Interested in aging and rejuvenation?
We have a new Research Assistant position to understand aging at the cellular level!!
Come join our team!!! 😎
careersearch.stanford.edu/jobs/life-sc...
Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
CryoET and colored segmentation of TMEM106B fibrils protruding from within a broken lysosome in post-mortem FTLD-GRN brain.
Excited to share a pre-print from a collaboration between my lab at NIH, Len Petrucelli's lab at University of Miami, and Shyamal Mosalaganti's lab at University of Michigan.
Have you ever wondered why mice do what they do when they are free to do whatever they want? Check out our latest (and this slightly delayed thread about our recent paper, led by Caleb Weinreb and friends...) www.cell.com/neuron/fullt...
So very sorry for your loss, Rebecca.
Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social
doi.org/10.1038/s435...
Aging may feel gradual… but what if it’s not?
In our recent paper, we tracked fish continuously from puberty until death.
This gave us a unique view of how aging unfolds across the adult lifespan.
🧵
Great work from Claire, Ravi, and the whole team– the initial lifelong continuous screen of behaving vertebrates provided a wealth of ideas on progression/staging of brain function across lifespan. Behavior is unmatched as a noninvasive quantitative readout of brain function (and, one that matters).
Lifelong behavioral screen reveals an architecture of vertebrate aging | Science
Was a wonderful collaboration with @clairebedbrook.bsky.social, Libby Zhang, Scott Linderman, @brunetlab.bsky.social & @deisseroth.bsky.social
www.science.org/doi/10.1126/...
Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2
🧪 New from incoming LSI faculty Claire Bedbrook & Ravi Nath, from @brunetlab.bsky.social's lab: www.science.org/doi/10.1126/... 🧪
Ravi Nath and Claire Bedbrook stand in an aisle of shelves filled with fish tanks. Photo by Andrew Brodhead.
On today's podcast, we talk with neuroscientists Claire Bedbrook and Ravi Nath about their new study, which found that an animal's lifespan can be predicted surprisingly early by observing its behavior. @brunetlab.bsky.social @deisseroth.bsky.social
🔗 neuroscience.stanford.edu/news/why-do-...
Multi-organ transcriptomic aging atlas in killifish, with both males and females! 🐟🐟🐟
Huge congratulations to Emma, Jing, Tony and the entire team!! ✨⭐
@emkcosta.bsky.social
@jingxunchen.bsky.social
Wyss-Coray lab!
www.nature.com/articles/s43...
Online now! Costa, Chen et al. performed RNA-seq on 13 tissues, six ages in male and female African turquoise killifish. The Killifish Aging Atlas provides a comprehensive resource for aging studies. @emkcosta.bsky.social @jingxunchen.bsky.social @brunetlab.bsky.social
doi.org/10.1038/s435...
Congratulations to the entire team and a huge thank you to all collaborators! Thank you so much for the support of the Knight Initiative for Brain Resilience at Stanford for this project! 🙏
We are excited by this study because it provides the potential for 'immunotherapies' for the old brain.
Of course, a lot remains to be done, including identifying additional efficient 'immunotherapies' that can rejuvenate old brain function.
More broadly, this IL-10 variant has beneficial effects on cognitive behavior (done with Saul Villeda's lab) in old mice.
This suggests that quenching inflammation in old brains can boost cognitive function in old individuals
Importantly, this IL-10 variant decreases inflammation in both neurogenic niches in the adult brain – the subventricular zone and the dentate gyrus.
The IL-10 variant has a small beneficial effect on the production of new neurons from the subventricular zone neurogenic niche in old individuals.
We found that this engineered IL-10 variant reduces inflammation in microglia (and does not trigger strong T cell activation) in old brains.
We chose IL-10 because we noticed that the IL-10 pathway is going down with age, notably in microglia.
We infused this engineered IL-10 variant that is more targeted toward anti-inflammation into old brains and examined its impact using a variety of assays.
So could age-dependent inflammation be quenched to counter brain aging?
For this, we used an engineered cytokine (IL-10) which has anti-inflammation properties and was generated by Bobby Saxton in the Garcia lab.
We found that infusing this checkpoint inhibitor into the brain triggers massive inflammation of microglia.
This suggests that reversing T cell exhaustion actually augments inflammation in the aged brain (which is already more inflamed than the young brain), which is likely detrimental.
We wondered what would happen if we infused a checkpoint inhibitor into the aged brain to reverse this T cell exhaustion.
We used a potent checkpoint inhibitor (RIPR-PD1) engineered by Ricardo Fernandes in the Garcia lab, and we examined its effect on a key brain region – the subventricular zone.
We and others had previously observed that cytotoxic T cells strikingly accumulate in the old brain.
Characterizing T cells from aged brains, we noticed that some of them have hallmarks of memory T cells whereas others have hallmarks of exhausted T cells, such as the checkpoint protein PD1.
Brain aging is associated with cognitive decline and a dramatic increase in neurodegenerative diseases, including Alzheimer's disease.
Could 'immunotherapies' – strategies based on the immune system – counter brain aging?
Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!!
Congratulations to Paloma Navarro and the entire team!
Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab!
www.cell.com/immunity/ful...
We have posted a Research Assistant (LSRP1) position to work on aging and 'rejuvenation' using mouse models!! 🐭
careersearch.stanford.edu/jobs/life-sc...
Apply and join our awesome lab!! (please share) 😎
Interested in the mechanisms of aging and 'rejuvenation'?
Our lab at Stanford has a Research Assistant/Lab manager position open!!
Apply and join our awesome team! 😎 (please share)
careersearch.stanford.edu/jobs/life-sc...
New episode (1211), with Dr. Coleen Murphy (@ctmurphy1.bsky.social). We talk about her book, How We Age: The Science of Longevity. #Biology #Science
YouTube: youtu.be/Fy22JhtHhdU
Podcast: bit.ly/4a1fCh8
We are hiring!! Lab Assistant II position to work with the killifish! 🐟🐟🐟 This is an amazing model to study aging and 'suspended animation'
careersearch.stanford.edu/jobs/lab-ass...
Come and join our fantastic team at Stanford!! 🤩 Please share!
