Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...

One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.

www.biorxiv.org/content/10.1...

Wow! Very impressive work 🤯

I tried the previous version on my preprint, and the feedback was pretty impressive and useful 🧐🔬

Bioinformatician - Uppsala University Bioinformatician, Department of Organismal Biology, Uppsala University

The @scilifelab.se ancient DNA unit is looking for an bioinformatician placed at Uppsala University. This is a great way to be part of diverse #aDNA research projects as a staff scientist with permanent (!!) employment:

www.uu.se/en/about-uu/...

📢 Dear lovers of prokaryotic chromosomes:
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky

Poster advertising the Biology and Physics of Prokaryotic Chromosomes conference that will be held in York, 16-19 September 2025.

Just few days left to register for this chromosome biology fête! 🧬🧬🧬

⏳📆 16 July

www.eventsforce.net/biochemsoc/f...

@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

couldn't complete the assignment, my lab was destroyed | אין מעבדה, תרקדו עכשיו עם כתוביות YouTube video by Shahar Halevi | שחר הלוי

"A missile attack is not going to hold back science, science is held back by itself" 🤣
youtube.com/shorts/FMOi-...

I can add my n=2 anecdotal experience.
I suffered a lot from allergies back in Israel, and since moving to Sweden, I'm completely allergy-free 🙌 (but every home visit, they come back with a vengeance!).
My partner had no allergies back home, and here she does 🤧

This is how you revolutionize science 🕺
#TCTeAC

Woodstock Night Science is trending more than Trump AND Nature! #TCTEAC

🔬

That was me 😊🦠

I used Memrise when I started to learn Swedish (they also have Polish). I don't know if they use AI nowadays, but anyway, they rely a lot on short clips of a variety of native speakers.
www.memrise.com

We got today samples of iSpacer from SunJinLab.
www.sunjinlab.com/ispacer-sele...
It seems promising, although might be a bit too thin on the short side of the rectangle.
I'll update once we've tested it properly.

Rules of Engagement YouTube video by Johan Gibcus

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...

There's a lot of joy in doing science and Woodstock Night Science (June 10-13 in Prague) will be a celebration of the science that we know and love. Many exciting talks & innovations that will push the boundaries of what a scientific conference can really do.
woodstock.img.cas.cz Only 40 spots left!

We are using them, and also our neighboring lab.
Johan Elf & Magnus Johansson labs, Uppsala University, Sweden

Fellow bacterial cell biologists, message me if you use @thermofishersci.bsky.social Gene Frames for microscopy!
Thermo are planning to discontinue these in September but have indicated they will look into this further.
If I make list of labs using them Thermo might not kill the product
Please RT🔬🦠

Good chance you already listen to it, but if not @dancarlin.bsky.social Hardcore History is the best recommendation. Very long series each of them basically an audio book. Wrath of the Khans on the mongol empire would be a great start

We are looking for a postdoc with microbiology background for #superresolution #singlemolecule #ERC tracking project. Apply by 27.4.2025. 🦠🔬🧫
Pls share!

www.aalto.fi/en/open-posi...

Schematic of probability distribution of the latent period along with single-cell examples of bursts that increase in magnitude as the latent period increases. Full details in the paper.

New on #biorXiv: 'Inferring single-cell heterogeneity of bacteriophage life-history traits from population-scale dynamics'. A theory-experiment collaboration, led by @mariandm.bsky.social + Ran Tahan w/the Lindell group at Technion (and yes, I am excited).

a 🧵

www.biorxiv.org/contenat/10....

Genome duplication in a long-term multicellularity evolution experiment - Nature In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its...

1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social.

www.nature.com/articles/s41...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

A snowflake yeast cluster, with the MitoLoc mitochondrial fluorescent probe. The outer ~4-5 cell layers are aerobic and respiring, the interior is anaerobic.

Hi folks, I'm excited to share a whale of a tale (sorry, bad pun), where we engineer snowflake yeast to express sperm whale myoglobin, and explore how oxygen-binding proteins may have helped overcome anatomical limitations to early multicellularity. 🧪 #MEvoSky

journals.plos.org/plosbiology/...

Highly multiplexed spatial transcriptomics in bacteria Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...

This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫

If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)

PULSE SciLifeLab PULSE: Program for Future Leaders in Life Science SciLifeLab PULSE is a comprehensive postdoctoral program, that will train 48 future leaders in life sciences. PULSE focuses on innovative, ...

We are excited to announce that the call for the new SciLifeLab PULSE postdoctoral program is now open!

This unique program invites talented researchers to propose individually designed projects see : www.scilifelab.se/research/pul.... The deadline for applications is March 31, 2025.

בטיסה חזרה לישראל המעבר יכול לקחת יותר זמן, בעיקר אם טסים עם אלעל, כי צריך לעבור בדוכני צ'ק אין כדי לעבור את התשאול הבטחוני.

(כשכתבתי שזה מרגיש כמו קונקשן רגיל, זה בהנחה שעושים צ'ק אין אונליין)

עברתי את זה כבר כמה פעמים מאז תחילת המלחמה (משבדיה גם
בימים יפים בקושי היו טיסות ישירות).
אלא אם יש code share, מזמין ישירות מהחברות תעופה.
אם לא שולחים מזוודות, בטיסה מישראל, זה מרגיש בדיוק כמו קונקשן רגיל. עדיין ממליץ לקחת באפר גדול יותר בגלל שאין מי שיקח אחריות במקרה של איחור של הטיסה הראשונה.

We are seeking a motivated postdoc to join our lab!  Our research focuses on live-cell imaging/analysis to reveal how chromatin behaves in living cells and how its behavior contributes to cellular functions.
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Interested? Please DM me!