Now in @cellpress.bsky.social: We profiled cerebrospinal fluid proteomes from 5,000 neurology patients by mass spectrometry — mapping protein changes across stroke, brain cancer, infections & autoimmune diseases, revealing shared and disease-specific signatures.
www.sciencedirect.com/science/arti...
MSACL moving to Montreal was a great move in hindsight.
Scientist role at Lilly developing and validating mass spectrometry based biomarkers to support clinical trials in Alzheimers Parkinsons ALS and rare brain disorders.
www.dementiaresearcher.nihr.ac.uk/job/advisor-...
Ah that’s annoying
The best and durable companies consider all main stakeholders including customers, employees and shareholders.
Looking forward to reading it.
I’m glad. A lot of successful IP-MS assays we have heavily relies on internal antibodies.
Congratulations!
Can I upgrade my 480 to Excedion?😜
I run it at 0.8 uL/min with 50C heating and the pressure is at 600 bar. I also commonly use it at 0.4uL/min, off the top of my head it is at around 350-400 bar. 1000 bar if I run it at 1.3 uL/min.
I like seeing proteomics folks picking up CLSI C64.
Recently got a TQ absolute. Will report back once we start running samples with Ionkey. We mostly run plasma and CSF samples.
Post-transcriptional regulation and post-translation modifications explains big part of the missing correlation?
This is indeed quite exciting. Very much looking forward to it.
Thyroglobulin is a famous one. To be honest, there are not many. Unlike ELISA where GMP quality labs produce kits to ensure assay maintenance, I think it’s challenging to maintain a mass spec protein biomarker in the clinic with the labs being the developer and manufacturers at the same time.
Rapizyme is pretty awesome. Highly pure, heat resistant.
Rapizyme maybe able to replace out trypsin+ProteaseMax to be honest if you want it simple.
To the last point: This the FDR discussion?🤣
