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Posts by Sofiya Hupalo

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Where U.S. science has been hit hardest after Trump’s first year The Trump administration has slashed the number of grants from the National Institutes of Health, with far fewer focused on women, cancer and mental health.

Those of us doing research related to women’s health have been hit particularly hard by the govt’s sabotage of the NIH. I spoke to WaPo for this piece, as painful as it was to discuss the reality my lab is facing. www.washingtonpost.com/science/2026...

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One month left to apply 👇👇👇

Wondering if you're eligible or have other questions? DM us or email dpnjournal@acnp.org

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Just wow 🤩

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Interested in writing a Primer that bridges psychiatry and neuroscience?

💫 Email us your idea at dpnjournal@acnp.org 💫

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Can large language models help the mental healthcare system keep up with growing demand?
Can large language models help the mental healthcare system keep up with growing demand? YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN)

Can LLMs help the mental healthcare system keep up with growing demand?

This Deep Dive explores whether a RoBERTa LLM can detect anxiety or depression in text, showing accuracy similar to human experts & paving the way for more accessible mental health evaluation.

youtu.be/TJ4IKAIU0Ss?...

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Yeah, it’s unfortunately a lose-lose situation these days given the dysfunction/understaffing at NIH. Burn a year at current U or move the lab to the new U and wait ~6-12 months for the grant to transfer.

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Yep, a lot depends on the institution relinquishing the grant, while the new institution moves quickly to put in the transfer. ICs have incentive to process transfers as 'anniversary transfers' if it's close to end of budget year (less work for them), which is why ICs sometimes delay transfers

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Depends on IC and staffing levels in Program/GM. Also depends on timing - how close you are to the move & the end of fiscal year. If award is approved for payment & end of FY is nearing, NIH will move to award more quickly. Could also talk to PO & frame the move as hypothetical to get more intel

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abstract image of brain made up of colorful interconnected blocks

abstract image of brain made up of colorful interconnected blocks

📢 We’re excited to announce the next call for applications for the DPN Editors' New Investigator Award! This award waives the article processing charge ($2290) for new investigators who aim to publish an original report in DPN.

Apply by May 18th!

Details: www.nature.com/dpn/announce...

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If you’re a new PI in the field of digital psychiatry/computational neuro and are preparing a manuscript, consider applying for this award 👇🏻

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NOFO are dead…and that is not the actual problem A substack blog entry from NIH Program Officer Elizabeth Ginexi outlines the sharp discontinuation in the issuance of Notices of Funding Opportunity (NOFO) at the NIH in 2025 and 2026. These NOFO (…

NOFO are dead...and that is not the actual problem drugmonkey.wordpress.com/2026/03/16/n...

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The next few yrs are likely to be EXTREMELY bad for science funding. Given what we've seen from this admin.

Expect the grant system to work differently for years into future, unless stopped: Much lower success rates, $ sent to Trump allies and away from univs and blue areas

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💯

Unlike a year ago, we now know the strategies this administration is using to defund/disrupt US biomedical research. Sadly, other current events mean this issue is not getting enough media attention.

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Abstract image of building blocks making up a brain

Abstract image of building blocks making up a brain

🌟Announcing the next cohort of the DPN Editor’s New Investigator Waiver Award recipients🌟

Dr. Nicole Zürcher, @nicolerzurcher.bsky.social
Dr. Jennifer Goldschmied, @jengoldschmiedphd.bsky.social
Dr. Sarah Sperry, @drsarahsperry.bsky.social

Congratulations! We're proud to support your work👏

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Tracking teen depression risk through brain connectivity and text message data
Tracking teen depression risk through brain connectivity and text message data YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN)

Our new Deep Dive covers a study by @carterfunkhouser.bsky.social, @dpagliaccio.bsky.social & colleagues, which linked EEG-based brain connectivity patterns with emotional expression from text messages to identify neural markers of depressive symptoms in teens

youtu.be/a_yXb3wERfo

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Very cool, congrats!!!

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Could you share publication(s) supporting the antidepressant actions of 5HT2A receptor antagonists in humans (statement #3)?

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Happy to see this conversation happening. As someone who withdrew from their 1st attempt at PhD due to mental health, way back in the mid-90's, it was very difficult to overcome that obstacle when applying to PhD programs again. I was always seen as a risk...even after completing a masters degree.

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Diversity supplements weren’t just for folks from underrepresented racial/ethnic backgrounds. Eligibility extended to first gen college students and researchers with disabilities, among others

Cancelling these supplements limits opportunities for the next generation of scientists, as explained here

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Recapping the #ACNP2026 study group, “Centering Lived Experience in Psychiatric Neuroscience Research”

We asked the panelists, what could NIH leadership do to be more supportive of trainees with non-traditional career paths, which is common among researchers with lived experience of mental illness?

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Modernizing the National Institutes of Health: Faster Discoveries, More Cures | The U.S. Senate Committee on Health, Education, Labor & Pensions Full Committee Hearing on February 3, 2026 at 5:00 AM

I'm on Capitol Hill watching NIH director Jayanta Bhattacharya testify to the Senate HELP committee.

Thankfully I haven't been escorted out of this event (yet). Here's what I'm following. You can also watch live here:
www.help.senate.gov/hearings/mod...

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Excellent, I didn’t see it come out, thanks for sharing 😁

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Absolutely! I have been meaning to revisit this poster in the ACNP portal, there was lots of good data in there !

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A huge thank you to Dave Kupferschmidt — my co-first author — who continued the momentum on this project after I left the Gordon Lab and shepherded it to the finish line ✨

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We observed that SETD1A haploinsufficiency disrupts beta (and to lesser extent gamma) synchrony between the PFC and thalamic nucleus reuniens during working memory performance. Unlike some other SCZ genetic risk models, we did not observe broader hippocampal–prefrontal synchrony deficits.

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Excited to share this preprint of my postdoc work, only several years late to the party 🎉

We examined how loss of function in SETD1A, a high confidence schizophrenia risk gene, impacts neural synchrony across circuits supporting working memory in mice.

www.biorxiv.org/content/10.6...

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Very cool! Just out of curiosity, what proportion of prelimbic gabaergic interneurons are positive for cortistatin? Is that similar to what’s seen in human brain?

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New paper out on cortistatin neurons and their role in regulating fear and cortical hyperexcitability in the prelimbic cortex! This one has been a fun ride 🧵 www.biorxiv.org/content/10.6...

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Survey: Should neuroscience focus on big team science? Learn which types of projects are better for big team science versus smaller-group support.

Should neuroscience focus on big team science or the traditional model? Explore what survey respondents had to say about it: www.thetransmitter.org/funding/shou...

#neuroskyence #StateOfNeuroscience

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A probabilistic deep learning approach for choroid plexus segmentation in autism spectrum disorder - NPP—Digital Psychiatry and Neuroscience The choroid plexus plays an important role in brain health and immunity and may be altered in autism spectrum disorder (ASD). To analyze large imaging datasets, a method to automatically delineate thi...

🆕in DPN:

Bargagna et al used a probabilistic deep learning model to automate MRI segmentation of the choroid plexus, demonstrating accurate results in an autism cohort and quantifying model confidence across multiple datasets.

www.nature.com/articles/s44...

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