New preprint from the lab - using variance QTLs to identify GxE interactions in genetically-identical twins
@kingslsm.bsky.social
@kingscollegelondon.bsky.social

Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects Background Genetic variants that are associated with phenotypic variability, or variance quantitative trait loci (vQTLs), have been detected for multiple human traits. Gene-environment interactions ca...

New preprint by Xiaopu Zhang!
www.biorxiv.org/content/10.1...
@jordanatbell.bsky.social @ntrbiopsy.bsky.social

Impact of nutrition on molecular mechanisms of skin health This 4-year PhD studentship is in collaboration with Unilever and includes a 3-month research placement at Unilever’s King’s College London research laboratory and Unilever’s Liverpool laboratories.

I’m recruiting: 4-year BBSRC-funded PhD studentship in computational genomics of human skin, nutrition & ageing at @kingscollegelondon.bsky.social in collaboration w Unilever; co-supervised by @kerrinsmall.bsky.social

Fully funded stipend & tuition fees

Deadline 13 July 2025

tinyurl.com/2edmve5p

Doctors use poo pills to flush out dangerous superbugs Can a dose of good bacteria clear superbugs from their hiding place in the bowels?

Excited to see this trial published & related BBC feature
www.bbc.co.uk/news/article...

I was very peripherally involved, but it could be huge for antimicrobial resistance

Amazing work ‪Blair Merrick & Simon Goldenberg @gstt-nhs.bsky.social @kingslsm.bsky.social @kingscollegelondon.bsky.social

Want to use UK Biobank data to study ME/CFS? Can't decide which of the 5,354 UKB participants with evidence of ME/CFS to choose as cases? In this preprint, we consider what case/control definitions to apply. openresearch.nihr.ac.uk/articles/5-3... #pwME #mecfs

A spotted trunkfish goes SKKRRTTT in slow motion #spottedtrunkfish #swimminghandbag #trunkfish #boxfish #skkrrttt #slowmotion #coral #coralhead #coralcitycamera #miami #portmiami #biscaynebay #bfi #noaa #aoml #coralcity #civicpridethroughbiodiversity #glennnevis #coralcityfoundation #ccf #kbcf

Congratulations Graham!

The European brown hare is the only mammal with confirmed 'SUPERFETATION': multiple fetuses at different developmental stages, showing they're getting pregnant while ALREADY pregnant, which is separate from the more common phenomenon, multiple pregnancies in the same cycle, 'superfecundation'.

Interesting to see what happens when you include having kids as a covariate? I’m sure child related sleep deprivation likely contributes to this result!

#epigenomics25 up next @chiaraherzog.bsky.social talking about non-invasive breast cancer detection

#epigenomics25 now we have Sarah Hoelzl from TUM on epigenetics underlying sex bias in cardiovascular disease

#epigenomics25 now @danbelsky.bsky.social speaking about biological ageing

#epigenomics25 now @tuuliel.bsky.social speaking about functional interpretation of genetic variation

#epigenomics25 now Matt Silver from @lshtm.bsky.social talking about epigenetic silencing of a transposable element linked to Type 1 diabetes

#epigenomics25 Alexander Meissner from @molgen.mpg.de delivers the opening keynote on non canonical DNAm in development and tumours

It’s my birthday! It should be a happy day, but I can’t stop thinking about the personal domino effects that are likely to happen as a direct result of the drastic changes happening in our government. 1/n

Preventive cancer vaccines deliver tumor antigens or neoantigens, so that the immune system will attack tumor cells.

A new generation of cancer-preventing vaccines could wipe out tumors before they form.

Learn more on #WorldCancerDay: https://scim.ag/4gk8Qmo

A new resource rating >50,000 foods from 3 grocery stores
(Walmart, Target, and Whole Foods) for degree of processing and breakdown of ingredients
www.nature.com/articles/s43...
Website for consumers www.truefood.tech

Epigenomics of Common Diseases (hybrid conference) Dates: 12-14 March 2025 Location: Hinxton Hall Conference Centre, Wellcome Genome Campus, UK and online Bursary deadline: 10 December 2024 Abstract deadline: 14 January 2025 In-person registration deadline: 11 February 2025 Virtual registration deadline: 4 March 2025

Share your #epigenetics research at #Epigenomics25!

⏰Submit an abstract by 14 January

Participate in a global showcase of #epigenomic approaches for the study of common #HumanDiseases.

Present to global experts including @jordanatbell.bsky.social

Info➡️bit.ly/41tL5Vj

#PhDchat #AcademicChatter

Why don’t new memories overwrite old ones? Sleep science holds clues Research in mice points towards a mechanism that avoids ‘catastrophic forgetting’.

Why don’t new memories overwrite old ones? It appears that this is because the brain processes new and old memories in separate phases of sleep, which might prevent mixing between the two.

Full details in this nature paper www.nature.com/articles/s41...
🧪
www.nature.com/articles/d41...

Most smokers realise that smoking could shorten their life but not the impact of each cigarette they smoke.

The price of a cigarette: 20 minutes of life: 17 for men and 22 for women.

onlinelibrary.wiley.com/doi/10.1111/...

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

Research Assistant in Bioinformatics at King's College London Recruiting now: Research Assistant in Bioinformatics on jobs.ac.uk. Click for details and explore more academic job opportunities on the top job board

My first #job ad here! We are looking for a res assistant in #bioinformatics to analyse #single-cell and #spatial #transcriptomics data in #skin inflammation. Job based at King's College London, with opportunity to spend time at @ubcmedicine.bsky.social in beautiful Vancouver tinyurl.com/4xd9n5n7

Microplastics in the human body

"Twenty years of microplastic pollution research—what have we learned?"

www.science.org/doi/10.1126/...

Feel like most of my early career is just moments of pure luck- not sure that in today's financial climate I'd able to retrace it. Two examples- someone pulled out from a scholarship in Oxford & I was next in line :), went to a meeting in Hawaii (Hawaii!!) & met a future mentor who changed my career

Excited to announce our keynote speakers for #ECD25 12-14 March 2025 Wellcome Genome Campus UK:
Edith Heard (@embl.org @crick.ac.uk), @jonathanmill.bsky.social (#UExeter) and Xiaowei Zhuang (@harvard.edu)

Register bit.ly/3Da3AEd
#Epigenomics #SingleCell #Epidemiology @connectingscience.bsky.social

Mathematicians discover new class of shape seen throughout nature ‘Soft cells’ — shapes with rounded corners and pointed tips that fit together on a plane — feature in onions, molluscs and more.

Pretty darn cool!
www.nature.com/articles/d41...
h/t @thevillalab.bsky.social

Strong new evidence for T cell exhaustion in myalgic encephalomyelitis (ME/CFS) reflecting chronic viral infection, relevant to #LongCovid, and possible path to treatment candidates
www.pnas.org/doi/epub/10.... @pnas.org

Personalized progression modelling and prediction in Parkinson’s disease with a novel multi-modal graph approach - npj Parkinson's Disease npj Parkinson's Disease - Personalized progression modelling and prediction in Parkinson’s disease with a novel multi-modal graph approach

This publication today on multimodal #AI to accurately and precisely predict an individual's heath trajectory, in this case #Parkinson's disease, is a frontrunner for many to come
www.nature.com/articles/s41...