Delighted to have contributed to this new study @nature.com on the genetics of ageing and mortality 🧬
Using a large mouse cohort, we uncover age- and sex-specific genetic effects, including trade-offs where variants are beneficial early in life but detrimental later.
Reconstructing mammalian lifespan evolution reveals strong phylogenetic effects and lifespan-associated genes
link.springer.com/article/10.1...
Happy Earth Day! 🌎 🌍 🌏
To mark this special day, we’re tuning in to Sen, the world’s first continuous 4K video livestream from space.
Sen’s cameras are hosted on our Columbus module of the ISS, with data delivered via the Airbus platform.
Watch Earth from above, just like an astronaut
📹 Sen
Comparative Oncology: Evolutionary Perspectives, Emerging Discoveries, and Analytical Advances
www.annualreviews.org/content/jour...
Multitissue, multi–time point transcriptomic atlas of aging in mice and rats
www.science.org/doi/10.1126/...
Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence
www.nature.com/articles/s43...
Insights into a long life without cancer: The case of the bowhead whale
febs.onlinelibrary.wiley.com/doi/10.1002/...
Antagonistic Pleiotropy Framework for the Discovery of Molecular Mechanisms of Aging
www.preprints.org/manuscript/2...
Great to speak at Targeting Longevity 2026 in beautiful Berlin, catch up with old friends, and meet new colleagues.
From genomes to systems biology and machine learning, we need robust, data-driven models to understand ageing and identify the most promising interventions.
Great study in the bristleworm showing that light perception can regulate lifespan.
Disrupting light sensing slows development, prolongs growth and extends lifespan by ~40%.
More evidence that aging is not just damage accumulation, but is modulated by developmental processes.
Looking forward to the Targeting Longevity conference in Berlin next week!
Excited to present and discuss the current state of ageing research, including systems biology approaches and future directions for the field.
targeting-longevity.com
A deep-learning based biomarker of systemic cellular senescence burden to predict mortality and health outcomes
www.medrxiv.org/content/10.6...
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target
www.nature.com/articles/s41...
A combination of senolytics causes neuropathology in mice 👀
Dasatinib and quercetin trigger oligodendrocyte dysfunction and white matter injury in the CNS.
Senolytics under more scrutiny?
www.nature.com/articles/s41...
There are definitely worse places to discuss frailty, ageing, and using AI to discover drugs that preserve health.
The therapeutic potential of natural killer (NK) cells to combat aging and age-related diseases
link.springer.com/article/10.1...
Had a great time visiting Coventry University! Exciting collaborations ahead 🚀
Communication breakdown: senescent cells in interorgan communication of aging
www.cell.com/trends/endoc...
Integrative Proteomic and Metabolomic Signatures of Accelerated PhenoAge in the UK Biobank
www.medrxiv.org/content/10.6...
Excited to share our new preprint on multi-omics signatures of accelerated PhenoAge.
By integrating plasma proteomics and metabolomics, we identified pathways associated with faster aging, including immune-inflammatory activity.
www.medrxiv.org/content/10.6...
For 20+ years the Human Ageing Genomic Resources (HAGR) have supported ageing research worldwide (200k+ users/year, 1,000+ citations).
After losing UK government funding, we’ve launched a fundraiser to keep HAGR online. Please support or share!
www.justgiving.com/page/human-a...
The Human Ageing Genomic Resources are vital open-source databases on longevity genes and drugs, and animal lifespans. It would be a loss to the field if they go offline due to funding cuts.
See @jpsenescence.bsky.social’s post here for more details and how to support:
