Online Now! An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines that enables production of highly functional stem cell-islets suitable for type 1 diabetes cell therapy. https://ow.ly/RUML50YKuVP
ISSCR | Cell Press
In this anniversary episode, Janet Rossant is joined by a few of our past guests who helped define the conversations of the past five years. Revisit where their work stood then, explore where it has gone since, & take a closer look at what lies ahead 👉https://ow.ly/WcRv50YJ0Uo
Check out this new intestinal #organoid research: Phenotypic screening identified that glycyrrhizin confers protection against tumor necrosis factor-induced cell death, which may be a novel therapeutic compound for Crohn’s disease. https://ow.ly/VZvQ50YKuMG
New #RareDisease research! Bosma arrhinia microphthalmia syndrome (BAMS) is marked by the absence of a nose and eye/reproductive anomalies, which may result from impaired differentiation to cranial placode cells and changes in cell adhesion. https://ow.ly/kRPX50YGFGl
Stem Cell Reports, ISSCR's open-access, peer-reviewed journal, has been named the Official Conference Journal of the BaCell3D Organoid Conference, taking place 22-24 June 2026 in Basel, Switzerland. Read more 👉 https://ow.ly/mesl50YInK1
Chemotherapy-induced thrombocytopenia (CIT) is a severe complication in elderly cancer patients. New research shows that dietary restriction mitigates CIT in aged mice via mitochondrial potentiation in hematopoietic stem cells and megakaryocyte progenitors. https://ow.ly/VpFm50YEMX5
A nuclear receptor screen identifies Rora as a dose-dependent regulator of cell fate. Transcription factor dosage—not just identity—drives reprogramming efficiency, pointing to nuclear receptor modulation as a lever for cell plasticity https://ow.ly/B4jU50YEN1g
A screen of 49 nuclear receptors identifies the ROR subfamily as OKS (OCT4/KLF4/SOX2) enhancers. Rora acts as a dose-dependent regulator of cell fate, tuning reprogramming efficiency. https://ow.ly/XPlQ50YEMWN
Cell Press | The Gairdner Foundation | SickKids Foundation
Stem Cell Reports is pleased to announce the appointment of Hongmei Wang, Ph.D., as an Associate Editor. Dr. Wang is a professor of State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS).
Read more 👉https://ow.ly/rfEu50YGw9E
New research from Duke University in Stem Cell Reports uses multimodal human podocyte injury models to discover kidney disease targets, highlighting the predictive power of human-relevant experimental models. https://ow.ly/5gsa50YEMWk
Cell Press | The Gairdner Foundation | SickKids Foundation
Online Now! A semi-automated multi-electrode arrays (MEA) spike sorting method for high-throughput assessment of cultured neurons; enhances the resolution & utility of MEA in disease modeling and drug development using hPSC-derived neurons. https://ow.ly/lzkW50YEMVV
Stem Cell Reports is proud to be the official meeting journal for the 20th Annual Wisconsin Stem Cell Symposium! Learn more about the event 👉 https://stemcells.wisc.edu/7376-2/
Thrombopoietin (THPO)-driven neonatal hematopoiesis establishes the hematopoietic stem cell and multipotent progenitor cell hierarchy. While its role is limited in adults, THPO is critical during early development for a structured hematopoietic system. https://ow.ly/sOca50YARe5
New! 3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease, providing platform for mechanistic studies and therapeutic testing. https://ow.ly/XkVS50YALSQ
Cell Press | The Gairdner Foundation | SickKids Foundation
Stem Cell Reports announces measures to strengthen scientific rigor with new publication standards today. Advancing transparency, reproducibility, and trust in stem cell science.
www.isscr.org/isscr-news/s...
@isscr.org @cellpress.bsky.social @sickkidsvs.bsky.social
The challenges of choosing your pluripotent stem cell line. A new letter explores whether to use a “ready-to-use” hPSC line or make a new one, and how that choice impacts suitability for the intended clinical indication and resulting cell types. https://ow.ly/5rCu50YALJY
New review in Stem Cell Reports from CiRA, Kyoto University discusses the developmental origins and functions of microglia, current differentiation approaches, and how these models help elucidate disease-relevant phenotypes and molecular mechanisms in neurodegeneration. https://ow.ly/q8qF50YALC3
Online now: Mechano-electrical stimulation enhances peripheral nerve regeneration by activating and directing neural crest stem cell differentiation, supporting a novel therapeutic approach to stem cell modulation for nerve repair. https://ow.ly/8Ayu50YALtR
Out Now in Stem Cell Reports! A practical framework for hiPSC model development with stem cell-specific guidance on reporting diversity and a four criteria tool (purpose, plausibility, readiness, and power) to determine when and how to incorporate diversity in research. https://ow.ly/qkSE50YwSug
Diversity of cortical progenitors directs neuronal layer formation and regional glial patterning supporting a model in which fate potential and timing co-regulate the spatial and laminar organization of cortical cell types. https://ow.ly/gjc850YwSjP
New from CiRA in Stem Cell Reports! Deuterosomal cells are the responsible lineage for multiciliogenesis in human airway differentiation. An iPSC-based platform for investigating mechanisms underlying airway multiciliogenesis and modeling primary ciliary dyskinesia. https://ow.ly/8afr50YwSbK
Toward standardized iPSC testing: A multi-year international study highlights variability in flow cytometry (pluripotency) and qPCR (genomic integrity) assays, underscoring the urgent need for harmonized QC to support global adoption of iPSC-derived therapies. https://ow.ly/s1G850YwS6f
Propofol, a common anesthetic, shows region-specific effects in human forebrain organoids, enhancing growth, neuronal excitability, and action potential activity. A new model to study anesthetic impacts on early brain development. https://ow.ly/XGvE50YwRUK
New research from the UC Davis School of Medicine : A new humanized engineered heart tissue platform provides a more sensitive system for evaluating cardiotoxicity and is more stringent than conventional monolayer approaches. #xenobiotics #drugscreening https://ow.ly/Ljl850YwRJ8
New study presents results from the CIRCA-19 trials evaluating umbilical cord–derived mesenchymal stromal cells for severe COVID-19 acute respiratory distress syndrome. Cells were well tolerated and linked to improved clinical outcomes & recovery from lymphopenia. https://ow.ly/Mc1k50Yt8BR
Stem Cell Reports is proud to be the Official Meeting Journal of the 20th Annual Wisconsin Stem Cell Symposium, taking place in Fitchburg, Wisconsin, USA on 15 April 2026. Learn more: https://ow.ly/AaHY50Yw013
Listen to the latest episode of The Stem Cell Report podcast to explore how the guests developed new laboratory models to study Merkel cell development using mouse whisker tissue cultures, mouse skin organoids, and human skin organoids. https://ow.ly/fNnw50YrsVA
Online Now! Nuclear Lipin1 recruits HDAC2 to epigenetically repress SREBP1-dependent lipid synthesis and myelination in hypoxic preterm white matter injury, offering targets for white matter repair in preterm infants. https://ow.ly/7ry150Yt8tB
Cell Press
New article highlights Korea’s new Advanced Regenerative Medicine Treatment (ARMT) category under its amended regenerative medicine law, focusing on patient access, review processes, safety monitoring, ethical safeguards, and lessons from Japan’s comparable framework. https://ow.ly/6kyf50Yt8ps
New research from RIKEN: Canonical & non-canonical WNT signaling pathways sequentially orchestrate early retinal morphogenesis and environmental factors within the host retina strongly drive the alignment and functional integration of graft photoreceptors. https://ow.ly/LChR50Yqg7p
ISSCR
