Thrilled to see this out. What started out as a chat several years back with @drfejzo.bsky.social about leveraging publicly available data on hyperemesis gravidarum GWAS turned into a wonderful collaboration with April Shu, @mvaudel.bsky.social, @xwww.bsky.social and many others!
rdcu.be/fdl9k
Thank you! And yes, much more complicated than presented in the slide, and I was thinking of your work here. Can you send the full link / ref, the above is broken.
Delighted to share our latest research from the 23andMe Research Team, just published in @nature.com !
We looked at data from >27,000 participants to uncover how human genetics influences weight loss efficacy and side effects of GLP-1 medications like semaglutide. A short thread 🧵👇
Thanks Charles! Not this time but I will try to grab a recording next time I present.
i've been developing a whole cinematic universe around the missing heritability illustration characters
Some slides from a recent talk on missing heritability.
www.dropbox.com/scl/fi/kvogj...
Thanks! Yeah I'm sort of feeling out what parameters people need to update for their situation and then will add those as options.
With 10% success rates, a 5 post-doc lab is essentially impossible. A 4 post-doc lab is possible only by submitting 2 proposals for every cycle for multiple years or by submitting 1 for every cycle forever.
Some takeaways: With 20% success rates, a moderately sized lab (5 post-docs) is possible with minimal but consistent grant writing (~2hrs/week):
A little widget to play around with the various inputs and outputs that go into soft money research lab finances on a 10-year outlook.
sashagusev.github.io/PISim/
Unfortunately the journals do not make this available. I've been thinking about scraping this out of the open review reports, but LLMs are still not great at extracting from pdfs quickly/cheaply.
bsky.app/profile/did:...
I will die on the hill that the y-axis is appropriate: we actually care about the relative change here and want easily readable values
Scraped from the individual publications:
bsky.app/profile/did:...
bsky.app/profile/did:...
bsky.app/profile/did:...
Here's a little widget to play with the data across journals (as well as download the raw CSVs).
sashagusev.github.io/Genetics_Pub...
Claude scraped, will upload tonight
seems unusual
Monthly median Received to Accepted time (days) at Nature Genetics
*long whistle*
A little jukebox that plays the top hits from a desired country and year (ordered by the most distinct hits for that country).
sashagusev.github.io/world_music/
Asked the AI to make a fun slide about potential de-skilling from AI use. Need to specify more clearly what I mean by "fun".
A week ago @terzake.bsky.social gave a platform to Nathan Cofnas. At some point, Cofnas said: "The people who do know, the experts, are not the ones calling me a racist pseudoscientist." He received no critical questions about this statement. /1 www.vrt.be/vrtnws/nl/20...
hah, poor grant databases are a global problem!
I build a feed for european grant funding that's updated daily and (IMO) far more transparent then the official EU fundign website: michelnivard.github.io/eu-grants-fe... (inspired by the NIH equivalent @sashagusevposts.bsky.social build yesterday)
A line graph of the fraction of multiyear funding for R01 grants. The line for FY2025 increased in the last third of the year and the level in FY2026 is already high. Very few multiyear R01 awards were made in FY2024.
Here are the results limited to R01 grants.
Multiyear funded R01s were quite rare, but the number (and amount of funding) increased starting in mid-May 2025. The level in FY2026 is starting at this high level.
3/5
Here's a (daily updated) NIH grant listing that doesn't suck:
sashagusev.github.io/nih-grants-f...
The older data is much less granular but the success rates were clearly higher:
drugmonkey.wordpress.com/2025/07/30/f...
You must be so fun at parties