The UKB-PPP consortium should receive the first tranche of ~100k samples this autumn and subsequent tranches throughout 2026. Data releases to all approved UKB researchers will begin next year.

*Alden Scientific, Amgen/deCODE genetics, AstraZeneca, Bristol Myers Squibb, Calico Life Sciences, Genentech, GSK, Isomorphic Labs, Johnson & Johnson, Merck Group, Novo Nordisk, Pfizer, Regeneron and Takeda.

I'm deeply grateful to the hundreds of collaborators working across fourteen biopharmaceutical companies*, two technology vendors, and one remarkable biobank for making this possible.

This initiative again underpins the transformative value of public-private partnerships for drug development and healthcare and reemphasizes the quiet 'revolution' happening in the field of proteomics.

This will allow us to build foundational AI models for biological discovery, study biomarkers that change over time in response to changes in health states, identify surrogate blood biomarkers for MRI endpoints, and - ultimately - develop better medicines & diagnostics.

We will begin by profiling 300k samples, comprising approximately 250k samples collected at baseline visits and 50k samples taken at various follow-up assessments. We aim to incorporate an additional 250k baseline samples and 50k repeat samples pending additional funding.

Launch of world’s most significant protein study set to usher in new understanding for medicine

I'm delighted to announce that the Pharma Proteomics Project will commence full-scale proteomic profiling of the UK Biobank in 2025. We have selected the Olink Proteomics Explore HT platform and Ultima Genomics UG 100 sequencers for this unprecedented study.

www.ukbiobank.ac.uk/learn-more-a...

Association of polygenic scores for neuropsychiatric traits with self-reported professions based on analysis of 420k individuals from UK Biobank and Million Veteran Program. Look at the 'arts & design' category. Artistic talent comes at a cost--a piece of your mind :)

Active-reset protein sensors enable continuous in vivo monitoring of inflammation Continuous measurement of proteins in vivo is important for real-time disease management and prevention. Implantable sensors for monitoring small molecules such as glucose have been available for more...

Could be combined in the future with a continuous sensor (implant) for real-time detection of proteins driving inflammation in high-risk individuals
www.science.org/doi/10.1126/...
@science.org

Possibly, but Alamar is low-plex by design (n~250) & captures many low-abundance proteins - not necessarily the most widely studied. Mike’s comment & Jochen’s review offer important perspectives; abundance levels seem to influence confidence in cross-platform detection (higher = more confidence).

The Circulating Proteome─Technological Developments, Current Challenges, and Future Trends Recent improvements in proteomics technologies have fundamentally altered our capacities to characterize human biology. There is an ever-growing interest in using these novel methods for studying the ...

Here we tried to provide some objective views to the reoccurring discussion:

pubs.acs.org/doi/10.1021/...

The key is to understand the biases and factors causing the differences in the data. Those can include and do go beyond the antibodies.

Yes, “good” is relative to what’s been reported before. It’s the median correlation across 217 commonly measured proteins, with a wide range overall. More documentation of the antibodies used +/ epitopes bound could partially address the problem, but might be impractical to implement.

We’ve found Olink & Alamar to correlate quite well (~60%) overall. Maybe unsurprising, since both are antibody-based.

Lack of correlation b/w SomaScan & others might reveal interesting facets of the aptamer tech (protein folding, PTMs, etc) but 100% agree that infighting is bad for the field.

Loved participating in the ‘Advancing Multi-Omics to the Clinic’ meeting in beautiful Sydney this week.

Fascinating talks from several KOLs (see photos for Ruedi Aebersold’s revised Central Dogma of Biology) & lots of encouraging interplay between mass spectrometry and affinity-based proteomics.