On voit Tintin et les deux Dupont et Dupond. L’un des deux Dupont dit : si Ormuze un détroit… Et l’autre Dupont finit la phrase : qui sont les deux autres ?

🤔

From NASA APOD - PanSTARRS and Planets Image Credit & Copyright: Luc Perrot (TWAN) Explanation: Near the eastern horizon before sunrise, Comet C/2025 R3 PanSTARRS is getting brighter. Readily visible in binoculars and small telescopes, the comet may be just on the verge of naked-eye visibility from dark sky sites. Though it was not quite apparent to the eye, PanSTARRS is still easy to spot in this camera image taken on April 16. In the view from a volcanic peak overlooking France's Reunion Island, planet Earth, the comet shares eastern predawn skies with naked-eye planets Mars and Mercury and fainter Neptune. Saturn is hiding behind the low cloudbank that doesn't quite hide an old crescent Moon. This is a good weekend for northern hemisphere comet watchers to try to catch PanSTARRS an hour or so before sunrise, as the comet grows brighter approaching its perihelion on April 19. On April 26 the comet makes its closest approach to our fair planet but by then will be difficult to see in the solar glare. Good views of this comet PanSTARRS in late April and early May will be from the southern hemisphere.

‪Another outstanding artistic pic of comet C/2025 R3 (PanSTARRS) captured by astrophotographer Luc Perrot on April 16 from a volcanic peak overlooking France's Reunion Island.

Featured at apod.nasa.gov/apod/ap26041...
More info on the comet at fosstodon.org/@AkaSci/1164...
#Astronomy #Comet

Le saviez-vous ?

Sophie Adenot, l'astronaute française qui se trouve actuellement dans la Station Spatiale Internationale, poste régulièrement des petites capsules vidéo où elles vulgarise de manière très pédagogique sa vie quotidienne et les phénomènes observés dans la station en micro-gravité.

This really showcases the promise of using mouse sys neuro. to understand human clinical treatments, congratulations! Still struck by the 150 s long calcium events.

Oh wow - that’s surprising and exciting for all sorts or reasons, including the development of refined interventions. Congrats all around to the team!

This work was a collaborative effort between our lab and clinical experts at UPK Basel. The parallel approach of using mouse circuit and human patient data is likely the most promising approach we have to understanding the mechanism of psychiatric treatments.

Full paper:
doi.org/10.64898/202...

In our study, if a mouse hemisphere had a seizure but no CSD, there was no increase in Fos. The plasticity only happened where the CSD traveled.
We also saw that the EEG metrics clinicians use to predict patient success correlate with CSD in our mice.

For nearly a century, we believed the therapeutic effect of ECT is the seizure. Our latest research suggests we may have been looking at the wrong event.
A thread on why cortical spreading depression (CSD) might be the driver of therapeutic benefit.
Work led by @therehugolad.bsky.social

Thank you Georg! Very happy to have worked on this.
Here is a short 🧵 on what ECT-triggered CSD looks like, and why we think it is going to help shape the future of ECT research.
(1/12)

Eventually after filtering, we saw that oscillations co-occur with CSD. We ended up combining EEG with widefield imaging and saw that the calcium signal held beautifully to the EEG. Most likely, AC-coupled patient EEG is simply blind to the CSD, and can only pick up the oscillatory response.
(6/12)

To the best of my knowledge, this is the 1st time mouse ECS is validated as a pre-clinical model of human ECS based on direct neuronal responses.
However, during the very first ECS we recorded, I completely missed the oscillations, and had a proverbial tree (i.e. a CSD) hiding the forest:
(5/12)

We started by measuring these oscillations following a single electroconvulsive stimulation (ECS) in mice and patients. They look extremely similar - one could mistake the mouse response for the human one (that actually happened when I sent the first figures draft around🙃).
(4/12)

There is nearly a century of research on the effects of ECT, and it has become clear that the "seizure" it induces does not predict therapeutic effects. In patient EEG, the immediate response to ECT are beautifully synchronous oscillations stabilizing around 1-5 Hz before abrutply ending.
(3/12)

https://pubmed.ncbi.nlm.nih.gov/11940941/

We've come a long way since the 1st ECT by Ugo Cerletti and team in 1938 (the history of ECT is worth a read btw).
To transform ECT from psychiatry’s most potent intervention into a targeted, reliable therapy, we need to fully characterize what it ECT "does" to the brain.
(2/12)

Est-ce que vous utilsez #Claude ?

Unglaublich !
« Une femme » vient d'ajouter une ligne à son palmarès en devenant l'entraîneuse d'une équipe masculine du championnat d'Allemagne de football .
Mais où trouve-t-elle toute cette énergie ?
Wikipédia vous raconte son incroyable histoire 😉 ⬇️:
fr.wikipedia.org/wiki/Wikip%C...

Quelqu’un a osé lui dire que l’Iran lui a déjà piqué l’idée depuis des semaines?

1/8. New preprint! ✨

How spontaneous is spontaneous behavior? 🧠🐭

We found that whole-brain fUSi signals predicted spontaneous behavioral transitions seconds in advance. Inhibiting one node of this transition-prone state, the medial septum, facilitated switching!

www.biorxiv.org/content/10.6...

I wrote a short mathematical companion tutorial to my notebook on discrete diffusion models. It gives an informal derivation of the connection between maximum likelihood estimation of the backward transition kernel and denoising score matching. github.com/gpeyre/Discr...

Woodpecker on the side of a tree with blue sky behind and some out of focus green leaves in front.

Not normally into bird #photography but quite pleased that I managed to get a shot of a woodpecker! Even managed to get a video of it pecking.

💡 11 avril 2026 - Forum des Sciences Cognitives cognivence.scicog.fr/forum-des-sc...

Chaque année, cet événement rassemble chercheurs, étudiants, professionnels et curieux pour découvrir et échanger autour des sciences cognitives sous un angle accessible et interactif.

Hey, I wrote a thing about AI in astrophysics
ergosphere.blog/posts/the-ma...

Our paper is out !

Enjoy it online at

doi.org/10.3390/visi...

more on

laurentperrinet.github.io/publication/...

🔬 Excited to present our latest research at the #MAIN2025 conference today!

🔗 laurentperrinet.github.io/talk/2025-12...

#DeepLearning #ComputerVision #AI #Research #NeuralNetworks #NeuroAI #OpenScience I love #Montreal

Our paper is out !

Enjoy it online at

doi.org/10.3390/visi...

more on

laurentperrinet.github.io/publication/...

Bonne journée de l'esprit critique à toutes et à tous 🐟

Il leur a quand même fallu déplacer Pluton sur l’orbite de mercure pour obtenir gain de cause. Il faut ce qu’il faut.

Depuis 2006, et le déclassement de Pluton, les américains attendaient ça.
C'est maintenant chose faite.

« Planètes », un film du CNRS en ode au vivant Avec « Planètes », son premier long-métrage de fiction, la réalisatrice Momoko Seto, ingénieure de recherche au CNRS, met en lumière la faune et la flore foisonnantes qui vivent à même le sol.

Avez-vous déjà vu le logo du CNRS au générique d’un film de fiction ? projeté au festival de Cannes en 2025 ?

C’est désormais chose faite avec "Planètes", le premier long-métrage de Momoko Seto, ingénieure de recherche au CNRS et médaille de cristal en 2021.

lejournal.cnrs.fr/articles/pla...