AlphaFold database hits ‘next level’: the AI system now includes protein pairing The database of 200 million protein-structure predictions now includes homodimers, adding new biological relevance.

Very cool — AlphaFold database now includes homodimer protein complexes (where two of the same protein unit combine to actually build a functioning unit) www.nature.com/articles/d41...

Taking a page from Ukraine & Iran's playbooks on dealing with larger, more equipped rivals, Taiwan now investing heavily in building "China-free" drone technology benjamintseng.com/2026/03/taiw...

China woman uses AI-made man to lecture on respecting science, rejecting superstition Non-existent retired professor who ‘lectures’ on parent-child relationships gathers online support from 200,000 followers.

Use AI to talk back at your parents

www.scmp.com/news/people-...

Shot. Chaser.

There's a consequence to the two parties being captured by extreme online opinions

@gallup.com polls show record high fraction of Americans consider themselves Independent with GenZ / Millennials identifying >50% as independent

More @ news.gallup.com/poll/700499/...

I finally gave in to the old man in me 👴🏻

My IDEs are no longer in dark mode. I have seen the light (mode)

Recent studies have shown by directing CAR-T Cells at B-cells (which make the autoantibodies that cause much of autoimmune damage), you not only eliminate the autoantibodies, but potentially "reset" the immune system to a healthier state

Literally a potential cure! benjamintseng.com/2025/12/car-...

Hard to tell if this is deliberate fine tuning or a strange product of how Chinese models need to be tuned so as to NOT disagree with the stance of the CCP🇨🇳

But underscores some of the risks associated with using Chinese models

CrowdStrike Researchers Identify Hidden Vulnerabilities in AI-Coded Software CrowdStrike researchers reveal how trigger words cause DeepSeek-R1 to generate vulnerable code—exposing new AI-driven risks in software development.

Shocking but not at the same time

Chinese DeepSeek model (the 670B reasoning one) produces 50% more security vulnerabilities when a politically sensitive "trigger word" (eg Taiwan, Tibet, Uyghur) is present in the request

www.crowdstrike.com/en-us/blog/c...

The final Buffett letter includes this charming anecdote & suggestion to us all on how to live a good life

Text of the full letter: www.berkshirehathaway.com/news/nov1025...

Who’s Jobs are AI Taking Right Now? Despite all the speculation over why Amazon is laying off 14,000 workers, as of this writing, and with a few exceptions I’ll note below, I don’t personally worry a great deal about AI t…

I'm generally optimistic about AI technology (yes, even for our careers) ... with one exception, and the data is starting to prove my fears right

benjamintseng.com/2025/11/whos...

#ChemSky

Seven Lessons from My 30s Source: Nano Banana Turning 40 is a milestone that should come with a manual. It doesn’t, of course, but it does come with a decade’s worth of receipts for lessons learned the old fashioned way. As…

Turning 40 is a milestone that should come with a manual. All I got were these lessons instead -- hopefully they help (or at least amuse) you

Read all about the 7 lessons in full here: benjamintseng.com/2025/10/seve...

Lesson 7: Play stupid (status) games, win stupid prizes

Status games are everywhere (ask any parent of young kids the last time an ad or article made them feel guilty).

Recognize them and consciously decide which ones are actually worth your time and energy

Lesson 6: Good taste is overrated

In your career, good taste is an asset

In life? It’s better to have low standards. Being easy to please (ie with wine, movies, food) is a superpower for everyday contentness. It saves you time, money, and mental energy for what truly matters.

Lesson 5: Genius doesn't generalize

In an age of influencer marketing & interview podcasts, its important to remember what it takes to be brilliant at one thing comes at the expense of others

TLDR: don't ask a gymbro for relationship advice or a VC about how to help the poor

2020 was a hard year. I was unemployed w a young son & aging parents I couldn't see

But it was also the year I built a telemedicine operation 0-to-1, built AI models which made it into academic papers, and did policy work which led to new friends & opptys

Embrace the unlikely

Lesson 4: Embrace the unlikely

My 30s included my getting fired, a pandemic, 9% inflation, US political re-alignment, my being put on a legal witness stand — all things I thought were unlikely.

Prepare for what you can, but also learn to embrace the unlikely...

Lesson 3: There’s little upside in talking about politics

Modern political discourse is about tribal outrage. It leads to bad policy and bad behavior.

Disengage from the daily outrage cycle and focus on *policy*. It's boring, but that's a feature, not a bug

Knowing someone is a doctor tells you a great deal about their education, income, and views on risk & credentials.

Knowing someone is a politician tells you they're professional fundraisers and popularity contest winners, and that they're structurally surrounded by flatterers

Lesson 2: A profession gives an oddly effective read on a person

Careers shape our incentives, skills, and definitions of success/failure. While not the whole story, knowing what someone does for a living offers a surprisingly useful set of heuristics for understanding them.

Lesson 1: Don't partner with someone until you've seen them in a crisis

It’s easy to be open & giving when things are good. It's the bad times that reveal value & priorities. Before you enter a partnership (💰 or ❤), see how they handle a storm

My 30s were a wild decade of learning things about being a parent & about how the world works. As I head into the next decade, I've been reflecting on the lessons that have reshaped how I see the world.

Here are 7 of them. 🧵

How you know it's time to start thinking about selling...

Gene therapy for Huntington’s shows promising clinical trial data Huntington’s Disease is one of the classic “uncurable” neurodegenerative diseases. A genetic mutation produces a mutant form of a protein (called Huntingtin) which leads to sudden…

Gene therapy for Huntington's Disease shows 75% slowdown in progression over 36 month clinical trial!

Amazing feat — working gene therapy + targeted surgery + synthetic control arm — and for company uniQure (who's seeing a 3x stock price bump on the news)

benjamintseng.com/2025/09/gene...

Why are ultra-processed foods bad for you? Nutrition is a field that is fraught with studies that are not powered or designed well enough to make strong conclusions about what types of diets are the “best”. So it was interesting…

Why are ultra-processed foods bad for you? benjamintseng.com/2025/09/why-...

Child dies from rare measles-related complication, LA County health officials say Health officials reported the death of a Los Angeles County child from a complication of measles infection acquired during infancy.

Death from sub-acute sclerosing panencephalitis (SSPE) in a child in Los Angeles
SSPE is a rare sequel of #measles infection that appears years after the initial infection, and is uniformly fatal. So sorry for this family. As things are going on the US, we'll be seeing more of these cases.

The Surrealism of Authoritarianism Among the obvious hallmarks of authoritarianism are: Arbitrary paranoia from on high — where students singing patriotic songs on bike rides are suddenly viewed to be a threat Contradiction be…

The Surrealism of Authoritarianism -- a look at life under Xi Jinping outlines some of the hallmarks of authoritarian rule benjamintseng.com/2025/09/the-...

You are buying this shirt because you're a Swiftie

I'm buying this shirt to protest the Chinese Communist party

We are not the same 🤣

Listening to a medical informatics professor talk to a Med Student who thought he could vibe code through a data analysis & fail because he doesnt understand how the code or the data works 🤦🏻‍♂️

Vibe coding can be great: but don't use it where it matters if you can't check it