Engineered Microbes Pull Critical Minerals from Mining Waste Biomining uses engineered microbes to harvest critical minerals

Meet the Microbes That Munch Mountains of Mining Waste
Biomining uses engineered microbes to harvest critical minerals

🌏🧪😡👎

Didn't realize SCoV2 spike protein interacts with so many cell-surface receptors. Interesting that it appears to requires ACE2 for cell entry, but binds better to CNTN1.

www.biorxiv.org/content/10.6...

"survival of the fittest" != "objectively best organisms survive" the same way that "if your discoveries were worth something, they’d be funded by the market" doesn't make any fucking sense...

A question for biologists: we often talk about evolutionary novelty. What does “novelty” mean for you? What’s your favorite definition if any? Or just a rule of thumb for what is and isn’t novel.

AI Reality Check: Is the Economy About to Collapse?

“Take AI seriously, but not everything that’s written about it”

open.spotify.com/episode/6PN2...

#Caturday

Harnessing microalgae for the biosynthesis of molecular crystals - Nature Biotechnology Crystalline materials for optical applications are synthesized in living dinoflagellates.

Protein crystals next?!?

www.nature.com/articles/s41...

Scientists have seen Asgard archaea crawling for the first time. When it comes to the origin of eukaryotes, this is like seeing a feathered dinosaur in the wild. (Video courtesy of Philipp Ralder)

Role Models | No Mercy / No Malice “Society grows great when old men plant trees whose shade they’ll never sit under.” There’s an inverse to that wisdom. Great societies decline when old men chop down forests meant to provide shade and...

www.profgalloway.com/role-models/

The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...

What a breakthrough! Such a puzzle for 30 years, this is real progress!

I wonder how general this mechanism of repression is for other systems where highly-selective expression is needed.

www.biorxiv.org/content/10.6...

🐣

Simons Postdoctoral Fellowships in Plant Biology Simons Postdoctoral Fellowships in Plant Biology on Simons Foundation

Great new postdoc fellowship for foundational plant research.
If you’re into genetics and genomics of plant reproductive evolution or adaptive convergence (incl in the cool and charismatic nightshades!) I’d be happy to talk about possible projects!
www.simonsfoundation.org/grant/simons...

Thrilled to announce our new preprint, “Protein Hunter: Exploiting Structure Hallucination within Diffusion for Protein Design,” in collaboration with @Griffin, @GBhardwaj8 and @sokrypton.org

🧬Code and notebooks will be released by the end of this week.
🎧Golden- Kpop Demon Hunters

Engineered geminivirus replicons enable rapid in planta directed evolution Directed evolution can rapidly generate genetic variants with new and enhanced properties, yet efficient platforms for performing such evolution directly in plant cells have been lacking. We developed...

Out First Release in @science.org this week:
The development of a directed evolution strategy with proof of concept in plant immune protein engineering.

www.science.org/doi/10.1126/...

uNaMeRiCaN!!

Yesterday the president demanded that evidence about Covid vaccines be shown to the public. Today @apoorvanyt.bsky.social & I run through some of the studies made public over the past 4+ years that show that the vaccines work. Gift link: nyti.ms/46k17Tq

Use this magic bullet to shoot yourself in the foot OR: Borg vibes

I feel this open.substack.com/pub/experime...

😀

Interested in doing a postdoc at DFCI/Harvard on computationally designing and experimentally characterizing mini-protein binders for biomedical applications? Eric Fischer and I are looking for someone to work in our groups starting asap! Email me or my admin with a CV to apply!

Introducing the 1,000 Flower Collection 🧬🌹

I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.

Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)

The planktonic microbiome of the Great Barrier Reef Large genome databases have markedly improved our understanding of marine microorganisms. Although these resources have focused on prokaryotes, genomes from many dominant marine lineages, such as Pela...

Very excited to present the Great Barrier Reef Microbial Genomes Database (GBR-MGD), a comprehensive DB of 1000s of high-quality prokaryote, virus, plasmid, and chromosome-level eukaryote MAGs using Nanopore long reads. Subthreads incoming. Please share widely. 🙂

www.biorxiv.org/content/10.1...

Junior/Assistant/Associate/Full Specialist Positions Available University of California, San Francisco is hiring. Apply now!

We are looking to hire (yes, even in this economy!) a jr. specialist to train in protein prep/structural biology related to our AVOID-ome work as part of openadmet.org.

A great position for someone who is looking to be a tech for a few years before grad or med school.

aprecruit.ucsf.edu/JPF05424

#AStarIsBorn

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Thanks for the meme-ories!

Very cool application for protein design imo

Definitely one of my favorite things to learn recently: sweet proteins!
And that companies like Oobli and Amai already exist