Posts by Alan Rogers
Morez Jacobs et al used 45k genomes to localize Neandertal haplotypes w/i the British; used these to infer the SFS of the introgressing Neandertals; and then inferred population history parameters of the introgressing pop. Also lots about selection. www.biorxiv.org/content/10.6...
Population replacement in Neolithic France at the end of the megalith period. scholar.google.com/scholar_url?...
The Neanderthal population history and the introgression landscape inferred from the UK Biobank www.biorxiv.org/content/10.64898/2026.04...
This is the most delightful thing I’ve ever read
A few years ago, using palaeoproteomics, we identified a tiny hominin bone from Denisova Cave and named it Denisova 17 (D17).
A rather unremarkable sliver.
At the time, I wondered, could it be Denny’s sibling (the Neanderthal/Denisovan hybrid we had just reported)?
Well, turns out: no. 🧵1/4
This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.
“Human ancestors interbred with two distinct populations of distant relatives” nice new preprint by @alanrogers.bsky.social @colinmbrand.bsky.social @timwebster.bsky.social showing that “archaics” & “moderns” interbred with two distinct “superarchaic” populations
🧪🧬💀
Graph showing history of human population size, separation, and gene flow over past 1.5 Ma.
Can anyone tell me what software makes graphs like this (from Cousins, Scally, and Durbin 2025)?
Welcome to Minnesota, fuckers. Also this is super disturbing because the ICE agent's assault rifle appears to fire as he falls down.
This was filmed by a friend near Chicago and Lake last night.
"Trump’s National Security Strategy made one thing brutally clear and that is that the United States is no longer fully shaping its own foreign policy. The document reads like parts of it were written in Moscow and stamped in Washington." www.dailykos.com/stories/2025...
I often restrict sample of loci to those with identical alleles in reference genomes of two outgroup species, chimpanzee and gorilla. But if N of species A is large, different individuals should differ in difference to B.
@peercommunityin.bsky.social is one solution to this problem. We should all support it. #peercommunityin
Here's a link to the website of this course as hosted by the University of Utah: content.csbs.utah.edu/~rogers/tch/...
I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio
Maybe so. The estimated rate of M>N gene flow is lower than that in the other direction, but it would surely contribute.
How much phylogenetic information is in a small sample of proteins? Pastramanis et al answer this question and also discover a puzzle: each protein added to an analysis of modern and archaic humans increases support for a single implausible hypothesis. evolbiol.peercommunityin.org/articles/rec...
A post from Donald Trump reads: “Senator Cryin’ Chuck Schumer is demanding over One Billion Dollars in order to approve a small number of our highly qualified nominees, who should right now be helping to run our Country. This demand is egregious and unprecedented, and would be embarrassing to the Republican Party if it were accepted. It is political extortion, by any other name. Tell Schumer, who is under tremendous political pressure from within his own party, the Radical Left Lunatics, to GO TO HELL! Do not accept the offer, go home and explain to your constituents what bad people the Democrats are, and what a great job the Republicans are doing, and have done, for our Country. Have a great RECESS and, MAKE AMERICA GREAT AGAIN!!!”
The Art of the Deal.
Troff came before TeX, at least in my life. But yes, it was wonderful.
Thanks. I'll look at your preprint.
Very interesting. 2 questions: 1. How large are samples from A and B? 2. Can the result be expressed in terms of a molecular clock instead of a drift clock? A drift clock is usually needed only when one doesn't know which allele is ancestral.
Over multiple generations, you need to account for changes in p_i q_i. If the initial p is near 1/2, then pq changes much less than p does, so you can ignore changes in p_i q_i over short intervals.
In daughter population i, one generation of drift adds a random increment to allele frequency with mean 0 and variance p_i q_i/2n. These increments are independent, so the between-daughter variance would be twice this value.
If I understand you correctly, 1/2n, where n is sample size. But why do we need 2 samples? The Fst of each sample relative to the pop is 1/2n.
He doesn’t remember nominating Jerome Powell.
Fuck it, they killed him live.
This is the consequences when we chose the wrong
direction.
NEVER HAVE I SEEN A MORE APT NATURAL ANALOGY TO THE CURRENT MAJORITY OF THE U.S. CONGRESS. olors Nature The sea squirt digests its own brain after attaching to a rock: Once it finds a permanent home, it no longer needs to think or move.
My old lady neighbor who texts me memes all day is my new favorite person