Gut phage Acrs
Type II CRISPR-Cas systems dominate human gut w/diverse phage Acrs targeting these systems. Widespread family, GutAcraca, adopts similar structures to inhibit Cas9 & regulate its own expression, highlighting phage adaptation to gut ecology
www.cell.com/cell-host-mi...
Our lab is excited to share unpublished research on phage defense at the upcoming 2026 Symposium on the Immune System of Bacteria!
Today is the last day for abstract submissions: sisb2026.rockefeller.edu
Thank you to Marraffini @naamaaviram.bsky.social Seed @jbdsf.bsky.social labs for organizing!
(also, you are fast!)
thank you!
CBASS limits bacteriophage production while maintaining cell viability in Pseudomonas aeruginosa www.biorxiv.org/content/10.64898/2026.02...
Woah love it! What a fun time
Phage Phriends PhD
Abstract submission is now OPEN for the 2026 Symposium on the Immune System of Bacteria!
sisb2026.rockefeller.edu
🗓 May 5–7, 2026
📍 Rockefeller University, New York City
⏰ Abstract deadline: March 16, 2026
Attendance will be capped, be sure to register early and secure your spot.
See you in NYC!
Abstract submission is open for the SISB2026 meeting, aka Phage Defense. sisb2026.rockefeller.edu/abstract-sub...
The deadline is March 16.
Wow!
The short answer is that this doesn't matter to us. After transposition, the phage lysate is taken for selection and the bacteria expressing transposase are discarded. The bacteria certainly get transposed but we are collecting just plaque forming units
Especially this one :)
Phages are full of genes of unknown function that are likely adaptive in specific conditions.
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
Congrats Jorg!
Check this out for the 2026 SISB (phage defense) meeting in NYC. Mark your calendar! (and note the Zoom option, if needed)
sisb2026.rockefeller.edu
Our Department of Microbiology & Immunology at UCSF is running a faculty search this year for a new Assistant Professor! Please see the ad below for details. Searching for a great colleague, mentor, and scientist!
aprecruit.ucsf.edu/JPF05807
Don’t miss the inaugural Conference on Bacteriophages: Biology, Dynamics, and Therapeutics, October 12–14, 2025, in Washington, DC. A 2.5-day program of invited talks, symposia, workshops, and abstracts will highlight the latest advances. For more info: bit.ly/3JUKLYL
Interested in phage defenses that natively block lytic phage used in therapies?
Or do you want to figure out if a phage has a modified genome?
Meet the END-nucleases, an enzyme family that can broadly restrict phages with many diverse modifications. From talented post-doc Wearn-Xin Yee!
New to Bluesky and Science here. Are things more positive?
Thank you for moving it over here! Not yet up and running on bsky but learning :)