RNA in physiology and disease | Genetics Society Meeting background RNA molecules are at the heart of normal physiological processes, and their dysregulation can drive a wide range of human diseases. This international meeting will bring together wo...

Have a look at this fantastic meeting and save the date!

The “RNA in Physiology and Disease” conference, hosted by @gensocuk.bsky.social, will take place 7–9 September 2026 in Newcastle, UK.

genetics.org.uk/events/rna-i...

Construction of complex and diverse DNA sequences using DNA three-way junctions - Nature Sidewinder enables high-fidelity DNA assembly by separating the information that guides assembly from the final assembled sequence.

Sidewinder uses DNA three‑way junctions (3WJs) to construct long, complex, and highly diverse synthetic DNA sequences. #NBThighlight www.nature.com/articles/s41...

Very excited to share this Nature Comms publication: "Enhancing autophagy by redox regulation extends lifespan in Drosophila". From @cochemelab.bsky.social et al @imperialcollegeldn.bsky.social @ucl.ac.uk @mpiage.bsky.social. Congrats to all involved! #Redox #aging www.nature.com/articles/s41...

Cellular responses to RNA damage RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

RNA damage isn’t trivial—cells evolved responses to it. Ribosome stalling at damaged RNA triggers stress signaling, impacting inflammation, cell cycle, and tumor suppression. Could RNA repair be the next medical frontier?

Cell: ”Cellular responses to RNA damage”
www.cell.com/cell/fulltex...

Rapid promoter evolution of male accessory gland genes is accompanied by divergent expression in closely related Drosophila species Abstract. Seminal fluid proteins (Sfps) are essential for reproductive success and evolve fast on average, possibly driven by post-copulatory sexual select

Last of the trilogy about core promoter evolution thanks to @davidmcquarrie.bsky.social
academic.oup.com/genetics/adv...

Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model - Scientific Reports Scientific Reports - Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model

Making beta to alpha - see our latest work here pinning honey bee nicotinic acetylcholine receptor alpha8 gene into flies to test neonicotinoid sensitivity thanks to @annalassota.bsky.social and @docfly.bsky.social
www.nature.com/articles/s41...

Congratulations!!🥳

Females are larger than males. How? Here is one solution- they have MORE nuclei in their flight muscles and grow LARGER heart and fat body cells with MORE ribosomal mRNAs. Fun collaboration of @jeromeavellaneda.bsky.social with @soumitrakp.bsky.social & Brian Oliver www.biorxiv.org/content/10.1...

Photoactivatable RNA Tags for Subcellular Photolabeling of RNA Photoactivatable fluorescent proteins enable precise analysis of subcellular protein dynamics, but a comparable approach for photoactivated tagging subcellular RNA remains lacking. Here, we develop PA...

pubs.acs.org/doi/abs/10.1...

Male quality assessment: Venerose seminal fluid sugar sensed by female brain neurons after mating. See our comment thanks to @deepanshund.bsky.social about an exiting story from the Young-Joon Kim lab.
www.tandfonline.com/doi/epdf/10....

N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs In humans, misprocessed mRNAs containing intact 5′ Splice Site (5′SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K, a ...

N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs

www.biorxiv.org/content/10.1...

Excited to share our new paper describing how ELAV/Hu RNA binding proteins achieve binding specificity now in NAR thanks to fantastic @davidmcquarrie.bsky.social
academic.oup.com/nar/article/...