Love it, thanks Joseph!

#IDsky

Interested in thoughts on any of these trials as well as suggestions for other literature to include. @uwidfellowship.bsky.social @pergamic.bsky.social @rupalij.bsky.social

Important ID publications 2025 Cohen.pdf | Powered by Box

Want the full reading list?

See “Essential Publications in Infectious Diseases 2025” link below, with more details on essential literature from this year:

pdf: app.box.com/s/ny7m9d0pdi...

Ppt on request

Thanks for reading and for everything you do.

8️⃣ Big Picture Takeaways

📌 Guidelines often rest on limited evidence
📌 Treatment durations keep shrinking—even for TB
📌 PO often >> IV. Safe and patient centered.
📌 RSV prevention is a true breakthrough
📌 Despite setbacks, this is still an exciting time to be in ID 👇

7️⃣ Vaccines: A Standout Year

RSV vaccines: ~80–90% reduction in RSV hospitalizations in adults ≥60

mRNA flu vaccines: superior efficacy vs standard flu shots, with more reactogenicity

Emerging data suggest mRNA vaccines may synergize with cancer immunotherapy

Woot woot! 👇

6️⃣ COVID Therapeutics: Reappraisal

Large real-world data suggest Paxlovid offers little benefit in highly vaccinated older adults.
Its role in 2025 is increasingly narrow and should be framed honestly. 👇

5️⃣ Antimicrobials: Find the niche

Cefiderocol: noninferior, not superior; reserve for salvage

Olorofim: bright spot in mold infections. Rare mold trials are hard!

Dalbavancin: viable consolidation therapy after S. aureus bacteremia clearance

Gepotidacin is here! 👇

4️⃣ Mpox: A Hard Lesson in Evidence

Randomized trials now show no clinical benefit of tecovirimat for mpox.
Animal models and uncontrolled observational data may have misled us—an important cautionary tale for outbreak therapeutics. 👇

3️⃣ STIs: Paradigm Shifts

Two practice-changing NEJM trials:

Male partner treatment for bacterial vaginosis cut recurrence nearly in half

Twice-yearly lenacapavir for HIV PrEP showed ~90% protection

Implementation, cost, and access will determine real-world impact. 👇

2️⃣ Vector Control: Entomology ≠ Outcomes

Three trials, three lessons:

Ivermectin MDA ↓ malaria incidence

Permethrin baby wraps ↓ infant malaria by 66%

Indoor residual spraying dramatically ↓ mosquitoes but not infections

Bottom line: endpoints are key 👇

1️⃣ Guidelines: Shorter, Oral, Individualized

2025 continues the trend toward less is more:

CAP: shorter courses (3–5 days) if stable

TB: 4-month regimens now endorsed for select patients

cUTI: oral step-down even with bacteremia is appropriate

Individualize guidance!👇

picture of books, with text: "essential publications in ID, 2025 edition"

🧵 Essential ID Papers for 2025: A Clinician’s Guide

Each year brings a flood of amazing ID literature.

Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines.
👇

Love this— adding it to my teaching folder. Thanks for sharing Lisa!

Nice work! @drrossanarosa.bsky.social have you found a disinfectant for inpatient rooms that can be used universally regardless of colonization status or do auris rooms get their own cleaning/disinfection protocol?

Welcome! We’re thrilled to have you.

Congrats!

Welcome!

Very cool!

Very cool thanks for sharing.

Congrats!

Let us know what you decide!

💔 so very sorry to hear

mount rainier

orca jumping in front of space needle

🚨📣🚨📣
We're hiring!

Open search for Associate Director of Infection Prevention at UW Medical Center

Work in amazing academic environment with a phenomenal team.

Fantastic quality of life.

Did I mention protected time for scholarly activities?

DM w q's

apply.interfolio.com/160509

#IDsky

@pergamic.bsky.social @johnlynchid.bsky.social @paulpottingermd.bsky.social @germhuntermd.bsky.social @drrossanarosa.bsky.social @jlsalinas.bsky.social

Graduating fellows with interests in scholarship, med-ed, IP and clinical service are welcome to apply!

mount rainier

orca jumping in front of space needle

🚨📣🚨📣
We're hiring!

Open search for Associate Director of Infection Prevention at UW Medical Center

Work in amazing academic environment with a phenomenal team.

Fantastic quality of life.

Did I mention protected time for scholarly activities?

DM w q's

apply.interfolio.com/160509

#IDsky

What a great match! Can’t wait to meet them.

Thanks for sharing

Amazing opportunity

Great thread, thank you!