Molecular insights into how the motions of the β-barrel and POTRA domains of BamA are coupled for efficient function Nature Communications - BamA is the catalytic core of the BAM complex, which inserts proteins into bacterial outer membranes. Here, the authors show that hinge flexibility between BamA’s...

See our latest paper on BAM action. Great work to the team and super collaborations with @naranson.bsky.social @antoncalabrese.bsky.social and @Jean Francois collet. Have a read rdcu.be/eJjDp

Paradoxical Activation of GCN2 by ATP-competitive inhibitors via allosteric activation and autophosphorylation Recently it has been found that General Control Non-derepressible 2 (GCN2) can be activated by an array of small molecule ATP-competitive inhibitors, including clinically relevant compounds such as Po...

Congratulations to Graham Neill who passed his PhD Viva today! 👏🎉👏🎉First PhD from the lab! Many thanks to Tony Ly from Dundee SLS and @antoncalabrese.bsky.social from Leeds for grilling Graham on all things kinases + hdx-ms. Read about Graham's Research on GCN2 here: www.biorxiv.org/content/10.1...

Pleased that you like our work! We’re excited to keep developing these and other chemistries 😄

Design and Characterisation of Photoactivatable and Lysine Reactive o-Nitrobenzyl Alcohol-Based Crosslinkers Photoreactive groups are invaluable tools in structural proteomics, offering reagent-free activation and temporal control of protein labelling. However, traditional UV-activatable functional groups of...

Delighted to share our latest preprint on the design of photoactivatable and lysine reactive oNBA-based reagents for chemical crosslinking-mass spectrometry. We think that these new tools will enable a range of novel structural proteomics applications! www.biorxiv.org/content/10.1...

Amazing efforts from first author @francescachandler.bsky.social and collaborators Roger Greenberg, Joseph Salvino, Francesco Del Galdo and their teams. @pennmedicine.bsky.social @wistar.org @astburycentre.bsky.social @astbury-bsl.bsky.social
@antoncalabrese.bsky.social
@bioscienceleeds.bsky.social

Delighted to see our paper online in JACS! We studied the interaction of TDP-43 with RNA oligonucleotides by HDX-MS, and discovered RNA-sequence dependent differences in the mode of RNA engagement by the RRM domains @thom-mass.bsky.social @emilyjbyrd.bsky.social @monolejnik.bsky.social

CASE Project: Overcoming host cell protein contamination in the preparation of biopharmaceuticals at University of Leeds on FindAPhD.com PhD Project - CASE Project: Overcoming host cell protein contamination in the preparation of biopharmaceuticals at University of Leeds, listed on FindAPhD.com

We are looking for a PhD student to join our group, working on a collaborative project with Immunocore to use structural MS to improve the manufacturability of biopharmaceuticals - please pass on details to anyone who might be interested in the project. www.findaphd.com/phds/project...

Labrador starting intently at a cup of whipped cream

Spending Saturday out and about with this guy… made sure to treat him to a puppacino for being such a good boy! 🐶

👋🏻👋🏻 I work with fantastic team at the University of Leeds, and together we aim to develop and utilise mass spectrometry and biophysics to study protein structure/function. We are interested in intrinsically disordered proteins, chaperones, amyloids, viral proteins, condensates, ribosomes and more!