Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - Nature Immunology One of three back-to-back papers to show dosage of BACH2 can modulate T cell differentiation and function and how we might apply this to enhance chimeric antigen receptor T cell therapies for cancer.

Amazing study from @RoychoudhuriLab highlighting the next-gen genetic manipulation to tweak the right amount of protein expression to enhance T cell function in cancers. Kudos to the authors.
Check it out : www.nature.com/articles/s41...

#tcellexhaustion #tcells

Early methionine availability attenuates T cell exhaustion Nature Immunology - The tumor environment is nutrient deficient. Here the authors show that early availability of methionine is critical for optimal T cell activation and prevents...

Thrilled to share our story published in @natimmunol.nature.com
We discovered a previously unknown metabolic regulatory event of T cell activation that affects their fate, providing a new perspective on T cell exhaustion. @stjuderesearch.bsky.social

Article: rdcu.be/exxhD

#Tcell #immunometabolism

Metabolites as Signals in Immunity and Inflammation Metabolites as Signals in Immunity and Inflammation describes the revolution in the definition of the word metabolism, highlighting changes in thinkin

Check out our chapter on ‘Adaptive Immunity and Metabolism’, in a recently published book by @elsevierconnect.bsky.social , highlighting the current understanding of how metabolites regulate adaptive immune system development and their response in diseases.
#immunometabolism

tinyurl.com/268f6sad