Tracking ongoing chromosomal instability using single-cell whole-genome sequencing Chromosomal instability (CIN) generates aneuploid genomes that are characteristic of most cancers. While bulk genome sequencing reveals historical CIN, it lacks the resolution to identify ongoing CIN ...

📢 New preprint out!

We are thrilled to introduce our framework to track #ongoingCIN by leveraging single-cell genomics and CIN signatures:

www.biorxiv.org/content/10.1...

🚨Chemo treatment upgrade!🚨

Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇

📢OUT TODAY @natgenet.nature.com

📰Predicting resistance to chemotherapy using chromosomal instability signatures.

By @jsneaththompson.bsky.social, @gmaci.bsky.social and colleagues.

⬇️

www.nature.com/articles/s41...

The days of one-size-fits-all chemotherapy are ending.

Researchers at our Institute, @cniostopcancer.bsky.social & Tailor Bio have developed a test that predicts resistance to common chemo drugs — paving the way for personalised cancer treatment.

Find out more 👉 www.cruk.cam.ac.uk/news/scienti...

The paper is published in @natgenet.nature.com. First authors: @bhernando.bsky.social, @jsneaththompson.bsky.social and Laura Madrid. With collaborations from Tailor Bio and @cam.ac.uk. 

Funding: @saludisciii.bsky.social @cienciagob.bsky.social  @cruk-ci.bsky.social  y @lacaixa.bsky.social

A pleasure to be at the fantastic #EACR2025 and present my research project! Looking forward for cool scientific discussions with amazing cancer researchers and friends @helloeacr.bsky.social @cniostopcancer.bsky.social @gmaci.bsky.social

Forecasting oncogene amplification and tumour suppressor deletion Oncogene amplification and tumour suppressor deletion can drive tumour initiation, progression and treatment resistance. Detection at diagnosis often signals poor prognosis, but it can also enable opp...

If tumour genome evolution is deterministic, can we forecast genomic changes? Yes we can! At least for oncogene amps and tumour suppressor dels. @bhernando.bsky.social Angel Fernandez-Sanroman present our method for forecasting driver gene copy number change. Preprint: bit.ly/4kxF14y ⬇️1/

Great work, Gonzalo!!

We are hiring! Opportunity for a project manager to oversee all aspects of a multi-centre clinical research project to implement an AI-based genomic test that predicts resistance to chemotherapy - Madrid, Spain. PM for more details. Deadline 25 January! www.cnio.es/en/empleo/re...