Thanks for the great example! So they argued that balancing selection operates within population and is fundamentally different from local adaptation which operates between population. We've seen this distinction be made in later work (i.e Charlesworth and Charlesworth 1997), but not originally.

We are revising this ms www.biorxiv.org/content/10.1... and responding to reviewers who liked the paper but had issues with how we thought of balancing selection and its relationship to ecological, local adaptation 1/n

Genotype-fitness mapping of adaptive mutants reveals shifting low-dimensional structure across divergent environments Predicting the effect of a genetic mutation on fitness is a major challenge in evolutionary biology. This study uses fitness effects of a large collection of adaptive yeast mutants in multiple lab env...

Really excited that this major work from my PhD is finally published in @plosbiology.org ! In it, we were trying to tackle a fundamental question in evolution - how do genetic mutations map onto evolutionary fitness? (1/n)
journals.plos.org/plosbiology/...

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

Bruce Springsteen - Streets Of Minneapolis (Official Audio) YouTube video by Bruce Springsteen

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.

Stay free

The Abreu lab at NYU is hiring another postdoc! We study microbial ecology and evolution, using yeast/bacteria microcosms, DNA barcoding for evolutionary lineage tracking, and simple mathematical modeling. Apply here: apply.interfolio.com/179949

We’re very happy to share the results from the last chapter of my PhD, now out as a preprint on bioRxiv
www.biorxiv.org/content/bior...

Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...

One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.

www.biorxiv.org/content/10.1...

1/n 🧵 Excited to share our new paper! We developed a framework to reveal hidden simplicity in how organisms adapt to different environments, particularly focusing on antibiotic resistance evolution. #EvolutionaryBiology #MachineLearning

My NSF PRFB on the genetics of female polymorphism in hummingbirds was terminated yesterday.

I don't have much to say, I'm just sad. We've discovered so much, and could have gone so much further.

If anyone else is in the same boat, esp postdocs, please reach out, it would be good to connect.

5 relative abundance plots arranged to have increasing compositional variability (variability across relative abundance samples, here vertical bars)

1/ Hey y'all, I'm excited to share my latest paper, which is out now in PNAS! We introduce FAVA, a statistical framework to measure compositional variability across microbiome samples. If you want to measure variability across a stacked bar plot, FAVA is for you! Paper: doi.org/10.1073/pnas...

I’m thrilled to share my first ever publication, now published in PNAS! www.pnas.org/doi/10.1073/...

With mentorship from the amazing @ksxue.bsky.social, I looked at how the outcomes of species introductions to microbial communities are influenced by the number of introduced microbes.

Dominance reversal maintains large-effect resistance polymorphism in temporally varying environments A central challenge in evolutionary biology is to uncover mechanisms maintaining functional genetic variation1. Theory suggests that dominance reversal, whereby alleles subject to fluctuating selectio...

How is functional variation at large-effect loci maintained in natural populations?

Thrilled to share our work showing how beneficial dominance reversal helps fruit flies maintain a resistance polymorphism as selection varies in their environment! A thread 🧵 1/n

www.biorxiv.org/content/10.1...

To measure the selective and dominance effects of the resistant Ace alleles on fitness in a semi-natural context, we used Paul Schmidt & @petrovadmitri.bsky.social powerful system combining field mesocosms with large-scale phenotypic and genomic measurements (Rudman et al 2022) 9/n

Diverse phage communities are maintained stably on a clonal bacterial host Bacteriophages are the most abundant and phylogenetically diverse biological entities on Earth, yet the ecological mechanisms that sustain this extraordinary diversity remain unclear. In this study, w...

Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵 www.science.org/doi/10.1126/...

Apologies for linking the other place, I wanted to be able to tag everyone who was involved. I'm hoping that as a community we eventually decide that BlueSky becomes the default platform for sharing new results.

Huge thanks to all my co-authors including @mrebolleda.bsky.social and @jgoldford.bsky.social who are on here and all the others who are not . Here's a link to a longer thread explaining this work. twitter.com/jccvila/stat...

1st post on here to share our new preprint: ‘Metabolic similarity and the predictability of microbial community assembly’. Metabolically similar carbon sources lead to predictably similar growth rates and by-products which leads to predictably similar communities
biorxiv.org/content/10.1... .