Moderate hyperthermia impairs dynamic cerebral autoregulation but not its directional sensitivity | Journal of Applied Physiology | American Physiological Society Dynamic cerebral autoregulation (dCA) maintains cerebral blood flow (CBF) relatively constant during rapid fluctuations in mean arterial pressure (MAP). This autoregulation exhibits directional sensit...

Second PhD paper from student Mahmoudreza Taghizadeh now available in J Appl Physiol !

Moderate hyperthermia impairs dynamic cerebral autoregulation but not its directional sensitivity

journals.physiology.org/doi/full/10....

We are delighted to recognise our Exceptional Referees for 2025 🎓 🏆

Visit the webpage below to see the list of referees celebrated for the volume, timeliness, and exceptional quality of their reports & exemplary service to the discipline!

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@lawrencelabr.bsky.social, @marc-antoineroy.bsky.social, Dehnavi, Taghizadeh, @patbrassard.bsky.social (@ulaval.ca), Burma and Smirl (@ucalgary.bsky.social) investigated whether a shorter duration of RSS can identify cerebral pressure–flow relationship directional sensitivity.

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En route to London (ON) to attend the annual meeting of the Canadian Society for exercise physiology and participate in a debate with a giant on the nervous control research field ! That will be a tough, but certainly fun, debate ! #CSEP2025

Forget just living longer. Eric Topol wants to help Americans live better, too. In "Super Agers," the writer and medical researcher maps a path to extending healthspan with AI, targeted drugs, and lifestyle changes.

One thing is aging. Another is aging without the major age-related diseases. Extending healthspan. www.freethink.com/biotech/eric...

6/6 (in response to faster oscillations in blood pressure), a population well adapted to high altitude. Whether this represents an adaptation or a maladaptation remains to be determined.

5/n Preservation of this "hysteresis-like pattern" could therefore protect cerebral vessels from the increases in blood pressure associated with altitude. However, the directional sensitivity in the relationship between blood pressure and cerebral blood flow is absent in Sherpas ...

4/n The results from this analysis suggest that acute exposure and partial acclimatization to high altitude (5050 m) do not influence the presence of directional sensitivity in the cerebral pressure-flow relationship (which is good news!).

3/n We know that changes in cerebral blood flow are better ‘buffered’ when blood pressure acutely increases, compared to when it acutely decreases. This phenomenon (i.e. directional sensitivity or hysteresis-like pattern) could be protective for our brain.

2/n For this work, Shahrzad had access to data collected at Everest base camp from individuals who normally live at sea level (lowlanders) and individuals who are well adapted to high altitude (Sherpas)! A nice collaboration with Jon Smirl, Kurt Smith, Sam Lucas, Phil Ainslie and François Billaut !

1/n Our latest work (PhD paper #1 from Shahrzad Soleimani Dehnavi) now available in the Am J Physiol - Regul Integr Comp Physiol (ahead-of-print and open access) !

journals.physiology.org/doi/epdf/10....

PhD paper #1 from Shahrzad Soleimani Dehnavi accepted for publication in AJP-Regul ! Congrats ! Looking forward to sharing the complete article soon !

Submit your late breaking abstracts for CARNet 2025 today! The deadline is September 30.

We look forward to seeing you all in Fort Worth, Texas in November!

Long-duration head-down bedrest alters human sympathetic neurocirculatory regulation | Journal of Applied Physiology | American Physiological Society This study investigated the impact of long-duration head-down bedrest (HDBR) on the central and peripheral components of the sympathetic baroreflex in males and females. Microneurography was used to measure integrated muscle sympathetic nerve activity (MSNA). Signal averaging was used to quantify sympathetic transduction of mean arterial pressure (MAP) and total peripheral resistance (TPR) in 13 males and 12 females before and after 60 days of −6° HDBR. Under baseline conditions, when analyses were stratified by biological sex, HDBR attenuated transduction of MSNA bursts to MAP responses in males (pre-HDBR: Δ1.4 ± 0.5 mmHg, post-HDBR: Δ1.0 ± 0.4 mmHg; η2 = 0.49, p = 0.005) but not females (p = 0.143). HDBR did not affect baseline integrated MSNA in males or females. Females performed lower body negative pressure (LBNP) at −20, −30, and −45 mmHg. HDBR reduced stroke volume (η2 = 0.89, p < 0.001) and increased TPR (η2 = 0.56, p < 0.001) across all levels of LBNP but did not affect MSNA burst frequency, burst amplitude, or baroreflex gain indices (all p ≥ 0.191). In females, HDBR augmented sympathetic transduction of TPR at −45 mmHg LBNP (pre-HDBR: Δ0.2 ± 0.2 mmHg/L/min, post-HDBR: Δ0.4 ± 0.4 mmHg/L/min; η2 = 0.25, p < 0.001). These data suggest that: (1) biological sex influences the impact of HDBR on baseline sympathetic transduction of blood pressure and (2) among females, vasoconstrictor responses to sympathetic bursts elicited by simulated orthostasis are augmented to compensate for reduced stroke volume after long-duration HDBR.

Long-duration head-down bedrest alters human sympathetic neurocirculatory regulation

journals.physiology.org/doi/abs/10.1...

Prioritizing skeletal muscle health for successful aging Kevin A. Murach talks us through prioritizing skeletal muscle health for successful aging, beginning with a primer on skeletal muscle aging

Prioritizing skeletal muscle health for successful aging “The beneficial effects of exercise on skeletal muscle cannot be overstated, and the impact of healthy skeletal muscle on successful aging should not be underestimated.” www.openaccessgovernment.org/article/prio...

Countrywide natural experiment links built environment to physical activity - Nature By analysing the smartphone data of 2,112,288 participants, in particular observing and comparing the activity of the same individual in two different environments, we find that increases in the walka...

A natural experiment provides evidence for promoting moderate-vigorous physical activity: the importance of walkable cities
www.nature.com/articles/s41...

Regional dynamic cerebral autoregulation in acute poikilocapnic hypoxia | Journal of Applied Physiology | American Physiological Society Dynamic cerebral autoregulation (dCA) of the posterior circulation has been shown to be more pressure-passive compared to the anterior circulation, possibly due to a lower basal vascular tone. In hypo...

Regional dynamic cerebral autoregulation in acute poikilocapnic hypoxia

journals.physiology.org/doi/abs/10.1...

Reduced risk of all-cause and cardiovascular mortality with exercise (and dose-response) throughout adulthood from a systematic review of 85 studies bjsm.bmj.com/content/earl...

Daily use of countermeasures to prevent headward fluid shifts throughout 30 days of strict head-down tilt bed rest | Journal of Applied Physiology | American Physiological Society Strict 6° head-down tilt bed rest (HDTBR) induces a chronic headward fluid shift similar to weightlessness that may underlie development of spaceflight associated neuro-ocular syndrome. We tested the ...

Daily use of countermeasures to prevent headward fluid shifts throughout 30 days of strict head-down tilt bed rest - J Appl Physiol

journals.physiology.org/doi/abs/10.1...

Modulation of the human brain oxygen extraction fraction and metabolic rate in response to hyperoxia: The role of hypocapnia | Journal of Applied Physiology | American Physiological Society Hyperoxia provokes hyperventilation, reducing arterial carbon dioxide pressure (PaCO2), which in turn decreases cerebral blood flow (CBF) and oxygen delivery (DO2). While hyperoxia-induced hypocapnia ...

Modulation of the human brain oxygen extraction fraction and metabolic rate in response to hyperoxia: The role of hypocapnia - from Igor Fernandes’ team in J Appl Physiol

journals.physiology.org/doi/abs/10.1...

Cerebrovascular variability interactions after acute ischemic stroke: insights from directionality analysis based on transfer entropy | Journal of Applied Physiology | American Physiological Society Dynamic cerebral autoregulation (CA) limits fluctuations of mean cerebral blood flow, approximated as mean cerebral blood velocity (MCBv) measured via transcranial Doppler ultrasound, in the presence ...

Cerebrovascular variability interactions after acute ischemic stroke: insights from directionality analysis based on transfer entropy - J Appl Physiol
journals.physiology.org/doi/abs/10.1...

Models of Cerebrovascular Reactivity in BOLD-fMRI and Transcranial Doppler Ultrasound | Journal of Applied Physiology | American Physiological Society The ability of cerebrovasculature to respond to meet tissue demands is vital for normal brain function and health. Cerebrovascular reactivity (CVR), a measure of the responsiveness of cerebrovasculatu...

Models of Cerebrovascular Reactivity in BOLD-fMRI and Transcranial Doppler Ultrasound - J Appl Physiol

journals.physiology.org/doi/abs/10.1...

Here is the latest work from @lawrencelabr.bsky.social (PhD paper #4) related to cerebral pressure-flow relationship directional sensitivity ! Ahead of print in @expphysiol.bsky.social (open access) @jonathansmirl.bsky.social

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The CARNet 2025 website is now live! Information about our keynote and invited speakers, registration, abstract submission, accommodation recommendations, and sponsors is now available.

www.car-net.org/event-list

Marques, Couture, Bussières, Langevin, Poirier, Voisine, Caouette and @patbrassard.bsky.social‬ (Université Laval) examine the effects of noradrenaline and phenylephrine on cerebral oxygen saturation during cardiopulmonary bypass in cardiac surgery.

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Congrats @lawrencelabr.bsky.social for an exceptional PhD thesis defense! You couldn't have finished your PhD any better.

AWESOME JOB ! #proudsupervisor

Caffeine in cerebrovascular research: To withdraw or not to withdraw? Click on the article title to read more.

That is the question !

Caffeine in cerebrovascular research: To withdraw or not to withdraw?

physoc.onlinelibrary.wiley.com/doi/10.1113/...

The big day is almost there for @lawrencelabr.bsky.social ! She will defend her thesis on June 16th ! This will be a great show!

The 4th PhD paper (out of 5) of @lawrencelabr.bsky.social accepted for publication in @expphysiol.bsky.social, just in time for her PhD defense (June 16th) ! Congrat Lawrence and team !

The 14th Cerebrovascular Research Network (CARNet) Annual Meeting will take place on November 12-14, 2025 in Fort Worth, Texas, USA (see flyer attached).

We now invite you to submit your best work for a presentation at our annual meeting! Abstracts are due by July 31, 2025.