Autocrine RA production feeds back on DC function Fang et al. showed that GM-CSF–IL4, commonly used to differentiate bone marrow cells into DCs in vitro for use in vaccines, induced differentiation of DCs to express ALDH1A2 and produce retinoic acid...

Autocrine RA production feeds back on DC function
acir.org/weekly-diges...

Ludwig Princeton researchers led by Yibin Kang, Cao Fang and Mark Esposito report how a vitamin A derivative—retinoic acid—disrupts anti-cancer immune responses & the efficacy of a cancer vaccine + drug candidates to target both mechanisms for cancer immunotherapy.
bit.ly/4sItUdV

The image features a quote from Yibin Kang of Princeton University emphasizing the need for an integrated approach to understanding cancer, displayed alongside the PLOS Biology logo and a photograph of Yibin Kang.

Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow and adapt. @yibinkang.bsky.social introduces a new collection of articles that explore crosstalk between #cancer and its environment across temporal and spatial scales 🧪
plos.io/4moogJS

Anemia in Bone Metastasis Results When Cancer Cells Hijack Iron-Recycling Macrophages Researchers say findings offer potential therapeutic implications for both bone metastasis and cancer-associated anemia.

www.genengnews.com/topics/cance...

Tumors hijack macrophages for iron supply to promote bone metastasis and anemia Bone marrow is both a primary site for hematopoiesis and a fertile niche for metastasis. The mechanism of the common occurrence of anemia among patien…

I am proud to share our latest work on bone metastasis published today in Cell, by talented postdoc Yujiao Han. Tumor cell hijack iron macrophages and mimic erythroblasts to promote bone met and anemia. authors.elsevier.com/a/1liufL7PXuFvw

www.sciencedirect.com/science/arti...

The researcher who runs: A Princeton professor’s road from the lab to Ironman Lake Placid Yibin Kang has spent over two decades at Princeton University, currently serving as the Warner-Lambert/Parke-Davis Professor of Molecular Biology and a faculty adviser at Rockefeller College. Since jo...

inside.princeton.edu/community-ne...

So happy to complete Ironman Lake Placid and be medaled by Princeton alum, current OSU med student, IMLP champ and new course record holder Matthew Marquardt at the finish line after surviving 8000 ft of climb in the 112 mile bike, >1000 ft climb in the marathon and torrential rain.