Protein import-driven mitochondrial hyperactivation dictates angiogenesis independently of HIF-1α www.biorxiv.org/content/10.64898/2026.04...

Structural Basis of Mitochondrial Transcription Regulation via Interactions of PolRMT and TFAM with Upstream Promoter DNA www.biorxiv.org/content/10.64898/2026.04...

SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth - Nature Metabolism SLC6A6 localizes to the inner mitochondrial membrane and mediates mitochondrial taurine import, which sustains mitochondrial tRNA modifications and cell growth.

SLC6A6 mediates taurin import to sustain mitochondrial tRNA modifications.
www.nature.com/articles/s42...

MitoAtlas: a Domain-Resolved Spatial Map of the Human Mitochondrial Proteome www.biorxiv.org/content/10.6...

Mechanisms of human mitochondrial leaderless mRNA translation initiation.

www.nature.com/articles/s41...

U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs Garcia et al. identify a non-canonical function of the splicing factor U2AF1 in translation and localization of nuclear-encoded mitochondrial RNAs. An oncogenic missense mutation leads to pervasive ch...

U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs.

www.cell.com/molecular-ce...

Pearling drives mitochondrial DNA nucleoid distribution The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...

APEX-seq maps transcriptome-wide subcellular RNA localization in living cells Nature Protocols - This Protocol describes the transcriptome-wide labeling of RNAs in a particular subcellular compartment using proximity biotinylation by localized APEX2 enzyme and subsequent...

Excited to share our @natprot.nature.com paper on using RNA proximity labeling to map subcellular RNA transcriptomes. We’ve been working in this area for a while and wanted to create a resource paper to guide the uninitiated reader. rdcu.be/fblvI

Rab12 is a regulator of mitophagy and mitochondrial homeostasis www.biorxiv.org/content/10.64898/2026.03...

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility www.biorxiv.org/content/10.64898/2026.03...

A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP

www.nature.com/articles/s41...

Mitochondrial lactate venting limits oxidative stress The main function of mitochondria is to generate ATP by oxidizing pyruvate to CO2. Rauseo et al. show that matrix pyruvate is also converted to lactate, which is released to the cytosol via the MPC to modulate ROS production. Hypoxia increased ROS and boosted the release of lactate by mitochondria.

Online now: Mitochondrial lactate venting limits oxidative stress

Proximity labelling of the BAK macropore uncovers a new role for SLC35A4-MP in mitochondrial dynamics

www.biorxiv.org/content/10.6...

Mitochondrial inner membrane interactors of Aurora kinase A/AURKA and PHB2 shape organelle metabolic heterogeneity. www.biorxiv.org/content/10.64898/2026.03...

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress Cryo–electron tomography reveals how mitochondria reorganize their translation and folding systems under proteostatic stress.

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress.

www.science.org/doi/10.1126/...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1
www.nature.com/articles/s41...

Metabolic stress reveals widespread accumulation of cap-unmethylated RNAs www.biorxiv.org/content/10.64898/2026.02...

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA

www.science.org/doi/10.1126/...

co-first with: @andschwarz.bsky.social

with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more

🧵 0/6
#MolBio 🧪

Eukaryogenesis in light of an expanded catalogue of Asgard genomes. a, Simplified, scaled timeline spanning from before the Last Asgard archaea Common Ancestor (LAsCA) to today. Thin bands mark predicted time ranges of relevant events (for example, GOE), thicker bands represent processes (for example, eukaryogenesis), and brackets indicate the period shown in b. The timeline further highlights milestones, including potential early eukaryotic fossils60 and the modern-day co-occurrence of Heimdallarchaeia and Alphaproteobacteria observed in this study (interaction likely originated earlier).

Fig. 1 | Expanded genomic diversity of Asgard archaea. a, Maximum-likelihood phylogeny based on 47 non-ribosomal markers (NM47)using the WAG + C10 + R4 model with 100 nonparametric bootstrap pseudoreplicates, including 869 Asgardarchaeota MAGs and 309 outgroup genomes. The blue branches (lower right) indicate the new Asgardarchaeota classes, Ranarchaeia, and the recently proposed Asgardarchaeia4. The concentric rings denote (in to out): the predicted genome size, metabolic guilds based on Pfam clustering, sampling locations, and black stars on the outside mark MAGs added by this study. Asgard, Asgardarchaeia; Atabey, Atabeyarchaeia; Baldr, Baldrarchaeia; Frey/Jord, Frey/Jordarchaeia; Gerd, Gerdarchaeales; Heimdall, Heimdallarchaeaceae; Hel, Helarchaeales; Hermod, Hermodarchaeia; Hod, Hodarchaeales; Kari, Kariarchaeaceae; Loki, Lokiarchaeales; Njord, Njordarchaeales; Odin, Odinarchaeia; Ran, Ranarchaeia; Sif, Sifarchaeia; Thor, Thorarchaeia; Wukong, Wukongarchaeia. b, SR4-recoded phylogeny of the same genome set inferred with the model GTR + C60 + G and 100 nonparametric bootstrap pseudoreplicates (Methods). This updated catalogue constitutes a large increase in the medium- to high-quality publicly available genomes (completeness >50% and contamination and redundancy <10%) with 65.3% from the Guaymas Basin and 34.7% from the Bohai Sea. The encircled numbers represent MAGS added by this study. The scale bars in bothsubpanels represent the average number of substitutions per site.Map created in BioRender; Appler, K. https://biorender.com/147ieoc(2025).

Our work is published today: ‘Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor’. This was a huge effort lead by @katyappler.bsky.social. Extremely grateful to have been a part of this amazing project! 😊🦠🧬

Links: www.nature.com/articles/s41...
www.nature.com/articles/s41...

Cytoplasmic mRNA granules regulate cell fate decisions during PINK1/Parkin mitophagy www.biorxiv.org/content/10.64898/2026.02...

Mechanisms and disease relevance of mitochondrial translation in humans Nature Reviews Molecular Cell Biology, Published online: 13 February 2026; doi:10.1038/s41580-026-00948-2This Review discusses new insights into the intricate regulation of mitochondrial protein synthesis, the pathological consequences of its dysfunction in cancer and immunity, and the complexity of therapeutic targeting of mitochondrial translation.

New Online! Mechanisms and disease relevance of mitochondrial translation in humans

Organelle communication networks rewire to support lipid metabolism during neuronal differentiation www.biorxiv.org/content/10.64898/2026.02...

Graphical abstract

Researchers identify brain neurons responsible for building endurance after exercise #inmice. spkl.io/63322AtDPj

J. Nicholas Betley & colleagues
@cp-neuron.bsky.social

Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵

Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, ...

🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...

Integrative modelling reveals the structure of the human Mic60-Mic19 subcomplex and its role as a diffusion barrier in mitochondria.

www.biorxiv.org/content/10.6...

ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination

www.nature.com/articles/s41...

Schwarz lab @bostonchildrens.bsky.social identify a mechanism coupling mitochondrial movement to energy demand. When energy levels are low, the energy-sensing kinase AMPK phosphorylates the motor/adaptor protein TRAK1, arresting #mitochondria via the #actin #cytoskeleton. rupress.org/jcb/article/...

5' UTR length regulates alternative N-terminal protein isoform production in health and disease www.biorxiv.org/content/10.64898/2026.01...

We then used qExM to measure the abundance of mitochondrial respiratory chain complexes in situ!

We measured the abundances for Complex I, III, and IV.

How they differ in absolute abundances in metabolically distinct subpopulations

And even how T-cell activation changes supercomplex density