“CELeidoscope: quad-fluorescent strain for tissue-specific spectral single-cell analyses”. Engineered a C. elegans strain that enables spectral sorting of multiple major cell types within a single strain population. Led by Clair Henthorn and Natalia Betancourt. www.biorxiv.org/content/10.6...

So much friction!

Coolest class demo ever. What were the results?

lol I learned this as “double and add 30” (since of course everyone wants to convert from C to F not other way around!)

David Botstein, a titan within the scientific community, died last week. GSA mourns his passing and celebrates his legacy.

Read more about his significance to our community in this thread ⬇️🧵

“But that’s not the weird part!”

Extra “kudos” to those who caved pre-emptively to this now defunct directive

Large brick wall with a tiny white signat the base of the wall that says "Slavery was real"

"Slavery was real"

Tiny sign at the base of a brick wall that, until yesterday, held panels about the people enslaved by George Washington.

Presidents House, Philadelphia.

share.inquirer.com/qkghqI

Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...

Research Specialist A/B University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...

The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...

Evolution of nervous systems: Molecular divergence in a conserved body plan Comparative inter-species single-cell atlases of Caenorhabditis whole embryos and larval nervous systems reveal deep conservation of cell type identit…

highlight of two recent fantastic comparative inter-species single-cell atlases, by @live-large.bsky.social from @jisaacmurray.bsky.social, and Itai Toker from Oliver Hobert's lab
www.sciencedirect.com/science/arti...

Yay thank you for all of your amazing work and for sharing this fabulous news!

I think everyone is certain what the number is. Not sure the number they are certain about is the same though…

Go worms! #worm25

Worm25 has been absolutely fantastic so far-congrats to everyone for your amazing work! One striking change in the talks this year is it seems like the consensus number of neurons in the adult hermaphrodite has returned to 302 after a few years at 300. Is CAN back?

@live-large.bsky.social @junhyongkim.bsky.social @rupakhanal.bsky.social

🤯 @jisaacmurray.bsky.social!!!!

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...

Despite all that is going on, we are still all working on our science. Our 2nd collaboration with @jisaacmurray.bsky.social‬ and Bob Waterston (UW) is out:

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae | Science www.science.org/doi/10.1126/...

Different species, same cell lineage, some gene expression patterns changed, others not so much…lots to dig into here! From @jisaacmurray.bsky.social lab

I won’t summary all the results here but interesting variation across cell types in the degree of conservation, examples of heterochronic evolution, and insight into the expression fate of duplicated genes.

These two species have nearly identical lineages despite having genome sequences nearly as different as human and chicken. This allowed us to explore by single cell RNA-seq how progenitor and terminal cell types vary in the same cell across this long evolutionary distance.

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...

Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...

CGC1, a new reference genome for Caenorhabditis elegans The original 100.3 Mb reference genome for Caenorhabditis elegans , generated from the wild-type laboratory strain N2, has been crucial for analysis of C. elegans since 1998 and has been considered co...

After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off.
But here's the genome now!
www.biorxiv.org/content/10.1...

My first Bluesky paper post! I’m pleased to announce the publication of our single-nucleus atlas of adult neurons from wild-type and long-lived, better performing insulin receptor (daf-2) mutants, by Jon St. Ange and Yifei Weng et al.DOI: 10.1016/j.xgen.2024.100720

Conserved autism-associated genes tune social feeding behavior in C. elegans - Nature Communications C. elegans aggregate in large clumps during feeding. Here, the authors find conserved autism-associated genes mediate distinct molecular and circuit signaling components that tune C. elegans feed...

New paper ALERT!! Mara Cowen, PhD discovered and defined how conserved autism-associated genes modify a 'social' behavior in C. elegans!! So proud of her work in the lab!
www.nature.com/articles/s41...

A reminder for new folks. BlueSky does not have an algorithm to raise posts of interest. It is incumbent upon you to do so via reposting. Liking things only provides feedback to the poster but does not promote the post. The signal to noise ratio is taking a brief beating, so great to help curate.

👋