Conformational landscape of integrin α4β1 and its recognition of VCAM and conformation-stabilizing small molecules
www.researchsquare.com/article/rs-8...

Essential Role of Integrin-Linked Kinase in Keratinocyte Responses to Mechanical Strain
www.mdpi.com/1422-0067/27...

OptoTAT reveals microtubule acetylation as a rapid trigger for GEF-H1–mediated cell migration Deb Roy et al. introduce an optogenetic tool to rapidly induce microtubule acetylation in living cells. The study shows that microtubule acetylation direct

OptoTAT reveals microtubule acetylation as a rapid trigger for GEF-H1–mediated cell migration
rupress.org/jcb/article-...

Interplay between membrane protrusive activities and their adhesion strength regulates cell migration | Molecular Biology of the Cell Migratory cells can adopt membrane protrusions like blebbing or lamellipodia for efficient migration. The underlying mechanisms of how switching contributes to cell migration are not clearly understoo...

Interplay between membrane protrusive activities and their adhesion strength regulates cell migration
www.molbiolcell.org/doi/abs/10.1...

Oncogenic LPP facilitates focal adhesion maturation in response to mechanical tension and regulates the Hippo signaling - Oncogene Oncogene - Oncogenic LPP facilitates focal adhesion maturation in response to mechanical tension and regulates the Hippo signaling

Oncogenic LPP facilitates focal adhesion maturation in response to mechanical tension and regulates the Hippo signaling
www.nature.com/articles/s41...

In pursuit of FNAIT biomarkers: αVβ3 specificity falls short In this issue of Blood, Oosterhoff et al1 revisit a widely cited hypothesis: that maternal alloantibodies directed preferentially against integrin αVβ3, ra

In pursuit of FNAIT biomarkers: αVβ3 specificity falls short
ashpublications.org/blood/articl...

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins Key PointsAnti–HPA-1a antibodies exclusively recognizing integrin αvβ3 were not detected in maternal sera from patients with FNAIT.Anti–HPA-1a antibodies b

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins
ashpublications.org/blood/articl...

Cancer cell plasticity is viewed as a driver of therapy resistance. Here, we propose the concept of “Field-Oriented” Therapy—leveraging plasticity rather than merely enduring it. To learn more, read: aacrjournals.org/cancerdiscov...

Blood proteomics: insights from public data - Genome Biology The circulating blood proteome comprises soluble and cellular components that reflect physiological and pathological states across tissues. Advances in mass spectrometry and affinity-based proteomics ...

Excited to have contributed to this review on #BloodProteomics: link.springer.com/article/10.1...
Congrats to first author Asier Larrea Sebal and many thanks to @ypriverol.bsky.social for the invitation to contribute!

#Proteomics #BigData #OpenScience #Reproducibility

Today I would like to share a publication that is particularly meaningful to me. Our tribute to my late mentor, Richard Hynes, has just been published in Matrix Biology.
I hope you will take a moment to read and celebrate the legacy of an extraordinary scientist and mentor.
doi.org/10.1016/j.ma...

Faure, L. M., Gómez‐González, M., Baguer, O., Comelles, J., ... & Roca‐Cusachs, P. (2024). 3D Micropatterned Traction Force Microscopy: A Technique to Control 3D Cell Shape While Measuring Cell‐Substrate Force Transmission. Advanced Science, 11(46), 2406932. #EpithelialMechanics
buff.ly/Mpt1o3g

For those preparing for spring and spending long days outdoors 🌱
As the days get brighter and outdoor work picks up, it’s easy to forget just how strong the sun can be, even in the UK!
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KANK2 at focal adhesions regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism - Cell Communication and Signaling Cell Communication and Signaling - Integrins form focal adhesions (FAs) at the cell edge and fibrillar adhesions (FBs) located centrally. Talin1 is essential to FAs, while talin2 is found in FAs...

From our collaboration with Andreja Ambriović-Ristov and colleagues at @institutrb.bsky.social

KANK2 at focal adhesions regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism
link.springer.com/article/10.1...

Meningitis is back – and here is why | Devi Sridhar After two deaths, it’s right to be concerned and to discuss investment in public health. But our system is good and it’s working, says Devi Sridhar, chair of global public health at the University of ...

www.theguardian.com/commentisfre...

Two die and 11 seriously ill in meningitis outbreak at University of Kent Students in Canterbury given antibiotics for fast-acting and invasive meningococcal disease, says UKHSA Two people have died and 11 are reportedly seriously ill in hospital after an outbreak of a rare form of invasive meningitis at the University of Kent. The UK Health Security Agency (UKHSA) said it had provided antibiotics to students in the Canterbury area after it detected 13 cases of invasive meningococcal disease, a combination of meningitis and septicaemia. Continue reading...

Two die and 11 seriously ill in meningitis outbreak at University of Kent

Fascinating. The origins of life. Featuring Buzz Baum too @buzzbaum.bsky.social

In Our Time - Archaea - BBC Sounds How a discovery in the 1970s changed the theory of the origin of complex life on earth.

www.bbc.co.uk/sounds/play/...

Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery Abstract. The Open Targets Platform (https://platform.opentargets.org) is a unique, open-source, publicly-available knowledge base providing data and tooli

A bit late to this but this resource seems useful:

Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery

academic.oup.com/nar/article/...

PSMD14 drives melanoma cell survival and MAPK inhibitor resistance through histone H2A deubiquitination
www.biorxiv.org/content/10.6...

The Stiff Side of Cancer: How Matrix Mechanics Rewrites Non-Coding RNA Expression Programs
www.mdpi.com/2311-553X/12...

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties
www.nature.com/articles/s41...

AI succeeds in diagnosing rare diseases An artificial-intelligence system uses clinical data, genetic information and literature searches to suggest diagnoses and provides the underlying reasoning.

Nature news & views:
'AI succeeds in diagnosing rare diseases'
www.nature.com/articles/d41...

AI offers way to image and assess clinical cell samples The use of artificial intelligence in the clinic to image slides of cells enables the rapid assessment of cellular characteristics that might help with diagnostic decisions.

Nature news & views:
'AI offers way to image and assess clinical cell samples'
www.nature.com/articles/d41...

Bishop Island? Shipping them off to a resort and let the public decide?

Splice modulation of COL4A5 reinstates collagen IV assembly in an organoid model of Alport syndrome
insight.jci.org/articles/vie...

Linking molecular tension and cellular tractions: a multiscale approach to focal adhesion mechanics - Communications Biology Simultaneous mapping of tractions and molecular tension reveals how cells coordinate forces across scales, from whole-cell mechanics to polarized force transmission within individual focal adhesions.

Linking molecular tension and cellular tractions: a multiscale approach to focal adhesion mechanics
www.nature.com/articles/s42...

Paxillin is our #CellLineOfTheWeek! 🧫

Our stem cell lines & plasmids are available for just the cost of shipping to lower the barriers to scientific discovery and breakthroughs.

🚛 Hosted and distributed by @coriellinstitute.bsky.social & @addgene.bsky.social

Well at least that fits with your experience. Thanks for sharing

Thought HeLa would be faster 🤷‍♂️

Do you provide a stimulus to alter proliferation? Interested in the idea for our students too 😉👌