We are still accepting applications for the PhD student position in our lab (deadline: May 1st)! Please spread the word!

Happy Golgi Day

My lab in Kiel, Germany, studies the regulation of #glycosylation in the #Golgi apparatus and we are still looking for a motivated PhD student. Please spread the word/get in touch! #glycotime #SPPL3

www.nature.com/articles/s41...

95th Harden Conference: Linking Golgi trafficking and glycan function in Blackburn, UK, 23-26 June 2026. Super earlybird deadline 23 March 2026

The 95th Harden Conference: Linking Golgi trafficking and glycan function taking place 23-26 June 2026 will bring together glycobiologists with the membrane trafficking community to kickstart new collaborations. Learn more here: https://ow.ly/9Eex50YguUY

Ten more days to apply! We are still looking forward to applications from students eager to study #SPPL3 and other proteases and their role in the regulation of #Golgi #glycosylation. #glycotime

Exciting conference next summer! Greatly appreciate the opportunity to present our work.

Congratulations to Master student Daniel Meisinger from our group who received a Research Festival Award for Outstanding Research Achievements for his poser presentation!

We are looking for a motivated PhD student to join our lab! #SPPL3 #glycotime #Golgi #UniKiel

Our institute's new website is online now: www.biochemie-kiel.de

Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!

Reminder: our postdoc and PhD positions are still open. We work across different areas (wet and dry lab), but I am especially after people with a computational biology, bioinformatics, pytorch whisperer kind of background. Protein design and OpenFold/AF also counts.

The proper ad will follow soon, but feel free to get in touch!

We will be hiring soon! #SPPL3 #glycotime #Golgi

SPPL3 again enters the spotlight...

Regulation of podocyte surface proteins by the enzyme A Disintegrin And Metalloproteinase 10 (ADAM10)

doi.org/10.1016/j.kint.2025.04.010

#OpenAccess #kidney #membranousnephropathy #MedSky #NephSky

Happy Golgi day

Great visit in Kiel Biochemistry with Elmar Wolf, Paul Saftig, M. Damme, M. Voß. Talking exciting (lysosome) science at the beautiful Kiel Fjord.

This cover highlights the article ZBTB48 is a priming factor regulating B-cell-specific CIITA expression by Grishma Rane, Dennis Kappei and colleagues. The study identifies how ZBTB48, represented as pangolins, binds to two distinct binding sites at the B-cell-specific promoter of CIITA, the master regulator of the MHC-II immune gene expression program, to activate the CIITA "switchboard" and initiate CIITA expression. This in turn causes expression of MHC-II molecules, antigen-presenting complexes at the cell surface, here represented by illumination of the iconic supertrees found in Singapore's Gardens by the Bay. Cover concept by Grishma Rane and Dennis Kappei, scientific illustration by DrawImpacts

Our final 2024 issue!
Highlight: New players in lysosomal sorting via mannose-6-phosphate
mRNA deadenylation & decay relations
Plant ALBA proteins facilitate m6A reading
METTL3/MYCN cooperation
and lots more!
Cover: Grishma Rane, @denniskappei.bsky.social et al
www.embopress.org/toc/14602075...

Tumor‐Expressed SPPL3 Supports Innate Antitumor Immune Responses Tumor and immune cells interact through receptor–ligand interactions. B3GNT5 produces nsGSL on tumor cells which is regulated by SPPL3. When SPPL3 is absent, elevated nsGSL levels hinder receptor–lig...

Interesting paper by Verkerk et al. further supporting that loss of #SPPL3 can lead to tumour immune evasion.
onlinelibrary.wiley.com/doi/10.1002/...

New players and targets in mannose 6-phosphate-dependent lysosomal sorting | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Please also have a look at the News & Views article by Nikita Zubkov and Sean Munro @cellbiol-mrclmb.bsky.social that accompanies our EMBO J paper: www.embopress.org/doi/full/10....

Out now in The EMBO Journal: Our collaborative new #Golgi #glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging. tinyurl.com/jkv26nhh