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Glycobiology: How enzymes make the right choice during biosynthesis The biosynthesis of an important biopolymer called hyaluronan requires an enzyme that discriminates between two different substrates.

How enzymes make the right choice during biosynthesis

Detecting directed motion and confinement in single-particle trajectories using hidden variables Exatrack is a framework for analyzing Brownian, directed, and confined motion using a hidden-variable probabilistic model to extract physical insight into particle diffusion.

Detecting directed motion and confinement in single-particle trajectories using hidden variables

elifesciences.org/articles/993...

Investigating the native functions of [NiFe]-CODH through genomic context analysis Genomic neighborhood signatures delineate catalytic versus putative regulatory CODH clades, establishing a framework for predicting enzyme functionality and guiding discovery of biocatalysts for CO2…

Investigating the native functions of [NiFe]-CODH through genomic context analysis

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DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic…

DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

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Separating selection from mutation in antibody language models Factoring out nucleotide-level mutation biases from antibody language models dramatically improves prediction of functional mutation effects while reducing computational cost by orders of magnitude.

Separating selection from mutation in antibody language models

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Memory Encoding and Retrieval: Rethinking how memories are retrieved Patterns of neural activity called theta oscillations have a role in memory encoding but – contrary to current thinking – do not appear to have a role in memory retrieval.

Rethinking how memories are retrieved

Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity Dysregulated exocytosis of bis(monoacylglycerol)phosphate (BMP)-enriched extracellular vesicles driven by pathogenic LRRK2 activity supports elevated urinary BMP levels and its use as a biomarker for...

Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity

Dynamic modulation of social gaze by sex and familiarity in marmoset dyads A fully automated 3D tracking framework reveals that sex and familiarity strongly shape natural social gaze dynamics in freely interacting marmosets.

Dynamic modulation of social gaze by sex and familiarity in marmoset dyads
elifesciences.org/articles/105...

Peptidoglycan recycling is critical for cell division, cell wall integrity, and β-lactam resistance in Caulobacter crescentus Peptidoglycan recycling is essential for proper cell growth and intrinsic ampicillin resistance in Caulobacter crescentus, highlighting PG recycling enzymes as potential antibacterial targets.

Peptidoglycan recycling is critical for cell division, cell wall integrity, and β-lactam resistance in Caulobacter crescentus

Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.

Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework

Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.

Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework

Human receptive endometrial assembloid for deciphering the implantation window A specialized window-of-implantation endometrial assembloid enables investigation of human endometrial receptivity and maternal-fetal interaction.

Human receptive endometrial assembloid for deciphering the implantation window

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Membrane Biology: Two binding sites are better than one The reasons why two multiprotein complexes – VPS34 complex I and VPS34 complex II – are activated by different Rab proteins are becoming clearer.

Two binding sites are better than one

Teenagers vs teamwork Teenagers cooperate less than adults because they are less motivated to reciprocate fairness and shared cooperation.

Teenagers vs teamwork

A conserved mycobacterial nucleomodulin hijacks the host COMPASS complex to reprogram pro-inflammatory transcription and promote intracellular survival Mycobacterium tuberculosis deploys nucleomodulins to suppress COMPASS-dependent H3K4 methylation, dampening pro-inflammatory gene expression to enhance intracellular survival and uncovering an epigenetic...

A conserved mycobacterial nucleomodulin hijacks the host COMPASS complex to reprogram pro-inflammatory transcription and promote intracellular survival

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Psychedelic Drugs: Reshaping human neurons Human neurons derived from stem cells show increased structural complexity and stronger synaptic connections after exposure to psilocin, the active metabolite of the psychedelic psilocybin.

Reshaping human neurons

The self-interest of adolescents overrules cooperation in social dilemmas Adolescents value reciprocity less than adults, limiting cooperation despite intact learning about others’ behavior.

The self-interest of adolescents overrules cooperation in social dilemmas

Human exploration strategically balances approaching and avoiding uncertainty Strategic avoidance of uncertainty emerges under high cognitive demands, enabling faster decisions without impairing learning.

Human exploration strategically balances approaching and avoiding uncertainty

Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration Rigorous analysis in two knockout mouse lines demonstrates that death receptor 6 is not required for axon degeneration or Schwann cell injury responses following peripheral nerve transection.

Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration

Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration Rigorous analysis in two knockout mouse lines demonstrates that death receptor 6 is not required for axon degeneration or Schwann cell injury responses following peripheral nerve transection.

Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration
elifesciences.org/articles/108...

Nociceptor neurons control pollution-mediated neutrophilic asthma Air pollution activates macrophage-derived artemin, sensitizing TRPA1 nociceptors to drive neutrophilic asthma, revealing new therapeutic targets for refractory airway inflammation.

Nociceptor neurons control pollution-mediated neutrophilic asthma

Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons Psilocin induces a durable neuroplastic state in human cortical neurons by enhancing BDNF signaling, neurite complexity, synaptogenesis, and synaptic network activity through 5-HT2A receptor-dependent...

Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons

Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila Abstract

Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in <i>Drosophila</i>

We are now accepting submissions in Physiology.

We review quantitative experimental and computational research that uncovers mechanisms driving biological function across levels of organisation, with emphasis on cellular and molecular physiology.

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Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila Abstract

Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in <i>Drosophila</i>

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