stardust," but this graphic breaks it down and tells you what kind of stars your dust came from--and which elements didn't come from stars at all. 🧪

svs.gsfc.nasa.gov/13873/

It's okay, RFK Jr will divert the billions of dollars saved into finally proving that AIDS is caused by boogying too hard and being gay.

The Government’s Computing Experts Say They Are Terrified Four IT professionals lay out just how destructive Elon Musk’s incursion into the U.S. government could be.

New: We spoke to government IT employees/contractors about DOGE. Their warnings were dire. The people who maintain the systems that keep the country working are terrified. "This is the largest data breach and the largest IT security breach in our country’s history—at least that’s publicly known."

Actions are going to meet consequences. Unfortunately, with infectious diseases and anti-vaxxers, it's usually the most vulnerable who face those consequences.

And the sequel, Hanniballet.