Kewin Siah on X: "🔥 study: Insulin-like peptide 5 (INSL5) surges in response to rectal bile acids, linked to urge to defecate & diarrhea severity in bile acid diarrhea (BAD) patients. Elevated in BAD & subset of #IBS-D; predicts better ondansetron response. #Gitwitter https://t.co/CPBztSp6Wv https://t.co/Gysi9uYqrv" / X 🔥 study: Insulin-like peptide 5 (INSL5) surges in response to rectal bile acids, linked to urge to defecate & diarrhea severity in bile acid diarrhea (BAD) patients. Elevated in BAD & subset of #IBS-D; predicts better ondansetron response. #Gitwitter https://t.co/CPBztSp6Wv https://t.co/Gysi9uYqrv

x.com/KewinSiah/st...

Re-sharing on here as I don't have X - many thanks for sharing Prof Siah!

Please share across to Gastroenterology groups: our paper identifying gut hormone INSL5 having involvement in bile acid diarrhoea and ibs-d.

Discovery of role of gut hormone in chronic diarrhoea could aid development of new tests and treatments High levels of a hormone found in cells in the gut could underlie many cases of chronic diarrhoea and help explain up to 40% of cases of patients with

Interview on our published paper last week describing how an identified gut hormone is involved in symptoms of patients with chronic diarrhoea:

www.cam.ac.uk/research/new...

And here is the paper on INSL5. LC-MS/MS analysis generated similar concentration data compared to an ELISA. The peptide circulates at 100's of pg/mL in disease state, and almost undetectable in control individuals.

Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea Background Insulin-like peptide 5 (INSL5) is an enteroendocrine hormone expressed in distal colonic ‘L cells’. Bile acid receptor agonists are known to stimulate INSL5 secretion in primary cell cultur...

My project from my PhD has been published in Gut BMJ today!
The paper highlights an understudied gut hormone INSL5 has a role in chronic diarrhoea, in particular bile acid diarrhoea and a subset of patients with IBS.
@richard-kay.bsky.social
@ims-mrl.bsky.social
gut.bmj.com/content/earl...

Supervised Learning in Healthcare - Dr Chris Bannon YouTube video by Accelerate Science

My interview has been published!
Check it out below where I chat about use of AI and machine learning in healthcare research, and how I use it in my research
www.youtube.com/watch?v=NqKd...

@ims-mrl.bsky.social
@richard-kay.bsky.social
@acceleratescience.bsky.social

Being filmed for an interview talking about using AI in clinical research! @acceleratescience.bsky.social @catherinebreslin.bsky.social

Another accelerate course - another tote bag swag.
The best courses for learning AI and the best freebies around.

Just posted with the #peptidomics tag and there have only been three... Including this one!

We definitely need a Peptidomics list - us peptide MS scientists need to get the field more exposure!!

Please can I be added thanks!

Please can I be added to the list. Thanks!

Presenting my work on the need for explainable AI models in medicine yesterday at the AI for science summit!

Next up at today’s AI for Science summit is Dr Chris Bannon talking about the importance of explainable AI in medicine