Join the GTA for an upcoming webinar with Dr. Duong Bui (University of Alberta) on using native mass spectrometry and glycoproteomics to study how glycans regulate immune signalling and contribute to disease.
📅 Jan. 27, 11AM
🔗: https://canadianglycomics.ca/training/webinar-series/

#Glycotime

🌟 The Bui Lab at the University of Waterloo is recruiting graduate students (MSc or PhD)!
uwaterloo.ca/chemistry/ou...

Logo of the Glycomics Institute of Alberta, featuring the Glycogang, characters made from the symbolic nomenclature of glycans.

Save the date for #GIA2026 (Nov. 5-6, 2026) which will feature free #glycotime talks by @carolynbertozzi.bskyverified.social , Dr. Mia Huang and more!

The countdown is on! With GIA2025 less than 3 weeks away, we’d like to introduce our Keynote Speakers that we will have the privilege of hosting this year. First is Dr. Sriram Neelameghan from the University at Buffalo whose lab studies the area of Systems Glycobiology. @neel-lab.bsky.social

Excited to share that our latest paper is now published in JASMS!
pubs.acs.org/doi/10.1021/...

Chemoenzymatically Synthesized O-Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context Gangliosides are a class of sialic acid-containing glycosphingolipids involved in a wide range of biological processes. The terminal sialic acid of gangliosides can be O -acetylated at C7 and/or C9 hy...

#glycotime alert! Zhiyong synthesized O-acetylated GD3 gangliosides, which were used to examine viral receptor specificities in a cellular context by @LiangRuonan great work by @zeshi_li and @TheBoonsGroup @uu-cbdd.bsky.social www.biorxiv.org/content/10.1...

Analyzing the miRNA regulatory landscape of OGT identifies evolutionarily conserved upregulation. O-GlcNAc transferase (OGT) is the key enzyme involved in post-translationally modifying cytoplasmic and nuclear proteins with O-GlcNAc. Maintenance of cellular O-GlcNAcylation levels is critical to ce...

Preprint: upregulation by #miRNA conserved for millions of yrs. Site on #OGT in multiple CLIP studies- upregulates protein. 8th gene in lit where we identified upreg. sites. Proud of Zainab Ali, @faezehjame.bsky.social, Hallie Ng, and Thu Chu #RNAsky #RNA #glycotime
www.biorxiv.org/content/10.1...

Inspired by Gary Van Berkel's work (DOI: 10.1016/S1044-0305(01)00264-1), we visualized flow using dyes, recorded videos with a smartphone camera, and analyzed grayscale intensity using MATLAB scripts.

Key findings:
Diffusion is the dominant force for mixing and, together with advection, drives bulk transport.
Differential electrophoretic motion contributes negligibly at typical nanoESI voltages.

Using a custom dual-emitter setup and a panel of dyes varying in size and charge, our talented undergrad researcher, Simar Dhillon, dissected these processes.

Going with the Flow: Mechanistic Insights into Slow Mixing Mode Native Mass Spectrometry Slow mixing mode native mass spectrometry (SLOMO-nMS), which monitors the mixing of layered solutions within a nanoflow electrospray ionization (nanoESI) emitter, enables robust quantification of biom...

#TeamMassSpec — Ever wondered what governs mass transport and mixing inside nanoESI emitters?
📢 Here, we report the first quantitative investigation of the factors driving solution mixing and analyte transport in a nanoESI emitter:
chemrxiv.org/engage/chemr...

Direct Ambient Mass Spectrometry for Food, Beverage, and Agricultural Sample Analysis and Research Ambient and direct mass spectrometry (MS) methods are becoming increasingly used for the rapid analysis of food, beverage and agricultural samples. Novel ionization approaches combined with targeted,...

Direct Ambient Mass Spectrometry for Food, Beverage, and Agricultural Sample Analysis and Research #MassSpectromRev analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

While rooted in glycobiology, the concepts and workflows apply broadly to all types of biomolecular interactions.
🟢 We’re especially grateful to the University of Alberta for supporting open access, making this work freely available to the community.

This paper outlines the fundamentals, challenges, and solutions for using nMS to study non-covalent biomolecular interactions. From basic binding assays to advanced troubleshooting strategies, we aimed to make this a go-to reference for the field.

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry Interactions between glycan-binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan i...

🚨 Just published in Mass Spectrometry Reviews! 🚨
Thrilled to share our latest review, summarizing over 20 years of work from the Klassen lab —plus insights from my own PhD research on COIN-nMS, SLOMO-nMS, and charge detection MS.
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

Schematic representation of the 14 human siglecs, 4 evolutionarily conserved on the left, with low sequence similarity, and 10 on the right sharing a higher sequence similarity to CD33. Siglec-6 is highlighted in yellow as it is the focus of this work. This is Figure 1 in the paper

When glycan recognition is linked to immune response, you need fine tuning! 😎

Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️

doi.org/10.1101/2025...

By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.

#ASMS2025 was a wonderful #TeamMassSpec experience. Our session chaired by @lingjun2025.bsky.social was awesome with great talks. Having the shuttle buses arranged was an incredibly thoughtful touch.
My personal version of Faces of MS this year:

Mass spectrometry post-doc position in Switzerland | Valerie Gabelica 🔊 Mass spectrometry post-doc position in Switzerland Join our dynamic and interdisciplinary team for a post-doc in Geneva, Switzerland, where we develop advanced mass spectrometry methods for biophysi...

Mass spectrometrist looking for a postdoc? Why not in Switzerland 🇨🇭
We are reinforcing our team in Geneva ⤵️
www.linkedin.com/posts/valeri...