two men in suits are dancing on a stage in front of an audience Alt: two men in suits are dancing on a stage in front of an audience

FYI, the David Byrne live set at Coachella starts now on the Outdoor Stage. Stream on the YouTubes. Caught it last week and late stage Byrne still works.

Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment.
So here's a 🧵. /1
www.science.org/doi/10.1126/...

This was my thought. The Shannon entropy in the sequence is basically zero correct? And the only way to change the “stored” sequence would be thru a DNA -> RNA -> Prot pathway. Unless there is evidence of post-translation modification of a subset of Drt3b proteins within an individual org.

This was my thought. The Shannon entropy in the sequence is basically zero correct? And the only way to change the “stored” sequence would be thru a DNA -> RNA -> Prot pathway. Unless there is evidence of post-translation modification of a subset of Drt3b proteins within an individual org.

Text: Instead, Queen Teré was reported to exhibit "guarding" behavior of Arwen and her litter. No other signs of social instabil-

The addition of vertebrae as a function of fertility in a mammal will never cease to amaze me. Plus a primitive version of the Grandmother Hypothesis?

Great talk!! @imartincorena.bsky.social #mits26

Can't wait to read the paper: www.nature.com/articles/s41...

You can make someone cry with a carrot … you really just have to jam it up there.

a man with glasses is saying we 're not so very different you and i. Alt: a man with glasses is saying we 're not so very different you and i. Smiley in Tinker, Tailor, Soldier, Spy.

The juxtaposition of these two roles.

Congrats Aida! An impressive accomplishment.

Harmit, very nice of you to share your serving of cake with everyone 😄

Out of respect to Jacob @drawfeeshow.com I will not comment on this card’s relationship with his soul. @deepblueink.bsky.social

Reaching for the Moon, by Edward Mason Eggleston, 1933 (flipped), 📸 by @godovasquez

Angel at the Tomb of Christ, by Benjamin West, 1813, 📸 by @HancockPhoto

One slice, horizontal. Thickness varies.

Early in the season, but still 👀
@pucksports.bsky.social

#OpeningDay To those who celebrate.
@jasonbeck.bsky.social

Kevin McGonigle's first MLB at-bat comes with bases loaded and 1 out against Nick Pivetta, who just walked in a run. His first pitch is a 2-run double. Check out his reaction at the end.

a stingray is swimming in a tank with senorgif.com on the bottom Alt: A baby skate swimming up a tank side. The eye spots and visible internal organs give the illusion of a smile.

An amazing skate of speakers in my mind 😂
Well done and get more coffee sir.

Circa (c. or ca.)
scRNAseq c. 2010

or pop song

scRNAseq Tik Tok Ke$ha…

Two ink and water color sketches of performers dressed in Moka Pot costumes. One purple, and one dark pink. Lids as hats, base as skirt, and coffee chamber as body.

Still just fascinated with these Moka Pots from the games. Have a feeling I’ll be sketching more.

Pro tip: Socks first, then pants.

Yes, saw this and it’s on my list. Surprisingly hard to find a good ventral view of adult zebrafish anatomy online. I gather the heart is asymmetrical along the long axis, is the digestive tract asymmetrical as well?
I keep thnkng of flat fish & their rotation diversity btw species. Why not w/guts?

Thanks for the reply and thought. It’s informative to hear how/if these things score in a “wins above replacement” frame.
My reaction to most of what I see is, “Yeah, given the internet as input, that’s what you would hope the minimum bar of performance would be.”

The gel that makes the paper; the 99 that don’t.

A large cake in the shape of an armadillo laying down on its stomach. Grey icing covering red velvet cake. The Groom’s Cake from Steel Magnolias.

Meet you in the middle.

NFL primer: Kickoff returns rise after rule tweaks. Concussions, too. The kickoff format, modified each of the past two seasons, has boosted returns but has not reduced concussions to a rate comparable to that of a run or pass play.

After the NFL's latest rules tweaks, the number of kickoff returns surged this season. But so did the number of concussions suffered on those plays.

www.washingtonpost.com/sports/2026/...

Generally interested in these use cases. Are the recommendations a surprise to you given your experience? Would this have been something you would miss, if you sat down and looked at your pers data?
I recognized you can’t A/B test, but how would you judge success over what you normally have done?

snow & stairs, Berlin

cc: @mads100tist.bsky.social
Zebrafish strain/line or adjacent species example?

A guide I have found useful this last year. @harmitmalik.bsky.social FYI.

Plus, normalize z-axis cake slicing.

Photo of a suspended sculpture high inside a grand building, the artwork resembles a blue plump female figure in colourful costume with golden wings

'L’ange protecteur (Guardian Angel)' by Niki de Saint Phalle, at Zurich Main Station #WomensArt