Spontaneous behavior is a succession of self-directed tasks Weinreb et al. reveal a hierarchy of timescales in mouse behavior, including low-level syllables and high-level behavioral states. States and syllables are encoded in different brain areas. Prefrontal...

Have you ever wondered why mice do what they do when they are free to do whatever they want? Check out our latest (and this slightly delayed thread about our recent paper, led by Caleb Weinreb and friends...) www.cell.com/neuron/fullt...

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social

We gave a worm brain control of a fly body and it walked

What did we learn? Nothing, other than deep reinforcement learning is effective

We call it the digital sphinx

www.biorxiv.org/content/10.6...

*Recruiting new group leaders*

The @lmcb-ucl.bsky.social at University College London are looking for outstanding candidates to sponsor for career development fellowships. Fellows would then be assessed for tenured positions at the end of the fellowship term.

Our lab is looking for a postdoc! We have interesting projects and cutting-edge techniques such as Neuropixels Opto, Light Beads Microscopy and more. We would be delighted to receive your application. Deadline is 25 November 2025. More info here:
www.ucl.ac.uk/cortexlab/po...

Postdoctoral Research Position University of California, Los Angeles is hiring. Apply now!

🚨 Please RT!
We’re recruiting a motivated postdoc to dissect the neurocircuits of affective pain.
Expertise in behavioral models of pain/SUDs, stereotaxy, microscopy, opto/chemogenetics, or fiber photometry encouraged.
Apply 👉 recruit.apo.ucla.edu/JPF10647

#Neuroscience #Postdoc

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!

apply.interfolio.com/174756

From nociception in aneural animals to human suffering: toward a comparative biology of pain Summary: The biology of widely shared and unusual features of human pain is informed by functional and mechanistic comparisons of nociception and pain-like aversive states across vertebrate and invert...

If evolution, comparative #neuroskyence & #PainResearch are your thing, here's a great review from Terry Walters: journals.biologists.com/jeb/article/...

One week left to apply!

Lots of exciting clinical PhD projects at Crick - including the opportunity for neurosurgeons to work with us and record electrical activity in patients with neuropixels probes. Please share widely!

We are proud to launch what we think is going to be fantastic opportunity for pain neuroscientists and clinicians to learn the foundations of pain neuroscience

New preprint out from the lab. We identified three critical windows over which sensorimotor behaviours can be shaped. Altered early experience over these windows changes somatosensory and motor outcomes for life. Tour de force experiments by Laura Andreoli. @medresfdn.bsky.social @uclnpp.bsky.social

We're looking for a senior project coordinator in Oxford - apply by friday eng.ox.ac.uk/jobs/job-det...

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future!

www.nature.com/articles/s41...

We are super excited about the first human transcranial ultrasound study from our lab which is now on BiorXiv, showing the amygdala‘s role in processing ambiguous emotions and showing TUS changed resting-state connectivity and metabolite concentrations (GABA) in the amygdala - a huge team effort! 🥳🙏🏼

Sensory responses of visual cortical neurons are not prediction errors Predictive coding is theorized to be a ubiquitous cortical process to explain sensory responses. It asserts that the brain continuously predicts sensory information and imposes those predictions on lo...

1/3) This may be a very important paper, it suggests that there are no prediction error encoding neurons in sensory areas of cortex:

www.biorxiv.org/content/10.1...

I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.

But...

🧠📈 🧪

Quote: "The community of neuroscientists is so incredible at SWC, and I wanted to come and share my work and ideas with them." Christopher Zimmerman, 2024 ENSS Speaker

Calling all neuroscience postdocs!

Come and share your work with the London neuroscience community. No CVs, publication records or recommendation letters needed.

Learn more about SWC’s Emerging Neuroscientists Seminar Series and apply by 10 July:

www.sainsburywellcome.org/web/content/...

A hypothalamus–brainstem circuit governs the prioritization of safety over essential needs - Nature Neuroscience Animals need to adapt behavior to balance survival with fulfillment of essential needs. Krauth et al. identify neurons in the lateral hypothalamus that, when activated, prioritize survival over other ...

Excited to present our study in ‪@natneuro.nature.com‬: a deep brain pathway that triggers safety-driven movement—overriding needs like finding food or social contacts. A look into how the brain weighs deep instincts. Congrats to all and first author @nkrauth.bsky.social. shorturl.at/toYFN

🧠 🍄 ⚡️🐭

Now published in @natneuro.nature.com

Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility

nature.com/articles/s4159…

A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain Although topographical maps organize many peripheral sensory systems, it remains unclear whether olfactory sensory neurons (OSNs) choose which of the ~1100 odor receptors (ORs) to express based upon t...

Maps are everywhere in the brain...and finally we've discovered one in the nose! Led by @davidhbrann.bsky.social, we uncovered the logic that specifies the positions of each of the 1,000 sensory neuron subtypes in the nose and aligns their projections to the brain.👇👃see more details below👃👇

Linking function and structure at scale with X-rays - and several times over. Massive congratulations to the team ‪@yuxinzhang.bsky.social‬, @carlesbosch.bsky.social, @apacureanu.bsky.social @esrf.fr, @crick.ac.uk and all our collaborators.

We've developed a way to remotely and precisely activate skin sensory neurons in mice as they naturally explore and navigate their environment - opening doors for studying sensation, behaviour, and pain in naturalistic settings.

Now out: shorturl.at/ry4s9

#neuroskyence #neuroscience #PainResearch

Systems Neuroscience PhD at UCL at University College London on FindAPhD.com PhD Project - Systems Neuroscience PhD at UCL at University College London, listed on FindAPhD.com

2. Systems Neuroscience PhD position, supervised jointly with Sarah Ruediger @ruedigersarah.bsky.social

This is to investigate the differential circuits involved in habitual and goal-directed behaviours.

www.findaphd.com/phds/project...

Computational Neuroscience, NeuroAI PhD at UCL at University College London on FindAPhD.com PhD Project - Computational Neuroscience, NeuroAI PhD at UCL at University College London, listed on FindAPhD.com

1. Project on Computational Neuroscience / NeuroAI PhD, supervised jointly with Caswell Barry @caswell.bsky.social

Here we want to build NeuroAI models that transform visual information to spatial navigation information.

www.findaphd.com/phds/project...

New preprint ✍️🚨

✨Ontogeny of tactile, vocal and kinship dynamics in rat pup huddling

-Huddle dynamics develop w/o kinship selectivity
-Vocal/internal-state quiets w/ huddling & kin/ touch in yng pups

tinyurl.com/y7vhkwjc

👏 @flor-bela.bsky.social @hughtakemoto.bsky.social @kinshiplab.bsky.social

Last few days to apply to come work with our team- deadline 11th April. See details below.

New preprint out! We developed a behavioural platform for the kinematic analysis of skilled whole body behaviour. Very fun collaboration with Christopher Black, @liamebrowne.bsky.social and Rob Brownstone.

Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.

www.nature.com/articles/s41...

Excited to present the latest from the lab out today in Cell www.cell.com/cell/fulltex.... See Thread! 1/8

On behalf of my BSky-less student, Lisa Wooldridge:

🐭🧠💊⚡️

"Thrilled that my PhD work is on bioRxiv! I study how central amygdala (CeA) neurons contribute to opioid effects, but how specific CeA cell types drive this process remains unclear"

🧵

www.biorxiv.org/content/10.1...

Identification of V0g propriospinal neurons and their role in locomotor control Propriospinal neurons relay sensory and motor information across the spinal cord and are critical components of the circuits coordinating body movements. Their diversity and roles in motor control are...

🥁 Elisa Toscano idenitified a new subtype of propriospinal neurons and found a role in the execution of skilled movements🤸‍♂️. Great job from Elisa and everybody involved 💪. @alesantuz.bsky.social, @lowensteined.bsky.social. Check it out and let us know what you think:
www.biorxiv.org/content/10.1...