Cognitive impairment affected 32% of patients at 9 months, rising to 36% at 2.6 years post-infection.

Cognitive symptoms doubled from 27% to 53%. Risk factors: older age, hospitalization, female sex. MoCA scores declined 1.3 points over time in Italian cohort. (n=118) #LongCovid

"High prevalence of obstructive sleep apnea in patients with Long-COVID" - PubMed In this single-center, clinic-based LC cohort, OSA diagnosed by in-lab PSG was highly common. Given that OSA is treatable, a sleep study should be considered in LC patients even in the absence of daytime sleepiness or in the presence of insomnia.

Sleep apnea was detected in 84% of patients tested, with 31.5% having severe cases.

Neither daytime sleepiness nor other symptoms correlated with apnea severity, except insomnia. Sleep studies may help even without typical apnea symptoms in hospital clinic obs study. #LongCovid

Restrictive lung disease persisted in 43% of hospitalized patients one year post-discharge.

At 1 month, 76% had lung restriction. After 12 months, 32% still affected. Physical performance improved but 15% maintained functional limitations in prospective cohort. (n=62) #LongCovid

Native T1 is independently associated with aerobic exercise capacity in long-term follow-up after mild initial COVID-19 disease (Impression COVID&Heart Study) - PubMed In long-term follow-up of individuals with mild initial COVID-19 and no prior structural heart disease, aerobic capacity relative to predicted values was reduced in 48% of participants, particularly in men, and was independently associated with higher myocardial native T1. Native T1 and resting lact …

Higher heart inflammation (native T1) independently predicted lower exercise capacity 4 years after mild infection.

48% had below-predicted aerobic fitness, especially men. Each ms increase in T1 linked to 0.25% lower VO2peak in German obs study. (n=132) #LongCovid

Distinct plasma proteome signature at 3 months post-COVID-19 infection irrespective of post-COVID condition - PubMed Persistent symptoms following SARS-CoV-2 infection are the hallmark of post-COVID condition (PCC), also referred to as long COVID. However, the underlying molecular mechanisms remain poorly understood. In this study, we employed data-independent acquisition mass spectrometry (DIA-MS)-based plasma pr …

Plasma proteins remained altered 3 months post-infection in all previously infected vs uninfected controls.

Patients showed higher oxidative stress markers (VNN1, PON3), lower antioxidant PRDX6, elevated DNA damage. #LongCovid

A digital cognitive assessment tool (VMTech) will be validated against standard neuropsychological tests.

Protocol describes planned comparison of cognitive performance between those with vs without persistent symptoms, ages...

📄 www.medrxiv.org/content/10.64898/2026.04...

Self-reported anxiety, depression, and health-related quality of life during two years following hospitalization for covid-19: a longitudinal study - PubMed Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Health-related quality of life (HRQoL) has been observed to decline after COVID-19 hospitalization, with anxiety and depression contributing to reduced HRQoL and empha …

Anxiety symptoms remained stable while depression increased between 3-12 months post-hospitalization.

Those with moderate initial infection reported higher anxiety and pain vs severe cases at 2 years. Older age linked to lower quality of life in Swedish longit. study. #LongCovid

Higher education and full-time employment linked to better quality of life scores in patients, independent of medical conditions.

98% of education's benefit and 89% of employment's benefit remained unexplained by comorbidities....

📄 www.medrxiv.org/content/10.1101/2024.02....

Designing Nutrition Studies for Long COVID and Related Infection-Associated Chronic Illness: Qualitative Insights From a Patient-Reported Evaluation of Ketogenic Metabolic Therapy - PubMed Findings suggest nutrition trials for infection-associated chronic illnesses, including Long COVID, should consider incorporating longer intervention periods, multicomponent design, patient-centered outcomes, lived-experience integration, and tailored supports to optimize feasibility and impact.

Ketogenic diet program improved symptoms for 41 patients with chronic post-viral conditions

12-week virtual program combined diet with lifestyle changes. Participants (90% women, avg age 41) reported better energy and function. #LongCovid

Implementation of an interdisciplinary research model at a tertiary University Hospital in São Paulo, Brazil: post-COVID-19 cohort study - PubMed This study describes the implementation of an interdisciplinary model within the COVID-19 cohort at Hospital das Clínicas, Universidade de São Paulo (HCFMUSP). Among 1957 survivors, 749 attended the first follow-up (6‒11 months), revealing that 83% reported persistent symptoms ‒ mainly fatigue, dizz …

Hospitalized survivors struggle with persistent symptoms months after recovery

83% of 749 patients (from 1957 survivors) reported ongoing issues 6-11 months later. Most common: fatigue, dizziness, pain, breathing problems. #LongCovid

Mapping global evidence on compassion fatigue among healthcare workers during COVID-19: insights and implications for future preparedness - a scoping review - PubMed Compassion fatigue is a multifactorial, context-dependent hazard disproportionately affecting vulnerable HCWs. Effective mitigation requires longitudinal research, inclusive global representation, and multi-level strategies linking individual resilience with organisational reform and policy action t …

Compassion fatigue affected 20-87% of healthcare workers during pandemic, highest in nurses and frontline staff.

Risk factors: high workload, long shifts, repeated death exposure. Interventions showed small-to-moderate benefits in 21-country scoping review. (n=56) #LongCovid

Cognitive deficits improved to normal levels after one year despite persistent smell loss.

Initially impaired attention, memory, executive function, language & psychomotor speed recovered to match healthy controls in patients with ongoing smell dysfunction in longit. #LongCovid

HKU1 immune imprinting is associated with post-COVID symptoms after SARS-CoV-2 infection - PubMed The long-term health burden of SARS-CoV-2 infections remains poorly understood. In a cohort from Vancouver, Canada, we identified immune imprinting to endemic β-human coronaviruses (HCoVs), reflected by affinity-matured IgG responses that cross-reacted with the SARS-CoV-2 spike with low affinity, al …

Prior immunity to common cold coronavirus HKU1 was linked to greater likelihood of post-COVID symptoms.

Higher HKU1 antibodies and complement activation tracked with more symptoms, despite fewer infections in Vancouver cohort. #LongCovid

A quantitative metabolic signature of host response during SARS-CoV-2 infection and recovery - PubMed COVID-19 has individualized disease trajectories during both acute infection and long-term recovery ("long COVID"), highlighting the need for biomarkers for the disease's heterogeneity. In this study, we introduce "metabo-time," a quantitative metabolic signature derived from serum metabolites and l …

A blood metabolic signature tracked individual recovery patterns better than time alone.

The "metabo-time" marker disrupted during acute infection, normalized during recovery, and predicted when oxidative stress would resolve in patients across multiple cohorts in... #LongCovid

Older adults with persistent cognitive problems show higher depression and fatigue than healthy peers

Brain scans reveal inflammation markers elevated across all regions in 3 patients vs 3 controls. #LongCovid

Asthma control and exacerbation risk following SARS-CoV-2 infection in the post-acute COVID-19 phase: a systematic review - PubMed Asthma control and exacerbation risk following SARS-CoV-2 infection in the post-acute COVID-19 phase: a systematic review

Asthma exacerbations increased 2-5x after hospitalized COVID, but control mostly recovered over time.

Short-term control worsened 1-3 months post-infection. Non-hospitalized cases showed lower risk (~2x). No sustained deterioration found in syst review. #LongCovid

Long term cardiovascular effects on COVID-19 infection in children. The need for monitoring - PubMed Even in the absence of overt cardiovascular disease, children with prior SARS-CoV-2 infection experience persistent subclinical cardiac changes and symptoms consistent with Long-COVID. These findings highlight the need for ongoing surveillance and comprehensive cardiovascular assessments in pediatri …

Children showed persistent subclinical heart changes up to 1 year post-infection vs healthy controls.

Reduced left ventricular strain despite normal standard echo. 23.6% reported long-term symptoms (fatigue 16.6%). #LongCovid

Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers - PubMed This study was a cross-sectional and could not distinguish pathological abnormalities. However, as correlations of neuropsychological long COVID with specific brain regions and plasma biomarkers have been elucidated, conducting a case-control analysis may be worthwhile.

Brain fog symptoms tracked with specific brain blood flow changes and nerve damage markers in plasma.

Cognitive scores correlated with altered occipital lobe blood flow. Anxiety/depression linked to reduced parietal flow. #LongCovid

ME/CFS and long COVID showed opposite immune patterns despite similar symptoms.

Long COVID: persistent immune activation with exhaustion signs. ME/CFS: immune suppression with reduced activation markers. #LongCovid

📄 www.medrxiv.org/content/10.64898/2026.04...

Pre-infection symptoms and functional impairments did not significantly affect long COVID risk.

Higher risk linked to older age, female sex, Black identity, earlier variants, non-vaccination, and lower pre-infection...

📄 www.medrxiv.org/content/10.1101/2025.08....

Pulmonary embolism, abnormal breathing, fatigue, hemorrhagic stroke, memory loss/brain fog, and palpitations occurred more often after COVID vs other respiratory viruses.

Most other post-acute symptoms showed similar rates across...

📄 www.medrxiv.org/content/10.64898/2026.04...

Interdisciplinary Pediatric Long-COVID Care: A Descriptive Study of Interventions and Health-Related Quality of Life - PubMed Pediatric patients with long-COVID report high symptom burden. This study describes patient characteristics, care delivered and provides a novel description of symptom severity. Future research among more diverse populations is needed to evaluate outcomes of this integrative care.

Children's post-infection symptoms worse than cancer, chronic pain patients on quality of life scores

214 kids (avg age 15) at specialty clinic: 85% had fatigue, 75% headaches, 65% dizziness. Sleep, anxiety, depression scores higher than national averages. #LongCovid

Correlates of patient interest in rehabilitation psychology services among individuals with long COVID: A cross-sectional analysis - PubMed Anxiety symptoms and cognitive difficulties are key correlates of interest in rehabilitation psychology services, underscoring the value of early screening and targeted intervention. Stigma and prioritization of medical concerns may limit engagement, highlighting the importance of psychoeducation an …

Over half (57%) of patients expressed interest in rehabilitation psychology services.

Anxiety symptoms and cognitive difficulties were key drivers. Interest in individual therapy linked to depression, poor sleep, lower cognitive function in US cross-sectional study. #LongCovid

Ten inflammatory and neurology proteins distinguished patients from both recovered and healthy controls.

IL-20, HAGH, NAAA, CLEC10A, LXN best separated from healthy; MCP-1, TRAIL, G-CSF, NBL1, CCL23 from recovered. #LongCovid

Evolution with age of the relationship between sex and post-COVID symptoms: a population-based cohort study - PubMed Women are a target population in post-COVID symptoms management, especially among younger adults. Sex and age-dependent mechanisms attributable to SARS-CoV-2 infection may be involved in post-COVID symptoms.

Women were 2x more likely than men to report persistent symptoms after Omicron infection.

Age modified this gap: women under 35 were 3.5x more likely vs men, dropping to 1.7-1.8x in older groups. Pattern unique to infected vs uninfected in French cohort. (n=39,334) #LongCovid

Prepandemic Risk Factors for Disabling Long COVID: A Prospective Cohort Analysis - PubMed Prepandemic health, socioeconomic and psychological vulnerabilities were independently associated with disabling long COVID, with distinct sex-specific patterns of risk.

Poor sleep quality before infection nearly doubled risk of developing disabling long COVID.

Very bad sleep: 96% higher risk. Psychological distress: 44% higher risk. Women 26% higher risk than men. White participants 25% lower risk vs non-White in UK cohort. #LongCovid

Stellate Ganglion Block in the Treatment of Long COVID: A Systematic Review - PubMed Stellate ganglion block is a promising treatment that appears to generate substantive benefit for many of the symptoms seen in long COVID. However, the current literature has small, uncontrolled studies with heterogenous study designs and follow-up periods. Standardized research with larger sample s …

Stellate ganglion nerve blocks were linked to symptom improvement across 7 uncontrolled studies.

Response rates ranged 56-100%. Most robust relief (>80% reporting benefit) for cough, breathing difficulty, headache, joint pain, pins/needles in syst review. #LongCovid

Nasal nitric oxide in post-acute COVID-19 cough: A comparison with chronic cough and the role of current allergic rhinitis - PubMed Post-acute COVID-19 cough (PACC) is a persistent or recurrent cough lasting >3 weeks after SARS-CoV-2 infection without other causes. This study examined nasal nitric oxide (nNO) in PACC patients to evaluate diagnostic and treatment potential. In this retrospective study, we enrolled 156 PACC pat …

Higher nasal nitric oxide in post-COVID cough was explained by concurrent allergic rhinitis, not the cough itself.

61% of post-COVID cough patients had allergic rhinitis vs 37% of chronic cough patients. #LongCovid

In rheumatic disease patients, aminopeptide supplements were linked to 8.5x higher symptom remission vs controls.

64% vs 23% achieved remission. Fatigue improved 9x more often (68% vs 28%). CD3+ and CD8+ T cells increased in China retro cohort. (n=171) #LongCovid

Acute COVID-19 severity and impaired cognitive function up to 32 months after diagnosis: an observational study - PubMed The data indicates that a severe COVID-19 acute illness course is associated with impaired cognitive function up to 18-32 months after COVID-19 diagnosis.

Severe acute illness predicted cognitive impairment up to 32 months after infection.

Those bedridden ≥7 days had 2.6x higher prevalence of brain fog vs never-infected. Non-bedridden cases showed lower prevalence in 4-country European obs study. (n=153,841) #LongCovid