Would be good for targeted methylation sequencing if the efficiency was better

I liked this paper, but thought the conversion rate was quite low for profiling methylation unless I missed something?

Very proud of my 2nd PhD student, Pedro Romero Charria, who defended his viva yesterday. Big thanks to @michael-imbeault.bsky.social and Roman Arguello for the discussion. Pedro's main work on #6mA in protists was published late last year (www.nature.com/articles/s41...), but there's more to come!

There are Science papers and then there are *I just dropped and shattered my mug of coffee Usual Suspects style* Science papers www.science.org/doi/10.1126/...

Development of PROTACs for targeted degradation of oncogenic TRK fusions Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRKs) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whi...

Proud to share our latest paper in @rscchembio.rsc.org, where we tackle oncogenic TRK fusions. Together, @sauravk05.bsky.social and Jiewei Jiang develop potent and selective degraders of the TPM3-TRKA fusion, a key cancer driver. pubs.rsc.org/en/content/a...

Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In m...

Out now in @science.org
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape | Science www.science.org/doi/10.1126/...

Congratulations Elzo, Tineke, and teams! Look forward to digging into this.

New paper in Genes & Dev: we dissected how Sox2 — a key pluripotency TF — is regulated by a distal enhancer cluster (SCR) 100 kb away. The results challenge simple models of cohesin-mediated loop extrusion of gene regulation. genesdev.cshlp.org/content/earl... 🧵

Thanks so much Claudia for the info!

Reposting this. Any additional thoughts? For RNA? Any help greatly appreciated!

Help needed: I know this has been discussed before - what are people doing now that phase lock tubes have disappeared from the market? Is everyone making their own and that's why companies are not selling them anymore? If so, what is the best vaccum grease you would recommend? 🤷‍♀️

Booo!

Really proud to see this. Huge congratulations to @helenfoster.bsky.social on the Biochemical Society Early Career Award, well deserved!!

Four images featuring Matt in his office, the film crew setting up a couple of shots and Max from Matt's lab

We’re delighted to share a ‘behind-the-scenes’ peek of SBS TV filming Matt Higgins @parasitematt.bsky.social and his group this week for a documentary on the Future of Medicine with AlphaFold. It will air in South Korea in early May 2026. Watch this space for more!

Wow! Amazing Tom. Well deserved!

Delighted to be awarded The Colworth Medal! Thanks especially to lab members, mentors and colleagues past and present.

Sorry for the cliché: not sure how to avoid it...

I am very honoured to join such an illustrious list of previous winners

And – of course – the credit largely belongs to the fabulous people I have been lucky enough to work with @dunnschool.bsky.social and earlier @mrclmb.ac.uk

Congratulations to our Head of Department, @mjafreeman.bsky.social, awarded the @biochemsoc.bsky.social Centenary Award!

This recognises his contributions in the field of intramembrane proteases and pseudoproteases, and his commitment to supporting talent within the scientific community.

The Biochemical Society 2027 Centenary Award presented to Professor Matthew Freeman from University of Oxford, UK.

A leader in the cell biology of signalling, the 2027 Centenary Award is presented to Matthew Freeman in recognition of his pioneering discoveries into the biological significance and mechanisms of rhomboid intramembrane proteases and pseudoprotease and unwavering commitment to mentorship!

Congratulations Matthew, very well deserved!

Sun shining hazily through trees, very long shadows, blue skies

Good morning beautiful Edinburgh 😎

It is a bit insane that the Artemis II crew started from the earth, flew around the moon, and came back to the earth, faster than it takes for the journals to send your paper out for review.

Sharing this very sad news. Greg influenced many beyond his lab and across fields. This is a very nice write up from CRUK-CI highlighting what he meant to many of us. Thank you for putting into words what many of us can't right now.

www.cruk.cam.ac.uk/news/in-memo...

Saddened to learn of the death of Greg Hannon, a former CSHL colleague and giant of modern molecular biology www.cruk.cam.ac.uk/news/in-memo...

Congratulations Duncan and team!

Very pleased to say that the paper version of our study examining the role of de novo DNMTs in cancer-associated hypomethylation is now out in @plos.org Genetics 🎉:
doi.org/10.1371/jour...
You can read more on the previous thread but here is a summary of the main updates! #epigenetics 🧵 1/9

shocked and sad to hear of greg hannon's passing. even more inexplicable to learn at CSHL Regulatory RNAs meeting, which greg started (with elisa izzauralde, another premature loss to the RNA community). so many textbook discoveries made by his lab in mcclintock. we pour one out for greg at the bar.

Hands up if you love chromatin & structural biology 🙋‍♂️

On Friday April 24th we will be joined by @kjarmache.bsky.social from NYU for his webinar 'Chromatin-Modifying Complexes in Gene Activation and Silencing'.

Register here: us06web.zoom.us/webinar/regi...

@activemotifusa.bsky.social

Radu's group does some really nice work. Can highly recommend them and the environment at Blizard!

Super happy to share the published version of our study: “Germline sequence variation within the ribosomal DNA is associated with human complex traits” in Cell Genomics www.cell.com/cell-genomic...!