Post-replicative chromatin accessibility predicts cell fate change Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...

DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!

@emefece.bsky.social @billiedelpino.bsky.social

How DNA secondary structures drive replication fork instability DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

Excited to share our review where we propose models for how DNA secondary structures destabilise the replication fork and lead to ssDNA gaps — it’s comprehensive but genuinely a thought-provoking piece. Hope it’s useful to the community.

@costerlab.bsky.social

www.sciencedirect.com/science/arti...

Our review is out! A lot of hard work but completely worth it, especially with the best colleagues (and friends)! Hope you enjoy reading it

Transparent peer review to be extended to all of Nature’s research papers From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science

https://go.nature.com/4kIRR01

New lab member joining is a great excuse to eat out and take a new lab photo 🎉🍜📷

Messing around with AI generated images of our selfies. Is that included in lab work as a team building exercise?

#ChatGPT #AI #Academia

Caught pouting while discussing lab organization

A hanging jar with prosecco Friday contributions written on it

Stumbled upon this at work. Whoever came up with this is amazing!

@icr.ac.uk

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

📷 New lab photos 😎
Still undecided as to which one is better... But we all look so happy 😏

First day of summer @icr.ac.uk and we're treating ourselves to working in the sun and eating Gelato!

When you've been in the cell culture hood all day and finally get to take off your gloves:

I can't remember where I originally found this, but it makes me giggle every time I see it

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Problem choice and decision trees in science and engineering Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for eva...

Reading this great commentary from Michael Fischbach while trying to come up with ideas for projects! Highly recommend to new PhDs, Postdocs or PIs

www.cell.com/cell/fulltex...

😳😳😳

Excited to have joined Gideon's lab at ICR, London! Looking forward to doing great science, making new friends and also the delicious lab lunches 🍲

Graceful Dino is my favourite, but a shout out to the Jurassican pun too! I'll be using that pun in the future

The 90/10 rule of scientific discovery: 90% of your results come from 10% of your explorations, but it's not possible to know in advance what specific explorations those will be.

Exciting news!🌟 Together with Alexander van Oudenaarden, @jervdberg.bsky.social and @lleonie.bsky.social, we’ve been awarded a €2M NNF Synergy grant. We're thrilled to collaborate🤝 and to develop cutting-edge single-cell and single-molecule methods for replication and chromatin research! 🚀

Check out our recent work uncovering an unexpected role of the replicative helicase CMG in influencing cell fate decisions in vivo! We also show that it promotes differential expression of the highly conserved cell death gene egl-1 in cells fated to die!

Making cell fate decisions during development - CDB researchers and collaborators gain new insight Aditya Sethi, one of the co-authors of a paper just published in Nature Comms, explains how it offers new insights into how different cell types are generated during animal development, which in futur...

Check out the press release I wrote about our latest work on cell fate decisions in vivo! Our study has revealed that the highly conserved replicative helicase CMG promotes apoptotic fate & others such as neuronal or glial cell fate!

www.ucl.ac.uk/biosciences/...

@ucl-cdb.bsky.social

We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them.

Read more: nanoporetech.com/news/oxford-...

Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution.
www.nature.com/articles/d41...