Summary of Artificial Development System Models
#DBfeature #DBreview
Engineering development: From the repressilator and toggle switch to synthetic developmental biology
by Margaret Saha et al
www.sciencedirect.com/science/arti...
Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells
Fig. 1. Early expression of TgBAC(ankrd1a:EGFP) transgene in the border zone CMs. Hearts of TgBAC(ankrd1a:EGFP);Tg(−0.8myl7:nls-DsRedExpress) (n = 4) were cryoinjured and left to recover for 6 and 15 h. White dashed line outlines the ventricle. Scale bars, 200 μm.
Fig. 6. Persistent TgBAC(ankrd1a:EGFP) expression in CMs adjacent to the residual scar. Hearts (n = 4) of TgBAC(ankrd1a:EGFP);Tg(−0.8myl7:nls-DsRedExpress) zebrafish were cryoinjured and analyzed at 30 dpci, showing different levels of scar resolution (least (A) to most (D) regenerated). The whole hearts after dissection were imaged by fluorescence microscopy (A-D). Serial sections were used for AFOG staining (bright-field images on panels А'-D′) and fluorescence imaging by confocal microscopy (А"-D″). In the indicated region of injury on panels A'-D′, collagen is stained blue, fibrin is stained orange, and CMs are stained brown. Scale bar, 100 μm.
An interesting paper from the Kojic lab shows that ankrd1a - a stress responsive gene is consistently unregulated near damaged site in the ❤️ in zebrafish. Loss of ankrd1a leads to an increase in dedifferentiating cells. Check it out here:
doi.org/10.1016/j.cd...
Reminder: PhD position in my lab is open for two more weeks.
How do germ cells use their own private transcription factors? Come help us find out.
Fully funded. Deadline May 1.
Flyer attached — please boost! 🙏
Nice way to let me know I’m not young anymore 😁
Pictures from Fanny Martinez Real and Stefan Mundlos🙏
This year, the annual symposium of my Chaire @college-de-france.fr will be on The Evolution of Developmental Mechanisms. An impressive lineup of speakers and weirds animals, including humans. Free entrance and coffee breaks. Come, have a seat, relax and enjoy the best possible basic science🤘RT🙏
Reminder! Application deadline Friday 8th May
🎉 Great success for our 2nd SFBD-SBCF science outreach day in Ivry-sur-Seine, with the support of the city!
Over a thousand children came to take part in our workshops, led by around fifty researchers from institutes in Paris and Gif-sur-Yvette! Thank you all for your enthusiasm! 🔬🧬
A fantastic day of outreach in Ivry with 43 classes, 1075 kids and 47 scientists from the @sfbd.bsky.social and @sbcf.bsky.social. Thanks: Mairie of Ivry, @drosopachea.bsky.social Maeva Eglantine and Stéphanie for organizing! And many participants @antoinezalc.bsky.social @michaelrera.bsky.social +
In this chaotic ever-changing world of ours, one constant remains over the years: Failed Microsoft updates
Proud to share this work with @kevinchalut.bsky.social and Byron Mui. Why do some injuries scar while others regenerate? Using digit tip models, we show the ECM is a key driver. HA-rich ECM promotes regeneration, and boosting it can shift healing away from fibrosis. www.science.org/doi/10.1126/...
Paris in the spring is amazing !
Preparing lunar observation seems as messy and fun as setting up a FACS
Hope the evil forces of Vega will let Orion spacecraft alone
Rocking for 2000 years 🤟🏻🤟🏻🤟🏻
Pictures of Marie Curie and some of her lab notebooks !
Not giving up my notebooks for online stuff anytime soon!
After 39years in Paris, today I discovered the National Library Museum
Care Bears also took off to the Moon!
#artemis2
This is why dried mango is the best
Doesnt do well during warm summer and chocking hazard while cycling (these are the new hidden variables 😂)
😂😂
Great on a bicycle 😂😂
Saucisson isn’t a snack. It’s an art de vivre
Waiting to see what @agathechaigne.bsky.social has to say against it
I love trader Joe but I’m getting my dried mango directly on the market
High chocking hazard! See cycling comment 😂
