Representative 3D reconstructions of brain ventricles from control and high-dose AAV2/5-injected pups at 2, 5, and 7 days post-injection (P2.5, P5.5, P7.5). Quantification of total ventricular volume across time points. (n = 3 per condition).

📃Preprint alert @biorxivpreprint.bsky.social. Does your 2026 involve ICV injection of AAVs 🧠? If so, this study led by Luke is for you. "Adeno-associated viruses (AAVs) induce dose-dependent neonatal ventriculomegaly following intracerebroventricular administration" www.biorxiv.org/content/10.6...

Representative coronal sections at the level of the posterior anterior commissure (pAC; dashed outline) showing lateral ventricle morphology in P7.5 brains following P0.5 ICV injections.

Dose is key🗝️. Higher doses of AAV (1uL of 4 x 10^12 GC/mL) consistently induced ventriculomegaly and permissive tropism in neonates, while moderate doses (1uL of 1 x 10^12 GC/mL) did not. Study led by Luke Liu, with true collaborative effort with Ania Noguera, Ryan Humphries, and Blake Zhou.

Fame lab!

Such a joy to celebrate with this group! Happy holidays from our lab to yours! 🧠☃️

Blake Zhou Sunday, 11/16, 8am-12pm. Presentation Number: PSTR053.24/ A22 Location/Room: A22 SDCC Halls B-H Arjun Rajan Sunday, 11/16, 1pm-5pm. Presentation Number: PSTR102.04/A40 Location/Room: A40 SDCC Halls B-H Luke Liu + Ryann Fame Tuesday 11/18, 1pm-3:45pm. Session Number: Nanosymposium NANO040 Session Title: Choroid Plexus and CSF Biology Location/Room: SDCC Rm 24A Nano040.04; Nano040

Will you be at @sfn.org #SfN25? Yes? Us too! Come see the Fame lab!

Third Annual Dish Dish Dish to enjoy each other's company and celebrate a love of science! 📡 🗣️ 🍽️

Today, we celebrate Ania Noguera's time in the lab. On her last day with us, we are so excited about her transition to @ucberkeleyofficial.bsky.social - but will miss her expertise here! 🧠

Stepping out of the lab to enjoy some artistic pursuits!

Congratulations Natasha!

Congratulations Theanne!

Molecular Hallmarks of Hydrocephalus @ScienceTranslational Medicine is out today. Grateful to work under leadership of Andy Hale, Ryann Fame, & Kris Kahle with other top-notch collaborators including @labfame.bsky.social members Arjun Rajan and Blake Zhou! www.science.org/doi/10.1126/...

A The major components of the CSF system include CSF, choroid plexus, and circumventricular organs. These systems change their properties across time of day, including those listed below each component. B Multiple inputs affect the CSF system across time of day.

How does the brain 🧠 change around the clock 🕰️? Can this inform treatments?

Learn more in a new review from the lab 'Harnessing the #circadian nature of the choroid plexus and cerebrospinal fluid' ➡️ npj Biological Timing & Sleep | #Nature @natureportfolio.nature.com
www.nature.com/articles/s44...

It's World Bee Day! 🌎🐝 Here's a happy one from my back yard recently!

Join us to discuss "Unwritten Rules".

🧵1/N New study published in @jama.com on re-emergence of vaccine-eliminated infectious diseases under declining vaccination in the US. We model long-term risk and conditions for return to endemicity for measles, rubella, polio, & diphtheria. Collab w/ @Mathewkiang.com jamanetwork.com/journals/jam...

If you study #Devbiol of hearing, smell, or taste - this faculty job at at @stanfordohns.bsky.social could be for you! 🫵👇

You can learn the economic impact of your district's federal research funding here (and get a nice infographic to send to your representative). www.faseb.org/science-poli...

After 3,000 years of science, the embryo is very different | Aeon Essays For 3,000 years, humans have struggled to understand the embryo. Now there is a revolution underway

Side-hustle activated. Stoked to have this popular science piece out in Aeon Magazine:

aeon.co/essays/after...

Research: Why Passionate Men Succeed, Even When They’re Mediocre By identifying and developing promising employees early, high-potential programs aim to level the playing field and increase the representation of women in senior roles. But new research reveals an un...

"When passion is expressed by men, it’s often seen as a promising indicator of diligence and leadership capacity. Yet when women display the same passion, they face a different reaction — one that deems their passionate expressions as inappropriate."

Join our next #EinblickeBiozentrum on December 17!

Science’s ‘Dance Your Ph.D.’ contest is open again! This year’s competition has a special category on artificial intelligence research or quantum science—no Ph.D. needed

Can you explain your doctoral research through interpretive dance?

The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: scim.ag/3BcKi0e

We are honored to be hosting Dev Bio Happy Hour today! Check out this amazing poster by Blake with intellectual contributions from Arjun and Sophia! 🌊🧠

Photo of Kara McKinley

Transitions in development– an interview with Kara McKinley

Here, @karalmckinley.bsky.social talks about her transition to becoming a PI, her insights on navigating the tenure-track market in biology and her dedication to promoting gender diversity within academia
https://doi.org/10.1242/dev.204456

“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.”
www.researchamerica.org/2023-oped-us...

A starter pack! Some of my favorite women in neuroscience (sorry if I forgot you, I will add!)

go.bsky.app/SCFmKoC