🕛🕔🕗 Heads up! Fragile Nucleosome Seminar is at a special time this week: 2pm US West / 5pm US East / 10pm UK / 6am Tokyo / 7am Melbourne
We'll have outstanding talks on chromatin from Shabih Shakeel and @kazu-maeshima.bsky.social !!!
register here: us06web.zoom.us/webinar/regi...
Nature Communications banner with title of latest paper from the Yates, Oliver, and Rass groups at the Genome Damage and Stability Centre, University of Sussex: "Break-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32".
An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org!
www.nature.com/articles/s41...
We show that the E3 ubiquitin ligase DTX2 creates a dual hybrid ADP-ribosyl-ubiquitin mark (ADPr-Ub) at DNA damage sites, driving the recruitment of RNF114, RNF138, and RNF166 proteins independently of HPF1.
journals.plos.org/plosbiology/...
Excited to announce: the EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research: Abstract deadline: 17 May meetings.embo.org/event/26-dna... Join us!
Most genetic interaction studies measure gene relationships in one condition, but environment can reshape which genes depend on each other.
Today in Molecular Cell, Luke Gilbert & team deliver the first systematic, multi-condition map of genetic rewiring in human cells.
Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...
A group of about 30 people pose together in a bright office space.
Today, we’re launching a new company, ALTx Therapeutics. Founded by Simon Boulton, the company will develop the first precision therapies targeting ALT cancers, in partnership with Slingshot Therapeutics Limited and @crhorizons.bsky.social.
Find out more ➡️ www.crick.ac.uk/news/2026-02...
A 1-day Melbourne workshop on Gene Editing in Blood and Immune Cells. February 20, register at editblood.com
2/Led by @hildapickett.bsky.social, with co-investigators @genomestability.bsky.social, @lisannes.bsky.social, Jacob Lewis, @yuhenglau.bsky.social, Sarah Henrikus, & the Cesare Lab, this project brings together expertise in telomere biology, DNA repair, biochemistry, drug discovery, & cell biology.
1/Delighted to be part of a team from @cmri.bsky.social, @sydney.edu.au, the University of Wollongong, and SVI (Melbourne) awarded a $5M NHMRC Synergy Grant to explore: “A mechanistic approach to developing precision therapies for ALT-dependent cancers.”
www.nhmrc.gov.au/funding/find...
Just updated my X/Twitter profile. I suggest you try to encourage any colleagues remaining on that pit to do the same. Such a shame, as it was such an important place of science until not that long ago. :-(
8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷
Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️
Organised by @lapassmore.bsky.social, Dana Branzei, me.
Yep, me too. I have also been getting this error quite a lot in the past couple weeks: "Model inference failed". Usual wait times are 2hr...
New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase".
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
No, not that FANCL!
New paper on FancL mutant mouse just out in @bloodadvances.bsky.social shows essential function of E3 RING ligase activity to phenotypes of #FanconiAnemia plus, Black Friday deal: a new model for testing gene editing therapies: ashpublications.org/bloodadvance...
Finally! We have a FANCM:RMI inhibitor that is cell active and specifically kills ALT+ cancer cells 🎯
@yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇
Registration is open!🧬
Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers.
📅 Deadline for early registration: Jan 10, 2026
🔗 dnarepairmeeting-egmond2026.com
🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing!
docs.google.com/spreadsheets...
🧵 Our latest preprint is available.
It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism.
Read more here 👉 www.medrxiv.org/content/10.1...
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
I attended the Australian Cell Cycle, DNA Repair and Telomere Meeting for the first time, and now I wish I could have attended it earlier.
Thanks much to the organisers and especially to @genomestability.bsky.social for putting such a nice meeting together.
I am looking forward to the future ones!
It was a great honour to present the AGCT (Australian Genome instability, Cell cycle and Telomere) award to Prof Kum Kum Khanna yesterday evening at #ADCTM25. Kum Kum has had an amazing career in discoveries relating to these fields in Australia, and been a remarkable leader and mentor to many.
Its so awesome to have Alan D'Andrea here in Melbourne today for #ACDTM25. What a great talk framed by his classic work on FA!
Ever wondered what S-phase tastes like? 3 lucky presenter prize winners will find out (+Amazon voucher!) at #ACDTM25. You can still register for this fantastic Melbourne meeting Oct 20-22. Official 10 year old taste tester: "lemon excision repair" is the best flavour www.australiancellcycle.org
